A5084628330- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Cancer Immunotherapy and Biomarkers
- Microbial Natural Products and Biosynthesis
- Cancer Diagnosis and Treatment
- Cervical and Thoracic Myelopathy
- Bone health and treatments
- Medical Imaging and Analysis
- SARS-CoV-2 and COVID-19 Research
- Radiomics and Machine Learning in Medical Imaging
- Esophageal Cancer Research and Treatment
- Bone Metabolism and Diseases
- Brain Metastases and Treatment
- Geomechanics and Mining Engineering
- Cancer-related cognitive impairment studies
- Management of metastatic bone disease
- Marine Sponges and Natural Products
- Scoliosis diagnosis and treatment
- COVID-19 and healthcare impacts
- Vitamin D Research Studies
- Diagnosis and Treatment of Venous Diseases
- COVID-19 Clinical Research Studies
- Venous Thromboembolism Diagnosis and Management
- Childhood Cancer Survivors' Quality of Life
- Occupational Health and Safety Research
Shantou University
2009-2025
Second Affiliated Hospital of Shantou University Medical College
2005-2025
Cancer Hospital of Shantou University Medical College
2021-2025
Southeast University
2024
China Pharmaceutical University
2022-2024
State Grid Corporation of China (China)
2024
Shanghai Electric (China)
2023
Shantou University Medical College
2008-2023
Sun Yat-sen Memorial Hospital
2022
Sun Yat-sen University
2022
Thirteen new sativene sesquiterpenoids (1 and 3–14), one natural product (2), 16 known compounds (15–30) were isolated from the endophytic fungus Bipolaris victoriae S27. Their structures elucidated by extensive spectroscopic analysis, NMR ECD calculations, X-ray crystal diffractions. Compound 1 represented first example of with a 6/5/3/5-caged tetracyclic ring system. All obtained evaluated for their plant-growth regulatory activity. The results showed that 1, 3, 4, 6, 8, 11, 12, 17, 19,...
Osteopontin (OPN) has been proved to be closely related the pathogenesis of osteoarthritis (OA), but role OPN in OA not fully clarified. Current studies on mostly focus articular cartilage, synovial membrane and fluid, while ignoring its subchondral bone turnover remodeling. In this study, we used a destabilization mouse model investigate changes. Our results indicate that increased expression accelerates remodeling bone, promotes formation h-type vessels mediates cartilage degeneration...
Background We investigated whether 1-year trajectories of cancer-related cognitive decline (CRCD) would be different in patients with chemotherapy combined immune checkpoint inhibitors (chemoICI group) as compared alone (chemo group). Methods Participants scheduled or without ICI were prospectively recruited from three academic hospitals and followed up for 1 year four sessions. Subjective objective CRCD measured by Perceived Cognitive Impairment (PCI) Montreal Assessment (MoCA),...
Neoadjuvant checkpoint blockade immunotherapy (NATI) significantly prolonged outcomes for triple-negative breast cancer (TNBC). Residual tumor cells that survive NATI represent high-risk cell populations with metastatic potential and usually evade immunosurveillance by NK cells. Using an 82-protein panel, we here profiled single-cell membrane proteomics of CD56+ (NCAM1+) from tumor, peri-cancerous tissue, as well peripheral blood 28 TNBC patients post-NATI residual burden II/III....
Background Patients with cancer on active immune checkpoint inhibitors therapy were recommended to seek prophylaxis from COVID-19 by vaccination. There have been few reports date discuss the impact of progression cell death-1 blockers (PD-1B) or vaccine-related outcomes, and what risk factors that contribute serological status remains be elucidated. The study aims find PD-1B vaccination outcome investigate other potential associated seroconversion failure. Methods treatment retrospectively...
A three-dimensional study of the thoracic pedicle (T1-T12) morphometry in Chinese patients with different body height, using reformatted computed tomography (CT).To quantify dimensions pedicles and to analyze relationship between height parameters.The has been studied extensively populations various techniques. Previous studies have shown a significantly smaller size women than men Asians Caucasians. Some authors postulated that it is contributes variation size. To our knowledge, however, no...
