A5062741923- Asthma and respiratory diseases
- Cancer-related molecular mechanisms research
- IL-33, ST2, and ILC Pathways
- Tuberous Sclerosis Complex Research
- MicroRNA in disease regulation
- Eosinophilic Disorders and Syndromes
- Respiratory and Cough-Related Research
- Eosinophilic Esophagitis
- RNA modifications and cancer
- Genomics, phytochemicals, and oxidative stress
- Air Quality and Health Impacts
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Circular RNAs in diseases
- Cancer-related gene regulation
- Peptidase Inhibition and Analysis
- Antifungal resistance and susceptibility
- Ga2O3 and related materials
- Protease and Inhibitor Mechanisms
- Prostate Cancer Treatment and Research
- Fungal Biology and Applications
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- RNA Research and Splicing
- Epigenetics and DNA Methylation
- Neonatal Respiratory Health Research
- Cancer Mechanisms and Therapy
The First Affiliated Hospital, Sun Yat-sen University
2020-2025
Zhongshan Hospital
2020-2025
Fudan University
2020-2025
Sun Yat-sen University
2020-2025
Shengli Oilfield Central Hospital
2016-2019
Background. Particulate matter (PM) exposure is related to mitochondria dysfunction and airway inflammation. Antioxidant drug edaravone (EDA) reported improve the occurrence development of oxidative stress-related diseases. At present, there no data on whether EDA can alleviate lung inflammation caused by PM. Methods. The anti-inflammatory effects were investigated in urban PM-induced human bronchial epithelial cells (HBECs) C57/BL6J mouse models. In vitro, its production intracellular...
Particulate matter (PM) has become the main risk factor for public health, being linked with an increased of respiratory diseases. However, potential mechanisms underlying PM-induced lung injury have not been well elucidated. In this study, we systematically integrated metabolomics, lipidomics, and transcriptomics data obtained from human bronchial epithelial cells (HBECs) exposed to PM reveal metabolic disorders in injury. We identified 170 differentially expressed metabolites (82...
Background: N6-methyladenosine (m6A) modification plays a crucial role in the regulation of diverse cellular processes influenced by environmental factors. Nevertheless, involvement m6A-modified long noncoding RNAs (lncRNAs) pathogenesis lung injury induced particulate matter (PM) remains largely unexplored. Methods: Here, we establish mouse model PM-induced injury. We utilized RNA immunoprecipitation sequencing (MeRIP-seq) to identify differentially expressed m6A peaks on non-coding...
Background: Bronchial provocation test (BPT) plays a crucial role in diagnosing airway hyper-responsiveness (AHR) among patients with asthma-like symptoms. Given that BPT may induce severe bronchospasm, baseline spirometric parameters are expected to help predict positive outcome, guiding the decision of referring patient BPT. Methods: Baseline spirometry and conducted on suspected asthmatics between July 2011 2013 at Department Pulmonary Medicine, Zhongshan Hospital, were retrospectively...
Small proline-rich proteins (SPRRs), components of cornified cell envelope precursors, have recently been found to participate in airway diseases. However, their role allergic inflammatory conditions remains unknown. Here, we explored the expression SPRR3 house dust mite (HDM)-sensitized/challenged mice and attempted elucidate regulatory inflammation. was identified via bioinformatics analysis Gene Expression Omnibus (GEO) databases further confirmed be upregulated lungs asthmatic mice....
The clinical features, treatment, and prognosis of allergic bronchopulmonary aspergillosis (ABPA) are not well-defined.We aimed to investigate the characteristics, therapy, ABPA aid its recognition.A total 232 patients with were analyzed retrospectively. characteristics in terms misdiagnosis, computed tomography classification, relationship asthma analyzed, risk factors for acute exacerbation based on follow-up data.Of patients, 132 had a history misdiagnosis. Compared misdiagnosed central...
Abstract Background Serine peptidase inhibitor, clade B, member 10 (SERPINB10) contributes to allergic inflammation in asthma. However, its role the T-helper type 2 (Th2) response of asthma is not known. The goal this study was unveil function SERPINB10 Th2 and mechanism by which affects viability cells. Methods cytokines serum levels house dust mite (HDM)-specific IgE bronchoalveolar lavage fluid were examined ELISA an HDM-induced model. number apoptosis Th1 cells mouse lungs measured flow...
