A5019559496- Saffron Plant Research Studies
- Phytochemical and Pharmacological Studies
- Bee Products Chemical Analysis
- Phytochemicals and Antioxidant Activities
- Bladder and Urothelial Cancer Treatments
- Medicinal Plants and Bioactive Compounds
- Immune cells in cancer
- Cancer, Hypoxia, and Metabolism
- Cancer, Stress, Anesthesia, and Immune Response
- Antioxidant Activity and Oxidative Stress
- Cancer Immunotherapy and Biomarkers
- Nanoplatforms for cancer theranostics
- Medicinal plant effects and applications
- Extracellular vesicles in disease
- Traditional Chinese Medicine Analysis
- Cancer, Lipids, and Metabolism
- Flavonoids in Medical Research
- Ferroptosis and cancer prognosis
- Ultrasound and Hyperthermia Applications
- Advanced Causal Inference Techniques
- Soil and Environmental Studies
- Cancer survivorship and care
- Pharmacology and Obesity Treatment
- Tryptophan and brain disorders
- Metabolism, Diabetes, and Cancer
Zhongshan Hospital
2023-2024
Fudan University
2020-2024
Shanghai Institute of Organic Chemistry
2024
Sun Yat-sen University
2023-2024
The First Affiliated Hospital, Sun Yat-sen University
2023-2024
Sichuan University
2023
State Key Laboratory of Biotherapy
2023
China Pharmaceutical University
2005-2022
Huashan Hospital
2020-2021
Nanjing University of Aeronautics and Astronautics
2011-2018
Surgical resection remains the prefer option for bladder cancer treatment. However, effectiveness of surgery is usually limited high recurrence rate and poor prognosis. Consequently, intravesical chemotherapy synergize with immunotherapy in situ an attractive way to improve therapeutic effect. Herein, a combined strategy based on thermo-sensitive PLEL hydrogel drug delivery system was developed. GEM loaded instilled kill tumor cells directly, then incorporated CpG injected into both groins...
Background/Aim: Crocetin is a readily bioavailable and bioactive compound extracted from Saffron. Previous studies indicated its various biomedical properties including antioxidant anti-coagulation potencies. However, effect on inflammation, notably within the cardiovascular system, has not been investigated yet. In present study, we utilized human umbilical vein endothelial cell (HUVEC) to elucidate of vascular inflammation. Methods: Cell viability toxicity were evaluated by MTT Lactate...
Combination immunotherapy is a promising strategy to remove the inhibitory effect of tumor microenvironment on immune effector cells, improving efficacy checkpoint inhibitor treatment in bladder cancer. However, it challenging deliver multiple drugs tissue effectively and simultaneously ensure optimal therapeutic effects. Macrophage-derived exosome-mimetic nanovesicles (EMVs) were designed validated as nanoplatform for coloading delivery CD73 (AB680) monoclonal antibody programmed cell death...
Activation of the stimulator interferon genes (STING) pathway to achieve antitumor response is an attractive approach for cancer immunotherapy. In this study, we report identification BSP16 (LF250) as a potent, orally available STING agonist. strongly activates signaling in human and mouse cells binds homodimer. A 2.4 Å cocrystal structure revealed that could induce "closed" conformation STING. vivo studies well tolerated, has excellent pharmacokinetic profile oral drug, induces tumor...
Background/Aim: Ulcerative colitis (UC) is characterized by oxidative and nitrosative stress, leukocyte infiltration upregulation of proinflammatory cytokines. In this study, we aim to investigate the effects crocetin its protective mechanism on 2,4,6- trinitrobenzene sulfonic acid (TNBS)-induced in mice model. Materials Methods: Intestinal lesions (judged macroscopic histological score) were associated with neutrophil (measured as increase myeloperoxidase (MPO) activity mucosa), high levels...
Oxidation of low-density lipoprotein plays a crucial role in the pathogenesis atherosclerosis, raising possibility using antioxidants as an inhibitor atherosclerosis. However, studies with have led to contradictory results. In present study, we investigated effect crocetin, carotenoid potent antioxidant activity, on experimental atherosclerosis rabbits. After 8 weeks feeding high lipid diet, rabbits developed severe atherosclerotic lesions thoracic aortas (P < 0.01), together significant...
The amelioration of insulin resistance by treatment with crocetin is closely related to the hypolipidaemic effect. present study designed clarify insulin-sensitizing mechanism elucidating regulation lipid metabolism crocetin.
Multiple organ failure is a common outcome of hemorrhagic shock followed by resuscitation, and the kidney one prime target organs involved. The main objective study was to evaluate whether crocetin, natural product from Gardenia jasminoides Ellis, has beneficial effects on renal dysfunction caused resuscitation in rats. Anesthetized rats were bled reduce mean arterial blood pressure 35 (SD, 5) mmHg for 60 min then resuscitated with their withdrawn shed normal saline. Crocetin administered...
Abstract: Crocin, extracted and purified from Gardenia jasminoids Ellis in our laboratory, has been reported to have antioxidative, hypolipidaemic anti‐atherosclerorotic effects. However, the underlying molecular mechanisms by which crocin acts as a cytoprotective agent remain be elucidated. In present study, we examined of crocin, digentiobiosyl ester crocetin, on bovine aortic endothelial cell apoptosis induced hydrogen peroxide (H 2 O ). The cells were obtained thoracic aorta newborn...
Background and purpose: A number of studies have implicated adipocyte‐derived factors in the development insulin resistance. Intracellular redox status has been reported to play a significant role modulation action. This study was designed investigate potential crocetin, potent antioxidant, protect adipocytes against induction insensitivity disordered expression tumor necrosis factor (TNF)‐α adiponectin vitro . Experimental approach: We used palmitate induce resistance freshly isolated rat...