A5062160845- Particle Accelerators and Free-Electron Lasers
- Particle accelerators and beam dynamics
- Superconducting Materials and Applications
- Distributed and Parallel Computing Systems
- Genomics and Phylogenetic Studies
- Structural Engineering and Vibration Analysis
- Gyrotron and Vacuum Electronics Research
- Engineering Applied Research
- Advanced Data Storage Technologies
- Advanced X-ray Imaging Techniques
- Railway Engineering and Dynamics
- Gene expression and cancer classification
- Molecular Biology Techniques and Applications
- Photocathodes and Microchannel Plates
- Parallel Computing and Optimization Techniques
- Magnetic confinement fusion research
- Optical Imaging and Spectroscopy Techniques
- Thermoregulation and physiological responses
- Genomics and Chromatin Dynamics
- Cancer Genomics and Diagnostics
- Astronomical Observations and Instrumentation
- Industrial Automation and Control Systems
- RNA and protein synthesis mechanisms
- Embedded Systems and FPGA Design
- Single-cell and spatial transcriptomics
Korea Research Institute of Bioscience and Biotechnology
2016-2024
Kosin University Gospel Hospital
2023
Brookhaven National Laboratory
2012-2022
Herrick District Library
2015
Daelim University College
2015
Pohang University of Science and Technology
2005-2013
Pohang Accelerator Laboratory
2005-2013
Brookhaven College
2013
Pohang TechnoPark (South Korea)
2006
Three-dimensional (3D) chromatin structure is an emerging paradigm for understanding gene regulation mechanisms. Hi-C (high-throughput conformation capture), a method to detect long-range interactions, allows extensive genome-wide investigation of 3D structure. However, broad application data have been hindered by the level complexity in processing and large size raw sequencing data. In order overcome these limitations, we constructed database named 3DIV (a 3D-genome Interaction Viewer...
Hibiscus syriacus (L.) (rose of Sharon) is one the most widespread garden shrubs in world. We report a draft H. genome comprised 1.75 Gb assembly that covers 92% with only 1.7% (33 Mb) gap sequences. Predicted gene modeling detected 87,603 genes, mostly supported by deep RNA sequencing data. To define family distribution among relatives syriacus, orthologous sets containing 164,660 genes 21,472 clusters were identified OrthoMCL analysis five plant species, including Arabidopsis thaliana,...
Three-dimensional (3D) genome organization is tightly coupled with gene regulation in various biological processes and diseases. In cancer, types of large-scale genomic rearrangements can disrupt the 3D genome, leading to oncogenic expression. However, unraveling pathogenicity cancer remains a challenge since closer examinations have been greatly limited due lack appropriate tools specialized for disorganized higher-order chromatin structure. Here, we updated 3D-genome Interaction Viewer...
After 14 years of successful operation, the Pohang Light Source (PLS) has completed PLS-II upgrade to meet increasing demand from growing user community. The increased beam energy 2.5 GeV 3 GeV; number insertion devices been by a factor two (20 IDs); and current 400 mA 200 mA. emittance reduced below 10 nm while retaining existing PLS tunnel as well injection system. During six months commissioning in latter half 2011, we have successfully achieved device operations top-up with 100 5.8...
A wave of new technologies has created opportunities for the cost-effective generation high-throughput profiles biological systems, foreshadowing a "data-driven science" era. The large variety data available from research is also rich resource that can be used innovative endeavors. However, we are facing considerable challenges in big deposition, integration, and translation due to complexity its production at unprecedented exponential rates. To address these problems, 2020, Korean...
Abstract During the last decade, generation and accumulation of petabase-scale high-throughput sequencing data have resulted in great challenges, including access to human data, as well transfer, storage, sharing enormous amounts data. To promote data-driven biological research, Korean government announced that all generated from government-funded research projects should be deposited at Korea BioData Station (K-BDS), which consists multiple databases for individual types. Here, we introduce...
Abstract High-throughput screening based on CRISPR-Cas9 libraries has become an attractive and powerful technique to identify target genes for functional studies. However, accessibility of public data is limited due the lack user-friendly utilities up-to-date resources covering experiments from third parties. Here, we describe iCSDB, integrated database CRISPR using human cell lines. We compiled two major sources screening: DepMap portal BioGRID ORCS. itself that includes three large-scale...
