A5052371372- RNA modifications and cancer
- Circular RNAs in diseases
- Galectins and Cancer Biology
- Cancer-related Molecular Pathways
- Cancer-related molecular mechanisms research
- Retinal Diseases and Treatments
- MicroRNA in disease regulation
- Cancer, Lipids, and Metabolism
- Blood disorders and treatments
- Natural product bioactivities and synthesis
- Neutropenia and Cancer Infections
- Kruppel-like factors research
- Cancer, Hypoxia, and Metabolism
- Cytokine Signaling Pathways and Interactions
- Lung Cancer Research Studies
- Epigenetics and DNA Methylation
- Retinal Imaging and Analysis
- interferon and immune responses
- Ginseng Biological Effects and Applications
- Monoclonal and Polyclonal Antibodies Research
- Retinal and Optic Conditions
- Cancer-related gene regulation
- HER2/EGFR in Cancer Research
- Glycosylation and Glycoproteins Research
- Cancer Mechanisms and Therapy
Shanghai Jiao Tong University
2016-2023
Ningxia University
2021-2022
Harbin Institute of Petroleum
2021
Wenzhou Medical University
2021
Dongyang People's Hospital
2021
China Pharmaceutical University
2017-2019
Albert Einstein College of Medicine
2014-2017
China International Science and Technology Cooperation
2016
Chongqing Medical University
2016
China National Nuclear Corporation
2016
cGAS-STING signaling is essential for innate immunity. Its misregulation promotes cancer or autoimmune and autoinflammatory diseases, it imperative to identify effective lead compounds that specifically downregulate the pathway. We report here astin C, a cyclopeptide isolated from medicinal plant Aster tataricus, inhibits inflammatory responses triggered by cytosolic DNAs. Moreover, mice treated with C are more susceptible HSV-1 infection. Consistently, markedly attenuates in Trex1-/- BMDM...
Abstract Background Circular RNAs (circRNAs) play a critical regulatory role in cancer progression. However, the underlying mechanisms of circRNAs hepatocellular carcinoma (HCC) metastasis remain mostly unknown. Methods Has_circ_0003998 (circ0003998) was identified by sequencing HCC patients with /without portal vein tumor thrombus (PVTT) metastasis. The expression level circ0003998 further detected situ hybridization on tissues microarray (ISH-TMA) and qRT-PCR 25 PVTT Moreover, 50 without...
Abstract Human rhinovirus (HRV) causes the common cold. The most acute infection in humans, HRV is a leading cause of exacerbations asthma and chronic obstruction pulmonary disease because its ability to exacerbate airway inflammation by altering epithelial cell biology upon binding receptor, ICAM-1. ICAM-1 regulates not only viral entry replication but also signaling pathways that lead inflammatory mediator production. We recently demonstrated Syk tyrosine kinase be an important HRV-ICAM-1...
Abstract Colorectal cancer (CRC) is the third most prevalent and highest cancer-related mortality in United States. Bigelovin, a sesquiterpene lactone isolated from Inula helianthus aquatica , has been proven to induce apoptosis exhibit anti-inflammatory anti-angiogenic activities. However, effects of bigelovin on CRC underlying mechanisms have not explored. The present study demonstrated that exhibited potent anti-tumor activities against vitro vivo . Bigelovin suppressed cell proliferation...
Liver cancer is a progressive, irreversible and aggressive malignant disease, which has no effective chemotherapeutic drugs. RA-XII, natural cyclopeptide isolated from the traditional Chinese medicine Rubia yunnanensis, exerts anti-cancer anti-inflammatory activities. This work aimed to investigate effects of RA-XII on hepatic tumor its underlying mechanisms in human hepatoma HepG2 cells. The results showed that effectively inhibited proliferation Consistently, significantly induced...
γ-Aminobutyric acid (GABA) is a natural non-protein amino acid, which broadly exists in many plant parts and widely used as an ingredient the food industry. In mammals, it distributed central nervous system non-neural tissues. addition to primary inhibitory neurotransmitter system, endogenous GABA content has been found be elevated neoplastic tissues colon cancer. However, effect of extraneous on cancer rarely reported. this study, we effects proliferation cells (CCCs). The also suppressed...
Persistent infection with high‑risk human papillomavirus is known to cause cervical cancer. The binding of the costimulatory factors, Tim‑3 and galectin‑9, can immune tolerance lead escape during carcinogenesis. Epigenetic regulation essential for Tim‑3/galectin‑9 expression, which affects outcome local cancer infection. Hence, exploring epigenetic regulatory mechanisms signaling by great interest investigating through these proteins are regulated in tumorigenesis. In this study, we report...