Particulate matter (PM) exposure is identified as a critical risk factor for chronic airway diseases, but the biological mechanism of PM-induced lung damage was not fully elucidated. The m6A methylation, main member epigenetic modifications, has been found to play an important role in different pulmonary its regulatory effect on remains unknown. This study firstly used methylated RNA immunoprecipitation sequencing (MeRIP-seq) reveal methylome profiles tissues mice with acute PM exposure....
Abstract Background Lymphangioleiomyomatosis (LAM) is a rare disease which easily misdiagnosed. Vascular endothelial growth factor D (VEGF-D), as the most common biomarker, however, not so perfect for diagnosis and severity assessment of LAM. Materials methods The isobaric tags relative absolute quantitation (iTRAQ)-based method was used to identify cytoskeleton protein, moesin. 84 patients with LAM, 44 other cystic lung diseases (OCLDs), 37 healthy control subjects were recruited collecting...
Objective: MicroRNA-1271 (miR-1271) has a role in suppressing cell growth, cycle and promoting apoptosis many cancers. This research was to explore the great of miR-1271 ovarian cancer (OC). Patients Methods: RT-qPCR utilized evaluate mRNA levels its target gene. The proliferative invasive abilities were measured using Cell Counting Kit-8 transwell assays. overall survival rate OC patients assessed by Kaplan–Meier method. Results: downregulated tissues, downregulation predicted poor outcome...
MicroRNAs (miRNAs) have been reported in human diseases, which chronic obstructive pulmonary disease (COPD) is included. Herein, we assessed the role along with possible mechanisms of miR-150-5p cigarette smoke- (CS-) induced COPD. The plasma expression was lower patients COPD and acute exacerbation (AECOPD) related to diagnosis, severity, lung function. Consistently, exposure CS for 3 months or days reduced tissues mice, extract (CSE) inhibited bronchial epithelial cells (HBECs) a...
Abstract Background Severe asthma places a large burden on patients and society. The characteristics of with severe in the Chinese population remain unclear. Methods A retrospective review was conducted asthma. Demographic clinical data were collected. Patients grouped according to phenotypes terms exacerbations, body mass index (BMI) fixed airway obstruction (FAO) status, different groups compared. Comorbidities, factors that influence phenotypes, also analyzed study. Results total 228...
Abstract Background Lymphangioleiomyomatosis (LAM) is a rare disease which easily misdiagnosed. Vascular endothelial growth factor D (VEGF-D), as the most common biomarker, however, not so perfect for diagnosis and severity assessment of LAM. Materials methods The isobaric tags relative absolute quantitation (iTRAQ)-based method was used to identify cytoskeleton protein, moesin. 84 patients with LAM, 44 other cystic lung diseases (OCLD), 37 healthy control subjects were recruited collecting...
Abstract Background : Serine peptidase inhibitor, clade B, member 10 (SERPINB10) contributes to allergic inflammation in asthma. However, its role the T-helper type 1 (Th1) /Th2 response of asthma is not known. The goal this study was unveil function SERPINB10 Th2 and mechanism by which affects viability cells. Methods cytokines serum levels house dust mite (HDM)-specific IgE bronchoalveolar lavage fluid were examined ELISA an HDM-induced model. number apoptosis Th1 cells mouse lungs...
Abstract Background: Lymphangioleiomyomatosis (LAM) is a multisystem disease that mainly presents with cystic damage in the lungs. The purpose of this study was to quantify degree pulmonary CT and compare its correlation function tests (PFTs) serum levels vascular endothelial growth factor (VEGF-D). Subjects methods: 21 patients were included 36 scans PFTs analyzed. VEGF-D 17 their 24 studied. Cystic areas identified by software. volumetric percentage regions total lung volume calculated get...
Background: MicroRNAs (miRNAs) have been reported in human diseases, including chronic obstructive pulmonary disease (COPD). However, the role of miR-150-5p cigarette smoke (CS)-induced COPD remains unclear. Methods: Plasma was collected from non-smokers, smokers, and AECOPD patients. CSE-stimulated bronchial epithelial cells (HBECs) CS-exposed mice were constructed as vitro vivo models. Mimic or agomiR, small interfering RNA, overexpression plasmid inhibitors used to identify involved...