A5103143474- Chronic Myeloid Leukemia Treatments
- Acute Myeloid Leukemia Research
- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Inflammatory Biomarkers in Disease Prognosis
- Multiple Myeloma Research and Treatments
- Inflammation biomarkers and pathways
- Histone Deacetylase Inhibitors Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Eosinophilic Disorders and Syndromes
- CNS Lymphoma Diagnosis and Treatment
- Protein Degradation and Inhibitors
- Acute Lymphoblastic Leukemia research
- Tendon Structure and Treatment
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Acupuncture Treatment Research Studies
- Digital Imaging for Blood Diseases
- Quinazolinone synthesis and applications
- Angiogenesis and VEGF in Cancer
- Periodontal Regeneration and Treatments
- Axon Guidance and Neuronal Signaling
- Acute Ischemic Stroke Management
- Epigenetics and DNA Methylation
- interferon and immune responses
- Cardiac Health and Mental Health
The First People’s Hospital of Lianyungang
2009-2025
Nanjing Medical University
2021-2025
Xuzhou Medical College
2019-2025
Kangda College of Nanjing Medical University
2023-2024
Jinzhou Medical University
2024
Committee on Publication Ethics
2022
Weatherford College
2022
Soochow University
2022
First Affiliated Hospital of Soochow University
2022
Zhongda Hospital Southeast University
2019-2021
To explore the value of cytogenetic risk stratification combined with minimal residual disease (MRD) status in predicting therapeutic efficacy and prognosis for multiple myeloma (MM). From January 2017 to December 2023, 73 cases newly diagnosed MM were recruited. Cytogenetic risks stratified according results fluorescence situ hybridization (FISH); MRD clinical data analyzed. The progression-free survival (PFS) overall (OS), their influencing factors evaluated. During median follow-up period...
Objective To investigate the prognostic value of lactate dehydrogenase (LDH), serum albumin (ALB) and dehydrogenase/albumin ratio (LAR) in diffuse large B-cell lymphoma (DLBCL) before primary treatment.
Abstract: Chronic myeloid leukemia (CML) and Non-Hodgkin Lymphoma (NHL) are two different origins of hematological malignancies, which rarely occur at the same time. Moreover, NHL secondary to CML is common in T cell lymphoma, while B origin rare. Since 1999, only 22 cases with lymphoma have been reported, 4 diffuse large B-cell (DLBCL). The lesions DLBCL were lymph node, liver, jejunum, soft palate. To our knowledge, it has no report for primary gastric (PG-DLBCL) occurring CML. Here we...
Purpose:The early BCR-ABL1 reduction had the prognostic impact of chronic-phase chronic myeloid leukemia (CML-CP) patients.This study was to find a more precise prognosis index at 3 months in patients with newly diagnosed CML-CP, especially for IS >10%.Methods: We retrospectively analyzed data 79 CML-CP from October 2013 April 2017.All took imatinib regularly and continuously monitored transcript level baseline 3, 6, 9, 12, 18 after starting treatment.Results: Among 44(55.7%)patients...
Roundabout guidance receptor proteins are crucial components of the SLIT/ROBO signaling pathway. This pathway is important for nervous system and in embryonic development. Recently, increasing evidence has shown that roundabout also participate tumorigenesis. Here, by analyzing transcriptome data from TCGA GEO databases, we found ROBO3 highly expressed non-M3 acute myeloid leukemia. High expression was associated with increased age at diagnosis poorer risk classification (both P < 0.01)....
To analyze the efficacy and safety of flumatinib, a second-generation tyrosine kinase inhibitor (TKI) independently developed in China, patients with chronic myelogenous leukemia phase (CML-CP) who falied first-line second-line treatment.
To investigate the clinical efficacy and safety of ixazomib-containing regimens in treatment patients with multiple myeloma (MM).