Abstract Rubiaceae-type cyclopeptides (RAs) are a type of plant from the Rubia that have garnered significant attention owing to their unique bicyclic structures and amazing antitumour activities. Our recent work has shown RAs suppress inflammation angiogenesis induce apoptosis. However, underlying mechanism targets remained unknown. Nuclear factor κB (NF-κB) signaling pathway plays critical role in these biological processes, prompting us investigate whether how affect this pathway. By...
Abstract Background Methylation of histone 3 at lysine 9 (H3K9) and DNA methylation are epigenetic marks correlated with genes silencing. The tumor microenvironment significantly influences therapeutic responses clinical outcomes. epigenetic-regulation mechanism the costimulatory factors Tim-3 galectin-9 in cervical cancer remains unknown. Methods status HAVCR2 LGALS9 were detected by MS-PCR tissues cell lines. underlying molecular SUV39H1-DNMT3A-Tim-3/galectin-9 regulation was elucidated...
// Yi Huang 1, * , Meihua Yang 2, Huajian Hu 3, Xiaodong Zhao 1 Liming Bao 4 Daochao 5 Lihua Song 6 Li Chongqing Key Laboratory of Child Infection and Immunity, Children's Hospital Medical University, Ministry Education Development Disorders, China International Science Technology Cooperation Base Critical 400014, PR 2 Department Neurosurgery, Xinqiao Third Military 400038, 3 Gastroenterology, Pathology, Dartmouth-Hitchcock Center, Geisel School Medicine at Dartmouth College, Lebanon, NH...
The Hippo pathway restricts organ size during development and its inactivation plays a crucial role in cancer. Yes-associated protein (YAP) paralog transcriptional coactivator with PSD-95/Dlg/ZO-1 (PDZ)-binding motif (TAZ) are transcription co-activators effectors of the mediating aberrant enlargement organs tumor growth upon inactivation. It has been demonstrated that genetic YAP could be an effective approach to inhibit tumorigenesis. In order identify pharmacological inhibitors YAP, we...
The master tumor suppressor p53 activates transcription in response to various cellular stresses part by facilitating recruitment of the machinery DNA. Recent studies have documented a direct yet poorly characterized interaction between and RNA polymerase II (Pol II). Therefore, we dissected human p53/Pol via single-particle cryo-electron microscopy, structural docking, biochemical analyses. This study reveals that binds Pol Rpb1 Rpb2 subunits, bridging DNA-binding cleft proximal upstream...
Lipogenesis plays a critical role in the growth and metastasis of tumors, which is becoming an attractive target for anti-tumor drugs. RA-XII, one cyclopeptide glycosides isolated from
Abstract Background Whether routine lymph node dissection for early endometrial cancer is beneficial to survival still controversial. However, surgeons usually perform on all patients with cancer. This study aimed prove that the risk of metastasis, as defined by our standard, very low in such and may change current surgical practice. Methods 36 consecutive who had staged surgery were collected. All eligible meet following criteria including: (1) preoperative diagnosis (preoperative...
Naphthohydroquinone dimers isolated from Rubia plants have garnered more attention due to their distinctive chemical structures and intriguing bioactivities. In our previous studies, we obtained ten naphthohydroquinone containing seven novel ones found that most of them possessed anti-tumor activities, especially rubioncolin C. However, the underlying mechanism remains unknown. this study, focused on C it could inhibit growth cancer cell lines with IC50 values between 1.14 9.93 μM. Further...
Chinese jujube (Ziziphus jujuba Mill.) is an economically important fruit tree with outstanding adaptability to marginal lands and a broad range of climate conditions. There are over 800 cultivars, mostly landraces from China. However, high rate mislabeling in germplasm restricts the sharing information materials among researchers hampers use breeding. In present study, we developed large panel single nucleotide polymorphism (SNP) markers validated 288 SNPs by genotyping 114 accessions...
Human epidermal growth factor receptor 2 (HER2) is one of the most studied tumor-associated antigens for cancer immunotherapy. An engineered anti-HER-2 chimeric A21 antibody (chA21) a targeted to subdomain I HER2 extracellular domain. Here, we report anti-tumor activity novel monoclonal humanized chA21 (HuA21) that targets on basis chA21, and describe underlying mechanisms. Our results reveal HuA21 markedly inhibits proliferation migration HER2-overexpressing breast cells causes enhanced...
Background: Smad3 is a pivotal intracellular mediator for participating in the activation of multiple immune signal pathway. Objective: The epigenetic regulation mechanism positive factor cervical cancer remains unknown. Therefore, on investigated this study. Methods: methylation status SMAD3 was detected by Methylation-specific PCR (MS-PCR) and Quantitative (MS-qPCR) tissues cell lines. underlying molecular mechanisms SUV39H1-DNMT1-Smad3 elucidated using lines containing siRNA or/and...