A5101577696- Renal and related cancers
- RNA modifications and cancer
- Dye analysis and toxicity
- Chronic Myeloid Leukemia Treatments
- Biochemical Analysis and Sensing Techniques
- Acute Myeloid Leukemia Research
- Molecular Sensors and Ion Detection
- Cancer-related molecular mechanisms research
- S100 Proteins and Annexins
- Cancer-related gene regulation
- Peer-to-Peer Network Technologies
- Genetic factors in colorectal cancer
- Epigenetics and DNA Methylation
- Peroxisome Proliferator-Activated Receptors
- Genetic and Kidney Cyst Diseases
- interferon and immune responses
- Immune Response and Inflammation
- RNA Research and Splicing
- Cancer Genomics and Diagnostics
- Opportunistic and Delay-Tolerant Networks
- Gestational Diabetes Research and Management
- Pluripotent Stem Cells Research
- Plant-based Medicinal Research
- Cancer-related Molecular Pathways
- Immune cells in cancer
XinHua Hospital
2025
Shanghai Jiao Tong University
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Sun Yat-sen University
2021-2023
Sun Yat-sen University Cancer Center
2021-2023
Peking Union Medical College Hospital
2023
State Key Laboratory of Oncology in South China
2022
Changzhou No.2 People's Hospital
2022
City University of Hong Kong
2021
Anhui Medical University
2021
Abstract Dysregulation of the cell cycle machinery leads to genomic instability and is a hallmark cancer associated with chemoresistance poor prognosis in colorectal (CRC). Identifying targeting aberrant expected improve current therapies for CRC patients. Here,upregulated polo‐like kinase 1 (PLK1) signaling, accompanied by deregulation cycle‐related pathways identified. It shown that PLK1 signaling correlates recurrence Genetic pharmacological blockade significantly increases sensitivity...
Aneuploidy, a deviation of the chromosome number from euploidy, is one hallmarks cancer. High levels aneuploidy are generally correlated with metastasis and poor prognosis in cancer patients. However, causality remains to be explored. Here we demonstrate that teratomas derived aneuploid murine embryonic stem cells (ESCs), but not isogenic diploid ESCs, disseminated multiple organs, for which no additional copy variations were required. Notably, driver gene mutations identified any...
Prevalent copy number alteration is the most prominent genetic characteristic associated with ovarian cancer (OV) development, but its role in immune evasion has not been fully elucidated. In this study, we identified RAD21, a key component of cohesin complex, as frequently amplified oncogene that could modulate response OV. Through interrogating RAD21-regulated transcriptional program, found RAD21 directly interacts YAP/TEAD4 corepressors and recruits NuRD complex to suppress interferon...
Abstract Background Enhancer of zeste homolog 2 (EZH2), the key catalytic subunit polycomb repressive complex (PRC2), is overexpressed and plays an oncogenic role in various cancers through catalysis-dependent or catalysis-independent pathways. However, related mechanisms contributing to ovarian cancer (OC) are not well understood. Methods The levels EZH2 H3K27me3 were evaluated 105 OC patients by immunohistochemistry (IHC) staining, these stratified based on levels. Canonical noncanonical...
Abstract Novel strategies to treat late-stage nasopharyngeal carcinoma that often develop resistance chemotherapy remains an unmet clinical demand. In this study, we identify the multi-kinase inhibitor pacritinib as capable of resensitizing response paclitaxel in acquired model. Transcriptome analysis paclitaxel-sensitive and -resistant cell lines, well chemorefractory samples, identified S100A9 top candidate gene suppressed by whose overexpression was significantly associated with poor...
Three pyoverdines, Pf-A, Pf-B, and Pf-C, were purified with copper-chelate Sepharose Sephadex G-15 columns from Pseudomonas fluorescens 2-79, the yields (per 100 ml of culture supernatant) 2.8, 21.6, 3.2 mg, respectively. The absorption fluorescence spectra these pyoverdines strongly pH dependent. Characteristic changes in maximal absorbance wavelengths observed when Fe(sup3+) or Cu(sup2+) was added. addition shifted pyoverdine Pf-B spectrum so that it exhibited a single peak at 410 nm but...
Abstract The absorption spectrum of Sudan red III (SR) in oil solutions and a series O/W microemulsion with surfactant sodium dodecyl sulfate (SDS) has been determined by the UV-Vis spectrophotometer. We found that an association interaction existed between stain SR anionic SDS water/mixed oil/SDS microemulsions. By measuring absorbance microemulsions which different R values using appropriate models to analyze experimental data, we obtain constants SDS, thermodynamics functions...
The absorption spectrum of Sudan Red III (SR) in aqueous solution and a series alcohol solutions containing sodium dodecyl sulfate (SDS) surfactant was determined by UV-Vis spectrophotometry. After establishing appropriate association models to analyze the experimental data, constants K m SR SDS various were determined. All greater than those water. ethanol had largest constant, indicating that addition small amount enhanced between SDS. Association thermodynamics function Δ r G values also...
Sepsis is an organ dysfunction caused by the dysregulated inflammatory response to infection. Lipopolysaccharide-binding protein (LBP) binds lipopolysaccharide (LPS) and modulates response. A rare systematic study has been reported detect effect of LBP gene during LPS-induced sepsis. Herein, we explored RNA sequencing technology profile transcriptomic changes in liver tissue between LBP-deficient rats WT at multiple time points after LPS administration. We proceeded search differentially...
Peer-to-peer (P2P) systems, which are realized as overlays on top of the underlying Internet routing architecture, contribute a significant portion today's traffic. But P2P systems has no access to network, it either measure path performance itself or build its overlay topology agnostic underlay, often leads traffic management challenges for Service Providers (ISPs) and poor QoS users. To overcome these problems, we design scheme, clusters peers based information physical network they belong...