A5026172279- Particle Accelerators and Free-Electron Lasers
- Particle accelerators and beam dynamics
- Superconducting Materials and Applications
- Gyrotron and Vacuum Electronics Research
- Respiratory Support and Mechanisms
- Magnetic confinement fusion research
- Trauma and Emergency Care Studies
- Cardiac Arrest and Resuscitation
- Sepsis Diagnosis and Treatment
- Thermal Regulation in Medicine
- Particle Detector Development and Performance
- Abdominal Surgery and Complications
- COVID-19 Clinical Research Studies
- COVID-19 and healthcare impacts
- Advanced X-ray Imaging Techniques
- Distributed and Parallel Computing Systems
- Intensive Care Unit Cognitive Disorders
- Appendicitis Diagnosis and Management
- solar cell performance optimization
- Electromagnetic Simulation and Numerical Methods
- Silicon Carbide Semiconductor Technologies
- SARS-CoV-2 and COVID-19 Research
- COVID-19 diagnosis using AI
- Anesthesia and Sedative Agents
- Pneumothorax, Barotrauma, Emphysema
Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda
2015-2024
Brookhaven National Laboratory
2015-2024
ETH Zurich
2020-2021
Cockcroft Institute
2007-2010
University of Liverpool
2007-2010
Universität Ulm
2006-2008
University Hospital Ulm
2008
Ospedale San Paolo
2008
German Academic Exchange Service
2008
Eli Lilly (Italy)
2008
The COVID-19 pandemic drastically strained the health systems worldwide, obligating reassessment of how healthcare is delivered. In Lombardia, Italy, a Regional Emergency Committee (REC) was established and regional system reorganized, with only three hospitals designated as hubs for trauma care. aim this study to evaluate effects reorganization care, comparing distribution patients before during outbreak describe changes in epidemiology severe among two periods.A cohort conducted using...
Objective: Early goal-directed therapy aims at balancing tissue oxygen delivery and demand. Hyperoxia (i.e., pure breathing) has not been studied in this context, since sepsis increases radical production, which is believed to be directly related the tension. On other hand, breathing improved survival various shock models. Therefore, we hypothesized that hyperoxia may beneficial during early septic shock. Design: Laboratory animal experiments. Setting: Animal research laboratory university...
A versatile and Lipinski-compliant DNA-encoded library (DEL), comprising 366 600 glutamic acid derivatives coupled to oligonucleotides serving as amplifiable identification barcodes is designed, constructed, characterized. The GB-DEL library, constructed in single-stranded DNA format, allows de novo of specific binders against several pharmaceutically relevant proteins. Moreover, hybridization the DEL with a set known protein ligands low medium affinity complementary strand results...
Reverse Transcription-Polymerase Chain Reaction (RT-PCR) for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-COV-2) diagnosis currently requires quite a long time span. A quicker and more efficient diagnostic tool in emergency departments could improve management during this global crisis. Our main goal was assessing the accuracy of artificial intelligence predicting results RT-PCR SARS-COV-2, using basic information at hand all departments.This is retrospective study carried out...
DNA-encoded chemical libraries are typically screened against purified protein targets. Recently, cell-based selections with encoded have been described, commonly revealing suboptimal performance due to insufficient recovery of binding molecules. We used carbonic anhydrase IX (CAIX)-expressing tumor cells as a model system optimize selection procedures code-specific quantitative polymerase chain reaction (qPCR) readout. Salt concentration and performing PCR on cell suspension had the biggest...
Changing trunk inclination affects lung function in patients with ARDS. However, its impacts on PEEP titration remain unknown. The primary aim of this study was to assess, mechanically ventilated COVID-19 ARDS, the effects titration. secondary compare respiratory mechanics and gas exchange semi-recumbent (40° head-of-the-bed) supine-flat (0°) positions following titration.Twelve were positioned both at 40° 0° (randomized order). associated best compromise between overdistension collapse...
Background: Aortic occlusion causes ischemia/reperfusion injury, kidney and spinal cord being the most vulnerable organs. Erythropoietin improved injury in rodents, which, however, better tolerate than larger species. Therefore, we investigated whether erythropoietin attenuates porcine aortic injury. Materials Methods: Before occluding aorta for 45 mins by inflating intravascular balloons, randomly infused either (n = 8; 300 IU/kg each over 30 before during first 4 hrs of reperfusion) or...
