A5009608998- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Head and Neck Surgical Oncology
- Ear and Head Tumors
- Oral and Maxillofacial Pathology
- Acute Ischemic Stroke Management
- Ear Surgery and Otitis Media
- Head and Neck Anomalies
- Cleft Lip and Palate Research
- RNA Research and Splicing
- Salivary Gland Tumors Diagnosis and Treatment
- Peripheral Artery Disease Management
- RNA modifications and cancer
- Oral and gingival health research
- Cancer Immunotherapy and Biomarkers
- PI3K/AKT/mTOR signaling in cancer
- Cerebrovascular and Carotid Artery Diseases
- Renal and Vascular Pathologies
- Reconstructive Facial Surgery Techniques
- Reconstructive Surgery and Microvascular Techniques
- Neuroendocrine Tumor Research Advances
- Bioactive natural compounds
- Meningioma and schwannoma management
- Teratomas and Epidermoid Cysts
Beijing Friendship Hospital
2014-2023
Capital Medical University
2008-2023
GTx (United States)
2019
Shanghai Liangyou (China)
2019
Chinese PLA General Hospital
2007-2015
Beijing Anzhen Hospital
2011
Beijing Institute of Neurosurgery
2008
Siemens (China)
2008
CAE (Canada)
2007
Circular RNAs (circRNAs) exert critical functions in tumorigenesis and tumor development, but whether how circRNAs contribute to laryngeal squamous cell carcinoma (LSCC) is unclear. In this study, we explored the function mechanisms of circRNA_100290 LSCC. Tissue samples were obtained from 40 patients with The expression other targets was measured through quantitative reverse transcription-polymerase chain reaction western blot analysis. Cell proliferation, colony-forming ability, apoptosis...
Our previous studies have confirmed that α2δ1 has the potential to function as a cancer stem cell marker, and CACNA2D1 is coding gene of α2δ1. But it unclear how microRNAs regulate expression in laryngeal cells. We detected expressions protein, microRNA-107, 40 pairs tissues adjacent normal tissues. Laryngeal squamous carcinoma cells, TU212 TU686, were cultured transfected blank control group, agomiR negative agomiR-107 antagomiR or antagomiR-107 dual-luciferase reporter assay was employed...
Background: Wall shear stress (WSS) has been proven to play a critical role in the formation and development of atherosclerotic plaques. Measurement WSS vivo is significant for clinical assessment atherosclerosis. Purpose: To assess magnitude distribution local common carotid artery (CCA) using 3.0T magnetic resonance (MR). Material Methods: The eight healthy volunteers was studied cine phase-contrast MR sequence. A three-dimensional paraboloid model applied fit velocity profiles, values...
Aberrant expression of microRNAs (miRs) has been reported to be involved in nasopharyngeal carcinoma (NPC) carcinogenesis and development. The functions miR‑152 have previously studied several types cancer. However, the best our knowledge, no previous studies investigated effects on NPC. present study aimed explore expression, molecular mechanisms levels were detected NPC tissues cell lines using quantitative polymerase chain reaction (qPCR). Cell proliferation, migration invasion measured...
Cancer stem cells (CSCs) have the ability to dictate tumor initiation, recurrence, and metastasis. Here, we examined expression of aα2δ1+ in laryngeal cancer tissues further determined effect α2δ1 on migratory tumorigenicity cells. Immunofluorescence staining revealed that was positive 13 (13/16, 81.25%) cases squamous cell carcinoma (LSCC) tissues, 7 (7/16, 43.75%) paracancerous only 2 (2/16, 12.5%) normal tissues. Our quantitative RT-PCR assays showed α2δ1+ LSCC expressed significantly...
Conclusions: It is impossible to make a diagnosis of temporal giant cell granuloma (GCG) before operation because nonspecific clinical and imaging feature. Surgery the first-line choice treatment. Objective: To evaluate treatment GCG. Methods: Eight patients with GCG receiving in Chinese PLA General Hospital between 2001 2010 were recruited for study. These patients' features, histopathological findings, types surgery, results follow-up evaluations noted. Results: The group was made up four...
Background: Jieduhuayu No.3 (JDHY3) is a modified Chinese herbal formula beneficial for treating hypopharyngeal carcinoma (HC), but its pharmacological mechanism unknown. Objective: This study aimed to explore the of JDHY3 in inhibiting cell proliferation and promoting apoptosis HC vitro vivo. Methods: In this study, cells were treated with cisplatin different concentrations JDHY3. The rate was detected by flow cytometry. Western blotting used detect proteins related apoptosis. Afterward,...
Objective:To detect the expression of microRNA-107 （miR-107） and calcium channel protein gene CACNA2D1 in laryngeal cancer tissues, to investigate targeting relationship between miR-107 CACNA2D1, analyze effects on proliferation, invasion colony forming ability cells. Method:Laryngeal tissues normal adjacent tissue samples from 40 patients with were collected, qRT-PCR was used CACNA2D1; Western Blot assay α2δ1 above two tissues; dual-luciferase reporter regulatory effect after overexpression...
To verify the feasibility to demonstrate main blood vessels of whole fetal circulation applying spatio-temporal image correlation (STIC) combined with high definition flow (HDF). utilize STIC HDF display and rotate volume 3D images at any angle that needed. Satisfactory were obtained from 18 fetus but failed in 2 fetus, because mother or reasons. Among them, demonstration rates aortic arch, descending aorta, celiac trunk, superior mesenteric artery, umbilical vein all 90%, iliac artery 80%,...
To study clinical, imaging features and treatment outcomes of congenital cholesteatoma middle ear (CCME). This is a retrospective review 10 CCME cases selected from 952 treated between January 1995 December 2005 at the Department Otolaryngology-Head Neck Surgery, Chinese PLA General Hospital. The main outcome measures were site origin, clinical features, surgical findings, characteristics hearing results. mean age patients was 16 years(ranged to 24 years), with 6 being older than 18 years....
Mounting evidence has indicated that aberrantly expressed microRNAs (miRNAs) play key roles in tumorigenesis, including head and neck squamous cell carcinoma (HNSCC). Previous studies have shown miR‐335‐5p can serve as a tumor suppressor or an oncogene cancer. However, the clinical importance biological effects of HNSCC not been determined. Here, we investigated expression pattern, functional role, mechanisms HNSCC. We showed decreased samples from TCGA GEO databases. Consistently, detected...