Cancer cell lines are essential components for biomedical research. However, proper choice of experimental purposes is often difficult because genotype and/or expression data missing or scattered in diverse resources. Here, we report Gene Expression and Mutations Cell Lines (GEMiCCL), an online database human cancer that provides information. We have collected mutation, gene copy number variation (CNV) from three representative databases on lines—Cancer Line Encyclopedia , Catalogue Somatic...
Abstract Human pluripotent stem cell (hPSC)-derived organoids and cells have similar characteristics to human organs tissues. Thus, in vitro serve as a superior alternative conventional lines animal models drug development regenerative medicine. For simple reproducible analysis of the quality compensate for shortcomings existing experimental validation studies, quantitative evaluation method should be developed. Here, using GTEx database, we construct calculation system assess similarity...
The domestic dog, Canis lupus familiaris, is a companion animal for humans as well an model in cancer research due to similar spontaneous occurrence of cancers humans. Despite the social and biological importance dogs, catalogue genomic variations transcripts dogs relatively incomplete.We developed CanISO, new database hold large collection transcriptome profiles dogs. CanISO provides 87,692 novel transcript isoforms 60,992 known from whole sequencing canine tumors (N = 157) their matched...
We describe the status of plans to build an Energy-Recovery Linac (ERL) X-ray facility at Cornell University. This 5 GeV ERL is upgrade CESR ring that currently powers High Energy Synchrotron Source (CHESS) [1]. Due its very small electron-beam emittances, it would dramatically improve capabilities light source and result in beams orders magnitude better than any existing storage-ring source. The emittances are based upon simulations for currents competitive with ring-based sources [2, 4]....
In our previous publications, we introduced a concept of complex bend, which is bending element consisting dipole poles, interleaved with strong focusing and defocusing quadrupole poles. An electron ring built from such elements features low emittance while preserving substantial room for insertion devices associated lattice elements. this paper, present two new optics solutions the bend offer to substantially reduce device length by removing first solutions, realized shifting poles along...
The first multi-span suspension bridge which crosses a strait in Korea was constructed and opened to traffic 2019. is located on the southwest coast of famous for magnificent view Dadohae. It notable this introduce some ingenious technologies like PPWS main cable (breaking stress 1960 MPa), in-marine anchorage with composite foundation, high-performance steel. Also, graceful curve line enables harmonize surrounding landscape. Together bridge, already had two large bridges—one span 1,545m...
The first eight insertion devices (IDs) at the NSLS-II were commissioned during fall run of 2014. In this paper we discuss commissioning synchrotron radiation protection (SRP) system and beamline frontends (FE) for respective IDs. We describe diagnostics utilized if FE a procedure that was used alignment photon beam from in frontends. Then current status SRP operation
The National Synchrotron Light Source II (NSLS-II) is a state of the art 3 GeV third generation light source at Brookhaven Laboratory. During spring/ summer 2014, storage ring was commissioned up to 50 mA without insertion devices. In fall we began commissioning project beamlines, which included seven devices on six ID ports. Beamlines IXS, HXN, CSX-1, CSX-2, CHX, SRX, and XPD-1 consist elliptically polarized undulator (EPU), damping wigglers (DW) in-vacuum undulators (IVU) covering from VUV...
The National Synchrotron Light Source II at Brookhaven Lab is a third-generation synchrotron radiation facility that has been commissioned in 2014. based on 3 GeV electron storage ring, which will circulate 500 mA of beam current 1 nm rad horizontal emittance. ring 792 meters circumference and accommodate more than 60 beamlines the final built-out. beamline sources range from insertion-devices located straight sections, bending magnets or three-pole-wigglers configured multiple branches....
Laser speckle contrast imaging (LSCI) can achieve real-time 2D perfusion maps non-invasively. However, LSCI is still difficult to use in general clinical applications because of movement sensitivity and limitations blood flow analysis. To overcome this, fluorescence (FI) combined with using a light source wavelength 785 nm near-infrared (NIR) region validates visualize perfusion. The system was performed Intralipid indocyanine green (ICG) phantom that has three tubes controlled the rate...