Osteoporosis is a condition associated with osteolytic bone disease that primarily characterized by inordinate osteoclast activation. Protein kinase B (Akt) pathways activated receptor activator of nuclear factor kappa-B ligand (RANKL) are essential for osteoclastogenesis. Asiatic acid (AA) natural pentacyclic triterpenoid compound extracted from traditional Chinese herb exhibits wide range biological activities. AA has been found to alleviate the hypertrophic and fibrotic phenotype...
Two highly oxygenated pentacyclic polyketides with two new carbon skeletons, trichopsistide A (1) and B (2), were isolated from the plant endophyte Trichoderma koningiopsis WZ-196 derived leaf of Rubia podantha Diels. The structures these full configurations determined by comprehensive spectroscopic analysis, computer-assisted structure elucidation software, computational calculation, X-ray crystal diffraction. Among them, 1 represented first example an unprecedented 5/6/6/6/5...
This study assessed the efficacy, safety, pharmacokinetics (PK), and immunogenicity profiles of a denosumab biosimilar (LY06006) in Chinese postmenopausal osteoporotic women with high risk fracture.In this multicenter, randomized, double-blind, placebo-controlled, phase 3 trial, 448 aged 50-85 years osteoporosis were enrolled at 49 centers China randomly assigned (3:1) to receive 60 mg or placebo subcutaneously every 6 months for 1 year. Lumbar spine bone mineral density (BMD) change was...
The aim of this study was to investigate the detailed three-dimensional morphology pedicles from T1 T12 in 120 Chinese patients using a light-speed Vct CT (General Electric). After reformatting original images, following parameters were studied: outer pedicle width (OPW), height (OPH), chord length (PCL), cortical thickness (PCT) isthmus, and transverse angle (TPA). mean width, height, significantly smaller females than males at all levels (P < 0.01). percentage ≤ 5.0 mm 4.5 high...
The Electric Bike (EB) has become an ideal mode of transportation because its simple operation, convenience, and it is time saving, economical environmentally friendly. However, electric bicycle road-traffic injuries (ERTIs) have a safety problem that needs to be solved urgently, bringing huge burden public health. In order provide basic data theoretical basis for the prevention control ERTIs in Shantou, mixed research combining case-control study case-crossover was carried out investigate...
Introduction Although there is extended research on the response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines in adult cancer patients (ACP), immunogenicity variants of concern (VOCs) childhood (CCP) and safety profiles are now little known. Methods A prospective, multi-center cohort study was performed by recruiting children with a solid diagnosis healthy control (CHC) receive standard two-dose SARS-CoV-2 vaccines. An independent ACP group included match CCP...
Purpose Due to the poor and unpredictable prognosis of breast cancer (BC) patients with bone metastasis, it is necessary find convenient available prognostic predictors. This study aimed recognize clinical factors related laboratory examination construct a nomogram for BC metastasis.Methods We retrospectively analyzed 32 candidate indicators from features data 276 metastasis. Univariate multivariate regression analyses were performed identify significant Nomogram was constructed estimated by...
Software-Defined Networking (SDN) enhances network control but faces Distributed Denial of Service (DDoS) attacks due to centralized and flow-table constraints in devices. To overcome this limitation, we introduce a multi-path routing algorithm for SDN called Trust-Based Proximal Policy Optimization (TBPPO). TBPPO incorporates Kullback–Leibler divergence (KL divergence) trust value node diversity mechanism as the security assessment criterion, aiming mitigate issues such fluctuations, low...
Deep vein thrombosis (DVT) often occurs following major orthopedic surgery. In this study, we investigated specific exosomal proteins as potential diagnostic biomarkers of DVT.Proteomic analysis exosomes from four DVT patients and healthy controls (n=4) was performed by mass spectrometry. The model animals were evaluated at 1 inferior vena cava ligation [(IVCL)-1D], 3 (IVCL-3D), 7 (IVCL-7D) days after IVCL. Endothelial cells in the thrombus segment examined using terminal deoxynucleotidyl...