A5100671470- Genomics and Phylogenetic Studies
- Skin Protection and Aging
- melanin and skin pigmentation
- Biochemical Analysis and Sensing Techniques
- Molecular Biology Techniques and Applications
- Ion channel regulation and function
- Cancer, Hypoxia, and Metabolism
- Gene expression and cancer classification
- Bioactive Compounds and Antitumor Agents
- IL-33, ST2, and ILC Pathways
- Cellular Mechanics and Interactions
- Metabolism, Diabetes, and Cancer
- Asthma and respiratory diseases
- Dermatology and Skin Diseases
- Microtubule and mitosis dynamics
- Enzyme Catalysis and Immobilization
- RNA modifications and cancer
- Amino Acid Enzymes and Metabolism
- Bioinformatics and Genomic Networks
- Machine Learning in Bioinformatics
- Coenzyme Q10 studies and effects
- Microbial infections and disease research
- Bacteriophages and microbial interactions
- Protein Structure and Dynamics
- Enzyme Structure and Function
Korea Research Institute of Bioscience and Biotechnology
2020-2023
Yonsei University
2015-2023
Korea Polar Research Institute
2023
Kangwon National University
2021-2022
The expression levels of anoctamin 1 (ANO1, TMEM16A), a calcium-activated chloride channel (CaCC), are significantly increased in several tumors, and inhibition ANO1 is known to reduce cell proliferation migration. Here, we performed cell-based screening collection natural products drug-like compounds identify inhibitors ANO1. As result the screening, idebenone, miconazole plumbagin were identified as novel inhibitors. Electrophysiological studies showed that synthetic analog coenzyme Q10,...
Spatial transcriptomics holds great promise for revolutionizing biology and medicine by providing gene expression profiles with spatial information. Until recently, resolution has been limited, but advances in high-throughput situ imaging technologies now offer new opportunities covering thousands of genes at a single-cell or even subcellular resolution, necessitating databases dedicated to comprehensive coverage analysis user-friendly intefaces. We introduce the HISSTA database, which...
The domestic dog, Canis lupus familiaris, is a companion animal for humans as well an model in cancer research due to similar spontaneous occurrence of cancers humans. Despite the social and biological importance dogs, catalogue genomic variations transcripts dogs relatively incomplete.We developed CanISO, new database hold large collection transcriptome profiles dogs. CanISO provides 87,692 novel transcript isoforms 60,992 known from whole sequencing canine tumors (N = 157) their matched...
PsEst3, a psychrophilic esterase obtained from Paenibacillus sp. R4, which was isolated the permafrost of Alaska, exhibits relatively high activity at low temperatures. Here, crystal structures PsEst3 complexed with various ligands were generated and studied atomic resolution, biochemical studies performed to analyze structure–function relationship PsEst3. Certain unique characteristics distinct those other classes lipases/esterases identified. Firstly, contains conserved GHSRA/G...
Functional analyses of genes are crucial for unveiling biological responses, genetic engineering, and developing new medicines. However, functional have largely been restricted to model organisms, representing a major hurdle studies industrial applications. To resolve this, comparative genome can be used provide clues gene functions as well their evolutionary history. this end, we present Prometheus, web-based omics portal that contains more than 17,215 sequences from prokaryotic eukaryotic...
Epithelial-to-mesenchymal transition (EMT)-subtype gastric cancers have the worst prognosis due to their higher recurrence rate, probability of developing metastases and chemoresistance compared those other molecular subtypes. Pharmacologically actionable somatic mutations are rarely found in EMT-subtype cancers, limiting utility targeted therapies. Here, we conducted a high-throughput chemical screen using 37 cancer cell lines 48,467 synthetic smallmolecule compounds. We identified YK-135,...