A5101600224- NF-κB Signaling Pathways
- Natural product bioactivities and synthesis
- Cancer, Hypoxia, and Metabolism
- interferon and immune responses
- Bioactive natural compounds
- Bioactive Compounds and Antitumor Agents
- Ubiquitin and proteasome pathways
- Morinda citrifolia extract uses
- Immune Response and Inflammation
- Traditional Chinese Medicine Analysis
- Ginger and Zingiberaceae research
- Metabolism, Diabetes, and Cancer
- Cytokine Signaling Pathways and Interactions
- Pharmacological Effects of Natural Compounds
- PI3K/AKT/mTOR signaling in cancer
- Cell death mechanisms and regulation
- Natural Compounds in Disease Treatment
- Phytochemistry and biological activities of Ficus species
- Peroxisome Proliferator-Activated Receptors
- Liver physiology and pathology
- Bone Metabolism and Diseases
- Flavonoids in Medical Research
- Cancer-related molecular mechanisms research
- Bioactive Natural Diterpenoids Research
- Medicinal plant effects and applications
Yanbian University
2011-2024
Shanghai Jiao Tong University
2017
Guangzhou Medical University
2014
Korea Research Institute of Bioscience and Biotechnology
2010
Artemisinin, isolated from the Chinese plant Artemisia annua, has been used for many years to treat different forms of malarial parasites. In this study, we explored anti-inflammatory activity artemisinin and underlying mechanism action. We demonstrated that effects in TPA-induced skin inflammation mice. Then significantly inhibited expression NF-κB reporter gene induced by TNF-α a dose-dependent manner. Artemisinin also phosphorylation degradation IκBα, p65 nuclear translocation. an impact...
A new turn-on fluorescent probe for fast detection of cysteine in physiological conditions, based on a response-assisted electrostatic attraction strategy, is reported. The practical utility the protein labeling and subcellular imaging also demonstrated.
The NF-κB transcription factors control many physiological processes, including inflammation, immunity, and apoptosis. Its activity contributes to the development of various cell malignancies. NF-κB-inducing kinase (NIK) plays a pivotal role in activation. However, molecular mechanism stabilize activate NIK remains elusive, although it is known that cIAP1/2 (cellular inhibitor apoptosis 1 2) ubiquitinate for degradation. Here, we report novel NF-κB-related zinc finger protein 91 (ZFP91)...
Nuclear factor-κB (NF-κB) and the signaling pathways that regulate its activity have become a focal point for intense drug discovery development efforts. NF-κB regulates transcription of large number genes, particularly those involved in immune, inflammatory, antiapoptotic responses. In our search inhibitors from natural resources, we identified cardamomin, 2′,4′-dihydroxy-6′-methoxychalcone, as an inhibitor activation <i>Alpinia conchigera</i> Griff (Zingiberaceae). present study,...
Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) is a complex that regulates several hundreds genes, including those involved in immunity and inflammation, survival, proliferation, the negative feedback NF-κB signaling. Chelidonine, major bioactive, isoquinoline alkaloid ingredient Chelidonium majus, exhibits antiinflammatory pharmacological properties. However, its molecular mechanisms remain unclear. In this work, we explored effect chelidonine on TNF-induced...
Background Cryptopleurine, a phenanthroquinolizidine alkaloid, was known to exhibit anticancer activity; however, the underlying mechanism is poorly understood. Because nuclear factor-κB (NF-κB) transcription factors control many physiological processes including inflammation, immunity, and development progression of cancer, we investigated effects cryptopleurine on tumor necrosis factor alpha (TNF-α)-induced NF-κB activation pathway expression NF-κB-regulated gene products associated with...
The motion of liquid metal has potential applications ranging from micro-pumps and self-fueled motors to rapid cooling drug delivery. In this study, we systematically investigate the effects radius LMDs (liquid droplets), concentration electrolyte solution applied electric field on movement behavior experimentally. research also explains experimental phenomenon with an innovative modeling analysis, which combines pertinent forces (i.e., driving force induced by gradient surface tension,...
The NF-κB signaling pathway plays a pivotal role in regulating the immune response and inflammation. However, it has been shown that also major oncogenesis. Therefore, inhibitors have considered as potential drugs against cancer. Herein, we searched for from natural sources identified mollugin roots of Rubia cordifolia L. an inhibitor activation. We found significantly inhibited expression reporter gene induced by tumor necrosis factor (TNF)-α dose-dependent manner. Moreover, TNF-α-induced...
Cucurbitacin B, a natural triterpenoid is well-known for its strong anticancer activity, and recent studies showed that the compound inhibits JAK/STAT3 pathway. In this study, we demonstrate first time cucurbitacin B also potent inhibitor of NF-κB activation. Our results inhibited TNF-α-induced expression reporter gene target genes in dose-dependent manner, however, it did not prevent either stimuli-induced degradation IκBα or nuclear translocation DNA-binding activity NF-κB. On other hand,...
The nuclear factor-κB (NF-κB) transcription factors control many physiological processes including inflammation, apoptosis, and angiogenesis. In our search for NF-κB inhibitors from natural resources, we identified 4′,6-dihydroxy-4-methoxyisoaurone (ISOA) as an inhibitor of activation the seeds Trichosanthes kirilowii. However, mechanism by which ISOA inhibits is not fully understood. present study, demonstrated effect on in TNF-α-stimulated HeLa cells. This compound suppressed through...