To evaluate the incidence rate of IDH1 in acute myeloid leukemia and analyze its effect on clinical characteristics prognosis.Mononuclear cells bone marrow samples were collected from 192 adult patients with newly diagnosed AML. Polymerase chain reaction (PCR) direct sequencing used to amplify exon 4 gene, gene was mutations, at same time, detection NPM1, FLT3-TKD, FLT3-ITD, C-KIT, CEPBA, TET2 JAK2V617F MLL mutations carried out, follow-up determine therapeutic efficacy outcomes patients....
To investigate the effects of interferon-α2b combined with thalidomid(THD) on proliferation and apoptosis HEL cells, expression JAK2V617F-mutated gene.The cell survival rates were assayed by CCK-8 after cells treated interferon-α2b, thalidomid for 24, 48 72 hours, while JAK2V617F mutation gene detected flow cytometry fluorescence quantitative PCR respectively treatmemt hours.IFN-α2b THD could more obviously inhibit than IFN-α2b or alone 24 differences between groups statistically...
To analyze the related factors affecting nosopoiesis of childhood acute leukemia from perspective indoor environmental exposure, behavior and lifestyle.The clinical data 64 children with were retrospectively analyzed, 50 healthy selected as control group during same period. The basic children, environment, lifestyle parents in 2 groups recorded. Univariate multivariate logistic regression analysis used to incidence leukemia, OR (95%CI) value was calculated.The unvariate showed that daily...
To investigate the clinical characteristics of RAS gene mutations in patients with acute myeloid leukemia (AML).43 were detected using next-generation sequencing (NGS) 180 AML who first diagnosed between May 2011 and February 2021. The molecular features their effects on efficacy survival retrospectively analyzed.Among patients, proportion pathway-related genes NRAS (14.4%), KRAS (2.2%), FLT3-ITD (13.8%), PTPN11 (7.7%), KIT (5.0%), FLT3-TKD (3.8%) CBL (2.7%). Seventy-three (40.6%) had...
Percutaneous coronary intervention (PCI) is an effective treatment for heart disease (CHD). With the merits of small trauma and high success rate, PCI can promote fast recovery CHD patients greatly improve their prognosis quality life. However, because does not eliminate pathogenic factors that lead to atherosclerosis, major adverse cardiovascular events (MACEs) often occur after PCI. These have become one principal affecting long-term outcome In China, increasing attention paid use...
To investigate the carrier rate and clinical characteristics of epigenetic modification gene mutations (EMMs) among patients with acute myeloid leukemia (AML).One hundred seventy two who were initially diagnosed AML at First People's Hospital Lianyungang from May 2011 to February 2021 selected as study subjects. Next-generation sequencing was carried out detect variants 42 genes these patients. Clinical molecular EMMs effect demethylation drugs (HMAs) on their survival analyzed.Among 172...
Objective To investigate the clinical significance of flow cytometry (FCM) assay in following up minimal residual disease (MRD) used for predicting relapse and guiding chemotherapy. Methods The data 43 acute leukemia patients diagnosed by MIC were collected our hospital from 2005 July to 2008 June.Bone marrow aspirates with newly after induction therapy during constimulation therapy. cells associated immunophenotype investigated using FCM, as immunologic target MRD. Results MRD detected...
To evaluate the clinical value of combined detection BCL-2 and PD-L1 in predicting prognosis newly diagnosed patients with acute leukemia (AL).A total 100 cases AL our hospital from Jan. 2013 to Sep. 2016 were enrolled study. The mRNA expression peripheral blood was detected by RT-PCR, followed up. According follow-up results, these divided into complete remission group no group, statistical analysis different indexes performed.Compared healthy control positive rates bone marrow specimens...
Chronic myeloid leukemia (CML) is a malignant myeloproliferative neoplasm that occurs in pluripotent hematopoietic stem cells. Pathogenesis of CML slow, and leukocytosis splenomegaly are main clinical features patients with CML. The introduction tyrosine kinase inhibitor (TKI) imatinib mesylate (IM) has changed the natural progression significantly improved survival patients. However, prolonged application IM, IM resistance become major challenge treatment Many studies currently working to...