A5078944760- Renal cell carcinoma treatment
- Bladder and Urothelial Cancer Treatments
- Cervical Cancer and HPV Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Immunotherapy and Biomarkers
- Genital Health and Disease
- Spinal Fractures and Fixation Techniques
- Nanoplatforms for cancer theranostics
- Cancer Genomics and Diagnostics
- Renal and related cancers
- Reproductive tract infections research
- Traumatic Brain Injury and Neurovascular Disturbances
- Immune cells in cancer
- Scoliosis diagnosis and treatment
- MicroRNA in disease regulation
- Photodynamic Therapy Research Studies
- Pancreatic and Hepatic Oncology Research
- Meningioma and schwannoma management
- Neurosurgical Procedures and Complications
- Gastric Cancer Management and Outcomes
- Spinal Dysraphism and Malformations
- Spine and Intervertebral Disc Pathology
- Ultrasound and Hyperthermia Applications
- Inflammatory Biomarkers in Disease Prognosis
- Venous Thromboembolism Diagnosis and Management
Ochsner Health System
2024-2025
Wenzhou Medical University
2024
Ochsner Medical Center
2024
Wuhan Polytechnic University
2023
State Key Laboratory of Biotherapy
2021-2023
Sichuan University
2021-2023
Hunan University of Traditional Chinese Medicine
2023
The People's Hospital of Guangxi Zhuang Autonomous Region
2022-2023
Ningbo No. 2 Hospital
2010-2022
Guangxi Medical University
2022
Surgical resection remains the prefer option for bladder cancer treatment. However, effectiveness of surgery is usually limited high recurrence rate and poor prognosis. Consequently, intravesical chemotherapy synergize with immunotherapy in situ an attractive way to improve therapeutic effect. Herein, a combined strategy based on thermo-sensitive PLEL hydrogel drug delivery system was developed. GEM loaded instilled kill tumor cells directly, then incorporated CpG injected into both groins...
ABSTRACT Incorporating molecular testing for human papillomavirus (HPV) into the screening of cervical specimens can improve risk stratification and, in turn, patient management. Infection with a high-risk (HR) HPV genotype is associated greater persistent infection, viral integration, and progression neoplasia. Current guidelines consider 16 or 18 clinically actionable referral to colposcopy; however, 12 Other HR genotypes have been cancer risk, suggesting benefit extended genotyping. In...
The technique of sub-pial resection, first described in the early 1900s, was later refined by Penfield and Jasper for removal supratentorial epileptic cortex. This has not been widely adopted intrinsic tumor which most used involves piecemeal aspiration tumor. "staying within tumor" results persistent bleeding, with obscuration tumor/brain interface, potentially yielding less than satisfactory results. In our experience, is useful resections We report use resection present illustrative...
Objective: Nivolumab improves overall survival (OS) and is associated with fewer adverse events than sorafenib for the treatment of advanced hepatocellular carcinoma (aHCC). However, cost-effectiveness nivolumab compared aHCC remains unclear. This study evaluated in aHCC. Materials methods: A partitioned model that included three mutually exclusive health states was used to evaluate treating The clinical characteristics outcomes patients were obtained from CheckMate 459. We performed...
Cerebral ischemia, which is a leading cause of disability and mortality worldwide, sets off chain molecular cellular pathologies that are associated with some central nervous system (CNS) disorders, mainly including ischemic stroke, Alzheimer's disease (AD), Parkinson's (PD), epilepsy other CNS diseases. In recent times, despite significant advancements in the treatment pathological processes underlying various neurological illnesses, effective therapeutic approaches specifically targeted at...
Objective To investigate the effectiveness and safety of high-intensity focused ultrasound (HIFU) ablation for patients with colorectal liver metastases (CRLMs) who were unsuitable hepatectomy.Methods This is a multicenter retrospective study. 238 CRLM underwent ultrasound-guided HIFU (USgHIFU) in three medical centers from October 2014 to December 2020. Patients had complete cancer resection, but exhibited extra-hepatic metastasis excluded this procedure was performed, contrast-enhanced MR...
The detection and analysis of methylene tetrahydrofolate reductase (MTHFR) C677T single nucleotide polymorphism (SNP) from blood samples is time-consuming costly. We aimed to establish a method detect these SNPs by direct whole PCR without DNA extraction.Probes modified different fluorescent groups on the same sequence were designed. Various MTHFR genotypes experiments used verify similarity obtained sequencing results. SNP sites adjacent whether can accurately distinguish sites.The ROX...
Surgical treatment is mainly used for atlantoaxial tuberculosis with neurological damage. However, the anatomic structure around joint complex, and position of vertebral body deep, which increases difficulty operation it challenging surgeon to develop surgical strategy. The purpose this study was evaluate clinical outcomes one-stage combined anterior posterior approach impairment.From January 2005 2015, 12 patients suffering from impairment were surgically treated by approach. Preoperative...
Pembrolizumab and cemiplimab have been approved as treatment for advanced non-small-cell lung cancer (NSCLC) with high programmed death ligand-1 (PD-L1) expression. This study aimed to evaluate the cost-effectiveness of pembrolizumab compared that in NSCLC PD-L1 expression from a societal perspective United States. Cost-effectiveness analysis integration network meta-analysis framework was performed using data EMPOWER-Lung 1, KEYNOTE 024, 042 phase 3 randomized clinical trials. A including...
Object The treatment of craniocervical instability in children is often challenging due to their small spine bones, complex anatomy, and unique syndromes. authors discuss surgical experience with 33 cases the 31 (≤17 years age) using smaller nontraditional titanium screws plates, as well intraoperative CT. Methods All fusion procedures were performed fluoroscopic imaging electrophysiological monitoring. Nontraditional hardware included screw sizes (2.4 2.7 mm) from orthopedic hand/foot set...
BACKGROUND:This population study aimed to identify suitable candidates for cytoreductive nephrectomy in patients with metastatic sarcomatoid renal cell carcinoma (RCC) from the US Surveillance, Epidemiology, and End Results (SEER) database. MATERIAL AND METHODS:Demographic clinical data 1,229 RCC were retrieved SEER Patients divided into group (n=937) no surgery (n=292). Multivariate Cox regression analysis identified factors associated overall survival (OS) propensity score matching that...
Sarcomatoid renal cell carcinoma is a rare variant of associated with poor clinical outcomes. Currently no reliable evidence indicates whether partial nephrectomy can be an effective treatment for patients T1N0M0 sarcomatoid carcinoma. The present study was conducted to compare the overall and cancer-specific survival radical such cases.Data were retrieved from Surveillance, Epidemiology, End Results database. Factors independently or identified by Cox regression analysis. propensity-score...
Abstract Objectives Evidence suggests that co-infection with sexually transmitted infection (STI) pathogens may support HPV persistence and cervical disease progression neoplasia. We examined the prevalence of other common STI in liquid-based cytology (LBC) specimens, their association by cytology. Methods In this retrospective, cross-sectional study, 149 randomly selected remnant collected LBC as part routine cancer screening a large urban academic healthcare system, were tested on Alinity...
Abstract Background Certain high-risk human papillomavirus (HR HPV) genotypes may carry greater risk of progression to high-grade cervical cancer, and extended HR HPV genotyping help refine assessment. Objectives To examine the performance Alinity m assay in comparison cobas 4800 (cobas 4800) association between cytology results, age, genotyping. Study design This was a cross-sectional cohort study 149 de-identified remnant specimens collected ThinPrep as part routine cancer screening...