A5072664078- Respiratory Support and Mechanisms
- Cardiac Arrest and Resuscitation
- Intensive Care Unit Cognitive Disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Neurosurgical Procedures and Complications
- Acute Kidney Injury Research
- COVID-19 and healthcare impacts
- Pancreatitis Pathology and Treatment
- COVID-19 Clinical Research Studies
- Cystic Fibrosis Research Advances
- Intracerebral and Subarachnoid Hemorrhage Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Thermal Regulation in Medicine
- Electrolyte and hormonal disorders
- COVID-19 diagnosis using AI
- Abdominal Surgery and Complications
- Renal function and acid-base balance
- Cardiac Ischemia and Reperfusion
- Pleural and Pulmonary Diseases
- COVID-19 epidemiological studies
- Non-Invasive Vital Sign Monitoring
- Cardiovascular and Diving-Related Complications
- Fuel Cells and Related Materials
- Teratomas and Epidermoid Cysts
- Muscle and Compartmental Disorders
Massachusetts General Hospital
2019-2025
Harvard University
2020-2025
Boston University
2024-2025
Mayo Clinic Hospital
2024
Neurological Surgery
2024
Mayo Clinic in Florida
2024
WinnMed
2024
Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda
2020-2023
University of Milano-Bicocca
2015-2023
Azienda Regionale Emergenza Urgenza
2020-2023
Changing trunk inclination affects lung function in patients with ARDS. However, its impacts on PEEP titration remain unknown. The primary aim of this study was to assess, mechanically ventilated COVID-19 ARDS, the effects titration. secondary compare respiratory mechanics and gas exchange semi-recumbent (40° head-of-the-bed) supine-flat (0°) positions following titration.Twelve were positioned both at 40° 0° (randomized order). associated best compromise between overdistension collapse...
Background: Methicillin-resistant Staphylococcus aureus (MRSA) is a significant cause of healthcare-associated infections in Europe. It has become increasingly prevalent community settings, causing skin and soft tissue (SSTIs). Managing community-acquired (CA) MRSA challenging due to its high virulence resistance common antibiotics, prevention outside the hospital setting complex. Combination therapy demonstrated efficacy treatment severe infections. Furthermore, surgical source control...
The superimposed pressure is the primary determinant of pleural gradient. Obesity associated with elevated end-expiratory esophageal pressure, regardless lung disease severity, and might not be only study aims to measure partitioned respiratory mechanics in a cohort patients admitted ICU without class III obesity (BMI ≥ 40 kg/m
Abstract Introduction the current worldwide outbreak of Coronavirus disease 2019 (COVID-19) due to a novel coronavirus (SARS-CoV-2) is seriously threatening public health. The number infected patients continuously increasing and need for Intensive Care Unit admission ranges from 5 26%. mortality reported be around 3.4% with higher values elderly in comorbidities. Moreover, this condition challenging healthcare system where reached its highest value. To date there still no available treatment...
Introduction Postoperative acute kidney injury (AKI) is a common complication in cardiac surgery. Levels of intravascular haemolysis are strongly associated with postoperative AKI and prolonged (>90 min) use cardiopulmonary bypass (CPB). Ferrous plasma haemoglobin released into the circulation acts as scavenger nitric oxide (NO) produced by endothelial cells. Consequently, vascular bioavailability NO reduced, leading to vasoconstriction impaired renal function. In patients cardiovascular...
Background . Individuals with cystic fibrosis (CF) have persistent lung infections, necessitating the frequent use of antibiotics for pulmonary exacerbations. Some respiratory pathogens intrinsic resistance to currently available antibiotics, and any pathogen may acquire over time, posing a challenge CF care. Gaseous nitric oxide has been shown antimicrobial activity against wide variety microorganisms, including common pathogens, offers potential inhaled therapy. Case Presentation Here, we...
Abstract Objective To quantify how the first public announcement of confirmed coronavirus disease 2019 (COVID‐19) in Italy affected a metropolitan region's emergency medical services (EMS) call volume and rapid introduction alternative procedures at safety answering point (PSAP) managed system resources. Methods PSAP processes were modified over several days including (1) referral non‐ill callers to health information centers; (2) algorithms for detection, isolation, or hospitalization...
Abstract Background External chest-wall compression (ECC) is sometimes used in ARDS patients despite lack of evidence. It currently unknown whether this practice has any clinical benefit with COVID-19 (C-ARDS) characterized by a respiratory system compliance ( C rs ) < 35 mL/cmH 2 O. Objectives To test if an ECC 5 L-bag low-compliance C-ARDS can lead to reduction driving pressure (DP) and improve gas exchange, understand the underlying mechanisms. Methods Eleven were enrolled underwent 4...
Impairment of ventilation and perfusion (V/Q) matching is a common mechanism leading to hypoxemia in patients with acute respiratory failure requiring intensive care unit (ICU) admission. While has been thoroughly investigated, little progress made monitor pulmonary at the bedside treat impaired blood distribution. The study aimed assess real-time changes regional response therapeutic intervention.Single-center prospective that enrolled adult ARDS caused by SARS-Cov-2 who were sedated,...
<h3>BACKGROUND:</h3> A lung-protective mechanical ventilation strategy has become the hallmark of management for patients with acute respiratory failure. However, some progress to more severe forms failure refractory hypoxemia. In such circumstances, individualized titration according patient9s specific and cardiovascular pathophysiology is desirable. lung rescue team (LRT) was recently established at our institution improve medical care when conventional treatment fails. The aim this report...
Intracerebral hemorrhage (ICH) admitted to Intensive Care is deem of poor prognosis. The aim this study was compare observed and predicted 30-day mortality evaluate long term functional outcome in a consecutive ICH cohort.Retrospective analysis prospectively collected data patients managed Neuro-ICU from 2012 2015.Out 136 patients, 34 (25%) had "withholding life-sustaining treatment" (WLST) order 102 (75%) received "full (FT). WLST cohort: median (IQR): 72 (70-77) years old, Glasgow Coma...
The regional emergency medical service (EMS) in Lombardy (Italy) developed clinical algorithms based on operator-based interviews to detect patients with COVID-19 and refer them the most appropriate hospitals. Machine learning (ML)-based models using additional geospatial epidemiological data may improve identification of infected guide EMS detecting cases before confirmation SARS-CoV-2 reverse transcriptase PCR (rtPCR).This was an observational, retrospective cohort study from October 2020...
Brain-injured patients frequently require tracheostomy, but no technique has been shown to be the gold standard for these patients. We developed and introduced into clinical practice an innovative bedside translaryngeal tracheostomy (TLT) aided by suspension laryngoscopy (modified TLT). During this procedure, endotracheal tube is left in place until airway secured with new tracheostomy. This study assessed impact of brain-injured patients.This a retrospective analysis prospectively collected...