A5100341946- Pomegranate: compositions and health benefits
- Epigenetics and DNA Methylation
- Fatty Acid Research and Health
- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Diet, Metabolism, and Disease
- Peroxisome Proliferator-Activated Receptors
- Adipokines, Inflammation, and Metabolic Diseases
- Lipid metabolism and biosynthesis
- Cynara cardunculus studies
- Natural product bioactivities and synthesis
- Neuroinflammation and Neurodegeneration Mechanisms
- Liver Disease Diagnosis and Treatment
- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Antioxidant Activity and Oxidative Stress
- Bioactive Compounds in Plants
- Metabolism, Diabetes, and Cancer
- Asthma and respiratory diseases
- Vestibular and auditory disorders
- Traditional Chinese Medicine Analysis
- Sesame and Sesamin Research
- Nuclear Receptors and Signaling
- Nitric Oxide and Endothelin Effects
- Sleep and Work-Related Fatigue
Qingdao University
2021-2025
Hainan Medical University
2020-2025
Nanjing University
2024
Chongqing Medical University
2024
Children's Hospital of Chongqing Medical University
2024
Capital Institute of Pediatrics
2023
Shanghai Jiao Tong University
2022
Yangzhou University
2022
Xi'an Jiaotong University
2006-2021
Xian Central Hospital
2021
The tripeptide glutathione (GSH) is used by cells to detoxify hydroperoxides, produced during oxidative stress, and consumed in the process. Previous studies have indicated that can be protected against stress extracellular GSH through its degradation catalyzed exoenzyme gamma-glutamyl transpeptidase (gamma GT) de novo synthesis within cytosol. We hypothesized gamma GT would increased as part of adaptation stress. examined whether could increase activity, protein, mRNA a lung epithelial cell...
The integrity of skin tissue structure and function plays an important role in maintaining rejuvenation. Ultraviolet (UV) radiation is the main environmental factor that causes aging through photodamage tissue. Cryptotanshinone (CTS), active ingredient mianly derived from Salvia plants Lamiaceae, has many pharmacological effects, such as anti-inflammatory, antioxidant, anti-tumor effects. In this study, we showed CTS could ameliorate induced by UV epidermal keratinocytes (HaCaT) dermal...
To investigate the effect of regional citrate anticoagulation (RCA) on clinical outcome, renal function, and bleeding complications in patients with acute kidney injury (AKI) undergoing continuous replacement therapy (CRRT). This retrospective study reviewed medical records 180 treated at Second Affiliated Hospital Hainan Medical University from January 2020 to 2023. Patients were divided into two groups based strategy: 85 who received systemic heparin (control group, CG) 95 RCA (research...
Dual-energy computed tomography (DECT) enhances tissue imaging characterization. However, no studies have evaluated the diagnostic accuracy of electron density (ED) for simultaneously displaying lumbar disc and calcification. This retrospective study aimed to investigate ability ED visualize disease as compared with standard (SC) virtual noncalcium (VNCa) in order provide a viable alternative disease. From October 2023 February 2024, we retrospectively analyzed data from 53 patients who...
The study investigated the effect of pomegranates ellagic acid (PEA) on blood cholesterol and its effects LXR/RXR/PPAR-ABCA1 nuclear receptors-signaling pathways metabolism molecular level in hamsters. In this experiment, hamsters were randomly divided into two groups: first group (NG, n = 9) was always fed normal diet, whereas other (HFG, 45) a high fat diet during 4 weeks then for last weeks. HFG, which five groups (n weeks, three treated with PEA at 44 mg per kg bw, 88 bw 177 one...
Scope Apple pomace polysaccharides (APP), a free radical scavenger, is one of the major compounds derived from apple pomace. However, whether APP has beneficial effects on metabolic disorders still unknown. Methods and results In present study, water‐soluble was isolated locally abundant “Qinguan” chemically characterized. Then, orally administrated to high‐fat diet (HFD)‐induced obese mice. We found that significantly reduced HFD‐induced body weight gain ameliorated hepatic oxidative...
