A5101946532- RNA modifications and cancer
- RNA Interference and Gene Delivery
- Cholangiocarcinoma and Gallbladder Cancer Studies
- MicroRNA in disease regulation
- Ubiquitin and proteasome pathways
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- S100 Proteins and Annexins
- Dendrimers and Hyperbranched Polymers
- Eosinophilic Esophagitis
- Genomics, phytochemicals, and oxidative stress
- Protease and Inhibitor Mechanisms
- RNA Research and Splicing
- Invertebrate Immune Response Mechanisms
- Patient Satisfaction in Healthcare
- Galectins and Cancer Biology
- Bone health and treatments
- Bioactive Natural Diterpenoids Research
- Asthma and respiratory diseases
- Patient-Provider Communication in Healthcare
- Ferroptosis and cancer prognosis
- Phytochemistry and biological activities of Ficus species
- Cancer-related gene regulation
- Advanced Synthetic Organic Chemistry
- Curcumin's Biomedical Applications
Harbin Medical University
2023-2024
Fudan University
2005-2022
Zhongshan Hospital
2005-2022
Cangzhou Central Hospital
2014-2021
Second Military Medical University
2017-2021
Soochow University
2021
First Affiliated Hospital of Soochow University
2021
Tianjin Medical University General Hospital
2020
Hebei Medical University
2018-2019
Second Hospital of Hebei Medical University
2018-2019
The efficient delivery of biopharmaceutical drugs such as proteins and peptides into the cytosol target cells poses substantial challenges owing to their large size susceptibility degradation. Current protein vehicles have limitations need for modification, insufficient large-size or small peptides, loss function after delivery. Here, we adopted a rational approach design polymer with robust efficacy intracellular peptide is composed dendrimer scaffold, hydrophobic membrane-disruptive...
Pancreatic cancer (PC) has a dismal prognosis due to its insidious early symptoms and poor detection rate. Exosomes can be released by various cell types tend potential novel biomarker for PC detection. In this study, we explored the proteomic profiles of plasma exosomes collected from patients with at different stages other pancreatic diseases.Plasma samples were six groups patients, including stage I/II, III/IV, well-differentiated neuroendocrine tumor (P-NET), cystic lesions (PCLs),...
Malignant bone tumor accompanied by tumor-associated osteolysis remains a challenging task in clinical practice. Nanomedicines engineered with bone-targeting ligands, such as alendronate and pamidronate, are developed for targeted delivery of therapeutic agents to tumors. However, these targeting strategies usually show relatively poor selectivity toward the healthy skeletons osteolytic lesions because high binding affinity bisphosphonates all tissues. Here, we reported carboxyl-terminated...
Small proline-rich proteins (SPRRs), components of cornified cell envelope precursors, have recently been found to participate in airway diseases. However, their role allergic inflammatory conditions remains unknown. Here, we explored the expression SPRR3 house dust mite (HDM)-sensitized/challenged mice and attempted elucidate regulatory inflammation. was identified via bioinformatics analysis Gene Expression Omnibus (GEO) databases further confirmed be upregulated lungs asthmatic mice....
Annexin A9 (ANXA9), a member of annexin family, has been reported be associated with colorectal cancer (CRC) carcinogenesis. However, the clinical significance ANXA9 in CRC, particularly its correlation to invasion and metastasis remains ambiguous. The aim present study was investigate CRC understand molecular mechanism metastasis. Expression levels protein tissues were detected using immunohistochemistry (IHC), prognostic value investigated. ANXA9‑siRNA utilized effect HCT116 cells. IHC...
Biliary tract cancer (BTC) is a devastating malignancy that notoriously difficult to diagnose and associated with high mortality. Circular RNA (circRNA) class of endogenous non-coding which has been regarded as the key regulator tumor initiation progression, including BTC. nuclear receptor interacting protein 1 (circ_NRIP1), circular RNA, abnormally expressed in many human tumors exhibits diverse functions progression. However, its biological significance BTC not thoroughly investigated. In...
The regulation of Daphnoretin on specific tumours (e.g. cervical cancer, lung osteosarcoma) has been documented, which still remains unclear for colon cancer cells. Our study explored the suppression and its molecular mechanism proliferation, apoptosis, invasion migration human cell line HCT116. report showed activity HCT116 declined with time- dose- dependence after intervention, a rise in G0/G1 ratio decrease G2/M was observed. Daphnoretin-treated had migration, increased apoptosis rate,...
Breast cancer has a high prevalence in the general population and is often associated with bone metastasis. Specific therapeutic targets are missing for triple negative breast (TNBC), which presents some immunogenic characteristics. Betulinic acid (BA) been reported to have anti‑tumor properties, its modified derivative SH‑479 was demonstrated inhibit TNBC The present study aimed investigate effect of BA on microenvironment. MDA‑MB‑231 cell proliferation determined MTS method. cytotoxicity...
Background: Many studies have shown that solute carrier family 35 member F2 (SLC35F2) plays a key role in the biological processes of multiple cancers. However, there been no reports on SLC35F2 occurrence and development bladder cancer (BC). Methods: expression data clinical prognostic information from BC patients were obtained databases. was verified by quantitative real-time PCR (qRT-PCR). The influence knockdown proliferation, apoptosis, migration invasion 5637 T24 cell lines studied,...
To test the psychometric properties and applicability of European Organization for Research Treatment Cancer In-patient Satisfaction with Care Questionnaire 32 (EORTC IN-PATSAT32) Chinese patients gastrointestinal cancer.A total 106 inpatients cancer at Cangzhou Center Hospital were enrolled in this study. All treated from July 2013-March 2014. participants self-administered EORTC IN-PATSAT32 Quality Life - Core 30 QLQ-C30).The Cronbach's α coefficients >0.70 all scales IN-PATSAT32....
Abstract Background The role of the m 6 A-binding protein YTHDC2 in occurrence and development colorectal cancer (CRC) is unclear. We aimed to explore molecular mechanisms underlying this process clarify signaling pathway involved. Methods Firstly, relationship between CRC TCGA database was analyzed identify relevant pathways biological processes. Then, western blot used analyze expression HCT116 Caco2 cells. After knockdown or overexpression above cells, RT-PCR were p38MAPK, p-p38MAPK,...
Galectin-3 (Gal-3) as a multi-functional protein, is capable of specifically recognizing and binding to β-galactosides, which widely expressed in normal cells (such epithelial immune cells) tumor cells, involved variety life processes including cell growth, differentiation, adhesion, angiogenesis, progression metastasis [1][2][3][4][5][6][7][8][9] .galig was initially reported human galectin-3 internal gene, whose two open reading frames (ORF) are embedded gal-3 ORF encoding polypeptides,...
Objective To investigate the role of Annexin A9 (ANXA9) in proliferation human colon cancer cell line SW620 and underlying mechanism. Methods The expression ANXA9 lines HT29, SW620, SW480, LoVo SW1116 was detected by real-time quantitative polymerase chain reaction (Real-time PCR) Western blotting. with strongest transfected 40 nmol/L ANXA9-small interfering RNA (siRNA) to inhibit ANXA9. Cell counting kit-8 (CCK-8) assay flow cytometry (FCM) were correspondingly used examine effect...