Objective: To test the hypothesis whether pure oxygen ventilation is equally safe and beneficial in fully developed fecal peritonitis-induced septic shock as hyperoxia initiated at induction of sepsis. Design: Prospective, randomized, controlled, experimental study with repeated measures. Setting: Animal research laboratory a university medical school. Subjects: Twenty anesthetized, mechanically ventilated, instrumented pigs. Interventions: Twelve hours after peritonitis by inoculation...
Aims To estimate if chronic anticoagulant (CAC) treatment is associated with morbidity and mortality outcomes of patients hospitalized for SARS-CoV-2 infection. Methods In this European multicentric cohort study, we included 1186 whom 144 were on CAC (12.1%) positive coronavirus disease 2019 testing between 1 February 30 July 2020. The average effect (ATE) analysis a propensity score-matching (PSM) algorithm was used to the impact primary defined as in-hospital death, major minor bleeding...
The majority of intensive care physicians recognize the clinical significance intra-abdominal hypertension on outcome critically ill patients. Abdominal compartment syndrome (ACS) is defined as an pressure (IAP) >20 mmHg with ongoing organ failure. However, there no consensus regarding indications for surgical decompression.A review personal data and English literature from 1989 to 2010 focusing management ACS.Opening abdomen most effective method reduce IAP treatment choice ACS when...
Objective: To better clarify the pathogenesis of linezolid-induced lactic acidosis. Design: Case report. Setting: ICU. Patient: A 64-year-old man who died with Interventions: Skeletal muscle was sampled at autopsy to study mitochondrial function. Measurements and Main Results: Lactic acidosis developed during continuous infusion linezolid while oxygen consumption extraction were diminishing from 172 52 mL/min/m 2 0.27 0.10, respectively. Activities skeletal respiratory chain complexes I,...
The role of upper airways microbiota and its association with ventilator-associated pneumonia (VAP) development in mechanically ventilated (MV) patients is unclear. Taking advantage data collected a prospective study aimed to assess the composition over-time variation airway MV for non-pulmonary reasons, we describe characteristics among VAP NO-VAP patients.Exploratory analysis observational on intubated conditions. Microbiota (trough 16S-rRNA gene profiling) was performed endotracheal...
Impairment of ventilation and perfusion (V/Q) matching is a common mechanism leading to hypoxemia in patients with acute respiratory failure requiring intensive care unit (ICU) admission. While has been thoroughly investigated, little progress made monitor pulmonary at the bedside treat impaired blood distribution. The study aimed assess real-time changes regional response therapeutic intervention.Single-center prospective that enrolled adult ARDS caused by SARS-Cov-2 who were sedated,...
We study the microbunching instability in a bunch compressor by parallel code with some improved numerical algorithms. The two-dimensional charge/current distribution is represented Fourier series, coefficients determined through Monte Carlo sampling over an ensemble of tracked points. This gives globally smooth low noise. field equations are solved accurately lab frame using retarded potentials and novel choice integration variables that eliminates singularities. apply scheme parameters for...
Abstract Background External chest-wall compression (ECC) is sometimes used in ARDS patients despite lack of evidence. It currently unknown whether this practice has any clinical benefit with COVID-19 (C-ARDS) characterized by a respiratory system compliance ( C rs ) < 35 mL/cmH 2 O. Objectives To test if an ECC 5 L-bag low-compliance C-ARDS can lead to reduction driving pressure (DP) and improve gas exchange, understand the underlying mechanisms. Methods Eleven were enrolled underwent 4...
Patients admitted to the intensive care unit greatly differ in severity and intensity of care. We devised a system for selecting high-risk patients that reduces bias by excluding low-risk with an early death irrespective treatment.A posteriori analysis multiple-center prospective observational trial.A total 89 units from 12 European countries, 12,615 patients.Demographic clinical data: illness at admission, daily score nursing workload, length stay, hospital mortality.We enrolled stay >24...
A novel algorithm for self-consistent simulations of long-range wakefield effects has been developed and applied to the study both longitudinal transverse coupled-bunch instabilities at NSLS-II. The is implemented in new parallel tracking code space (self-consistent collective effects) discussed paper. applicable accurate beam dynamics cases where bunch-to-bunch intrabunch motions need be taken into account, such as chromatic head-tail on instability a with nonuniform filling pattern, or...
Impedance modeling for accelerator applications has improved over the years, largely as a result of advances in simulation capabilities. While this been successful reproducing certain measurements, it is still significant challenge to predict collective effects real machines. In paper, we review our approach impedance and subsequent simulations effects. We discuss choice electrodynamics codes required computer power resources, geometric, resistive wall impedances, their comparison with...