Mild hypothermia (MH) and edaravone (EDA) exert neuroprotective effects against cerebral ischemia/reperfusion (I/R) injury through activation of the nuclear factor erythroid 2‑related 2 (Nrf2) pathway. However, whether MH EDA synergistic I/R remains unknown. The aim present study was to investigate mechanism action in combination with injury. A rat model constructed by middle artery occlusion (MCAO) followed reperfusion, mice were treated MH, or inhibitor Nrf2 signaling pathway brusatol...
Punicalagin exerts neuroprotective activity by improving AMP-activated kinase (AMPK) and mitochondrial Krebs cycle. AMPK cycle metabolites regulate 5-hydroxymethylcytosine (5hmC) via acting on ten-eleven translocation (TET) enzymes. Therefore, we hypothesized that punicalagin inhibits diabetes-related neuronal apoptosis upregulating 5hmC in the diabetic mouse brain. C57BL/6J mice aged 8 weeks were randomly separated into five groups (n = 10), normal control (NC), diabetes mellitus (DM),...
This study was aimed to compare the relative activities of purified pomegranate peels polyphenols (PPPs) with some other plant including punicalagin, ellagic acid, gallic phlorizin, and epigallocatechin gallate (EGCG) on lipid metabolism regulation, cholesterol efflux mechanisms PPPs punicalagin were also investigated. In this paper, a convenient accurate in vitro HL7702 steatosis hepatic cell model applied evaluate lipid-lowering effects tested polyphenols. The results showed that possessed...
Objective: To investigate the brain functional organization induced by sleep deprivation (SD) using connectivity density (FCD) analysis. Methods: Twenty healthy subjects (12 female, 8 male; mean age, 20.6 ± 1.9 years) participated a 24 h design. All underwent MRI scan and attention network test twice, once during rested wakefulness (RW) status, other was after acute SD. FCD divided into shortFCD longFCD. Receiver operating characteristic (ROC) curve used to evaluate discriminating ability of...
Gold nanoparticles (AuNPs) have been proposed for many applications in medicine and bioanalysis. For use all these applications, maintaining the stability of AuNPs solution by suppressing aggregation is paramount. Herein, effects amino acids were investigated stabilizing rationally designed peptide scaffolds. Compared to other tested acids, phosphotyrosine (pY) significantly stabilized AuNPs. Our results indicated that pY modified presented a high level various solutions, had good...
Ellagic acid (EA) improves mitochondrial dysfunction and protects diabetic hearts. The tricarboxylic (TCA) cycle regulates DNA 5-hydroxymethylcytosine (5hmC) levels by affecting activity of 10-11 translocation enzymes (TETs). Therefore, we hypothesized that EA prevents cardiac modulating 5hmC levels. C57BL/6J mice were fed a high-fat diet to induce diabetes treated with (100 mg kg-1 day-1) for 8 weeks. Serum concentrations glucose, insulin, triglyceride aspartate transaminase creatine kinase...
To identify whether the amplitude of low-frequency fluctuations (ALFF) analysis has potential to serve as a biological marker detect alcohol-induced spontaneous brain activities and distinguish patients with alcohol dependence from healthy subjects.We utilized ALFF report on in 29 (9 female, 20 male) relative status-matched subjects (11 18 male). Receiver operating characteristic curve was used test ability discriminating subjects. Pearson correlation evaluate relationships between signal...
Cervical discogenic pain (CDP) is a clinically common syndrome caused by cervical disk degeneration. A large number of studies have reported that CDP results in brain functional impairments. However, the detailed dynamic abnormalities are still unclear. In this study, using resting-state magnetic resonance imaging, we explored neural basis with 40 patients and age-, gender-matched healthy controls to delineate changes voxel-level static amplitude low frequency fluctuations (ALFF). We found...