A5044226480- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Traditional Chinese Medicine Analysis
- Pharmacological Effects of Natural Compounds
- Berberine and alkaloids research
- Chromatography in Natural Products
- Bioactive natural compounds
- Metabolomics and Mass Spectrometry Studies
- Computational Drug Discovery Methods
- Phytochemistry and Bioactive Compounds
- Essential Oils and Antimicrobial Activity
- Immune Response and Inflammation
- Saffron Plant Research Studies
- Fungal Biology and Applications
- Influenza Virus Research Studies
- Plant-based Medicinal Research
- Microbial Natural Products and Biosynthesis
- Pediatric health and respiratory diseases
- Flavonoids in Medical Research
- Ginseng Biological Effects and Applications
- Ginger and Zingiberaceae research
- Bioactive Compounds and Antitumor Agents
- Inflammatory mediators and NSAID effects
- Synthesis and biological activity
- Ziziphus Jujuba Studies and Applications
Guangxi Normal University
2022-2025
University of Macau
2025
Beihai People's Hospital
2024
Guangzhou Institutes of Biomedicine and Health
2024
Chinese Academy of Sciences
2024
First Affiliated Hospital of Jinan University
2020-2022
Jinan University
2017-2021
State Council of the People's Republic of China
2021
Abstract A target and nontarget strategy based on in‐house chemical components library was developed for rapid comprehensive analysis of complicated from traditional Chinese medicine preparation Shuang‐Huang‐Lian oral liquid. The sample analyzed by ultra‐performance liquid chromatography–quadrupole time‐of‐flight mass spectrometry using generic acquisition parameters. Automated detection data filtering were performed the UNIFI™ software detected peaks evaluated against an library. As a...
ABSTRACT Rationale Protopine, an active alkaloid in Papaver somniferum L., was abundant a well‐known anticough traditional Chinese medicine preparation—Zhi‐Ke‐Bao tablets. Till now, the metabolism feature and mechanism of protopine have not been fully elucidated, restricting its further development. Methods The metabolites rats were profiled by using ultra‐high performance liquid chromatography coupled with time‐of‐flight mass spectrometry, targets predicted network pharmacology. Results In...
Rationale Traditional Chinese medicines (TCMs) attract worldwide attention because of their effects in clinical application recorded China historical ancient codes and records, such as ‘Treatise on Febrile Diseases’. With the developments drug analysis research, evaluating vivo substances TCMs has become great importance. Scutellariae Radix (SR, named huang‐qing China) , root Scutellaria baicalensis Georgi, shown favorable safety treatment infection diseases; however, its compounds are...
Food additives are widely used in our daily life, and the side-effects caused by them have gained extensive attention around world.
Matrine (MT) is a major bioactive compound extracted from Sophorae tonkinensis. However, the clinical application of MT relatively restricted due to its potentially toxic effects, especially hepatotoxicity. Although MT-induced liver injury has been reported, little known about underlying molecular mechanisms. In this study, transcriptomics and metabolomics were applied investigate hepatotoxicity in mice. The results indicated that occurred when administration (30 or 60 mg/kg, i.g) lasted for...
Xian-Ling-Gu-Bao capsule (XLGB), a well-known traditional Chinese medicine prescription, has been used for the prevention and treatment of osteoporosis. The safety efficacy XLGB have confirmed based on principle evidence-based medicine. is usually administered orally, after which its multiple components are brought into contact with intestinal microflora in alimentary tract biotransformed. However, investigations comprehensive metabolic profile absent. In this study, 12 representative...
Abstract Periplocae Cortex, named Xiang‐Jia‐Pi in China, has been widely used to treat autoimmune diseases, especially rheumatoid arthritis. However, the vivo substances of Cortex remain unknown yet. In this study, an ultra‐performance liquid chromatography coupled with quadrupole time‐of‐flight mass spectrometry was for profiling chemical components and related metabolites Cortex. A total 98 constituents were identified or tentatively characterized Cortex: 42 C21 steroidal glycosides, 10...
The prototypes and metabolites formed from the use of traditional Chinese medicines (TCM) are typically cause both side side-effects therapeutic results. Therefore, characterization in vivo substances determination functional changes great importance for clinical applications. Secoisolariciresinol-diglycoside (SDG), one major compound flaxseeds, was used as a potential drug to treat tumors clinic; however, metabolism information SDG were limited, which limited its application. In this study,...
Salvianolic acid B (Sal B), the Q-marker in Salvia miltiorrhiza, was proved to present an obvious anti-diabetes effect when treated as a food intake. Until now, metabolism feature, tissue distribution and mechanism of Sal have not been fully elucidated.The metabolites rats were profiled using ultrahigh-performance liquid chromatography coupled with time-of-flight mass spectrometry. The potential predicted by network pharmacology.A total 31 characterized after ingestion at dosage 40 mg/kg,...
Screening potential functional substances based on active compounds is still a challenge faced by researchers since hundreds and thousands of possible exist in natural products (food, herb, etc.). In this study, an integrated strategy combination structural similarity evaluation, ADME (absorption, distribution, metabolism, excretion) prediction, network pharmacology experimental validation (SANE strategy) was proposed applied to explore anti-adipogenesis substances. This divided into four...
In this work, four new cyclodepsipeptides, fusarihexins C–E (1–3) and enniatin Q (4), cyclopentane derivatives, fusarilins A–D (5–8), together with eight known compounds (9–16), were isolated from cultures of the endophytic fungus Fusarium sp. The structures elucidated by analysis HRMS NMR spectroscopic data. absolute configurations determined using Marfey's method, a modified Mosher's single-crystal X-ray diffraction analysis, ECD analysis. antitumor activities in vitro evaluated....
Somatic cell reprogramming generates induced pluripotent stem cells (iPSCs), which serve as a crucial source of seed for personalized disease modeling and treatment in regenerative medicine. However, the process often causes substantial lineage manipulations, thereby increasing cellular heterogeneity. As consequence, harvesting monoclonal iPSCs is labor-intensive leads to decreased reproducibility. Here, we report first in-house developed robotic platform that uses pin-tip-based...
Rationale Eucommia cortex is the core herb in traditional Chinese medicine preparations for treatment of osteoporosis. Pinoresinol diglucoside (PDG), quality control marker and key pharmacodynamic component cortex, has attracted global attention because its definite effects on However, vivo metabolic characteristics PDG anti‐osteoporotic mechanism are still unclear, restricting development application. Methods Ultra‐high‐performance liquid chromatography coupled with quadrupole...
Characterizing the functional mechanism of quality control marker (Q-marker) was great importance in revealing primary pharmacological herbs or other complex system, and drug-related metabolites always contribute to functions. Cortex Phellodendri used as a core herb treatment diabetes mellitus (DM). As Q-marker Phellodendri, role phellodendrine DM still unclear. Thus, characterization phellodendrine-related vivo subsequent induced exerted elucidating anti-DM Phellodendri.An...
Tetrandrine, the Q-marker in Stephaniae Tetrandrae Radix, was proven to present an obvious antitumor effect. Until now, metabolism and mechanism of tetrandrine have not been fully elucidated.The metabolites rats were profiled using ultra-high-performance liquid chromatography coupled with time-of-flight mass spectrometry. The potential vivo predicted network pharmacology.A total 30 characterized after ingestion (10 mg/kg), including 0 plasma, 7 urine, 11 feces, 9 liver, 8 spleen, 4 lung, 5...