A5110244411- Particle Accelerators and Free-Electron Lasers
- Particle accelerators and beam dynamics
- Gyrotron and Vacuum Electronics Research
- Nanoplatforms for cancer theranostics
- Advanced X-ray Imaging Techniques
- Luminescence and Fluorescent Materials
- X-ray Spectroscopy and Fluorescence Analysis
- Photodynamic Therapy Research Studies
- Superconducting Materials and Applications
- Enzyme Structure and Function
- Advanced biosensing and bioanalysis techniques
- Scientific Research and Discoveries
- Stellar, planetary, and galactic studies
- ATP Synthase and ATPases Research
- Mitochondrial Function and Pathology
- Parallel Computing and Optimization Techniques
- Terahertz technology and applications
Wenzhou Medical University
2023-2024
Brookhaven National Laboratory
2004-2016
RIKEN BNL Research Center
2004-2007
Abstract Bacterial infections are closely correlated with the genesis and progression of cancer, elimination cancer‐related bacteria may improve efficacy cancer treatment. However, combinatorial therapy that utilizes two or more chemodrugs will increase potential adverse effects. Image‐guided photodynamic is a highly precise to treat tumor microbial infections. Herein, four donor–acceptor–π‐bridge–acceptor (D–A–π–A) featured near‐infrared (NIR) aggregation‐induced emission luminogens...
Rational design of organelle targeted therapeutic platform in where the drug can be to destroy tumor cells as much possible, is one effective ways improve outcomes and minimize cytotoxicity normal cells. Here, photosensitizer TSPy-B with aggregation-induced emission (AIE) feature, biotin receptor mitochondria dual-targeted capability, high reactive oxygen species (ROS) generation efficiency was designed for fluorescence imaging guided photodynamic therapy (PDT) by linking group D-π-A type...
The National Synchrotron Light Source II (NSLS-II) is a state of the art 3 GeV third generation light source at Brookhaven Laboratory. During spring/ summer 2014, storage ring was commissioned up to 50 mA without insertion devices. In fall we began commissioning project beamlines, which included seven devices on six ID ports. Beamlines IXS, HXN, CSX-1, CSX-2, CHX, SRX, and XPD-1 consist elliptically polarized undulator (EPU), damping wigglers (DW) in-vacuum undulators (IVU) covering from VUV...
We present the conceptual design of NSLS-II injection system [1, 2]. The consists a low-energy linac, booster and transport lines. review two different configurations; located in storage ring tunnel housed separate building. briefly discuss main parameters layout components.
To address the growing needs of NSLS user community we are aggressively pursuing R&D towards a facility upgrade. The present goals 3 GeV ultra-low emittance storage ring, tailored to 5-20 keV photon energy range, that will triple ID capacity, and provide three orders magnitude increase in brightness over brightest beamlines. achieve these propose 24 period TBA lattice, with extensive use super-conducting small gap undulators. This paper reviews our preliminary design key accelerator physics issues.
A new high-brightness synchrotron light source (NSLS-II) is under design at BNL. The 3-GeV NSLS-II storage ring has a double-bend achromatic lattice with damping wigglers installed in zero-dispersion straights to reduce the emittance below 1 nm. In this paper, we present an overview of impact collective effects upon performance ring. Subjects discussed include instability thresholds, Touschek lifetime and intra-beam scattering.
The linac at the NSLS Source Development Lab (SDL) provides a high brightness electron beam for DUV-FEL project with subpicosecond bunch length and several hundred Amperes peak current by means of photoinjector magnetic compressor. Previous diagnostics longitudinal dynamics relied on rf zero-phasing method measurements CTR spectra. In order to have fast nonintercepting diagnostic available, electro-optic measurement technique has been implemented its major component, synchronized 100 fs...
Quiet start scheme is broadly utilized in self amplified spontaneous radiation (SASE) FEL simulations, which proven to be correct and efficient. Nevertheless, due the energy modulation dispersion section, high gain harmonic generation (HGHG) simulation will not improved by traditional quiet method. A new approach presented largely decrease number of macro-particles per slice that can implemented both time-independent time-dependent simulation, accordingly expedites order cascade makes...
The NSLS-II storage ring [1] will operate in the top-off mode order to achieve stability required for full utilization of ultra-small emittance. injection process is expected have near 100% efficiency reduce radiation levels. This task complicated by strong nonlinearities produced sextupoles and insertion devices. simulations described below are performed establish requirements system including emittance injected beam its stability.