A5100347034- Liver Disease and Transplantation
- Hepatitis C virus research
- Inflammatory Biomarkers in Disease Prognosis
- Sperm and Testicular Function
- Reproductive Biology and Fertility
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Pharmaceutical Economics and Policy
- Helicobacter pylori-related gastroenterology studies
- Molecular Biology Techniques and Applications
- Healthcare Systems and Reforms
- RNA modifications and cancer
- Hepatitis Viruses Studies and Epidemiology
- Cancer Immunotherapy and Biomarkers
- RNA Research and Splicing
- Pharmacology and Obesity Treatment
- Venous Thromboembolism Diagnosis and Management
- Health Systems, Economic Evaluations, Quality of Life
- CAR-T cell therapy research
- Hormonal and reproductive studies
- Acute Lymphoblastic Leukemia research
- Thyroid Cancer Diagnosis and Treatment
- Economic and Financial Impacts of Cancer
- Phosphodiesterase function and regulation
- Renin-Angiotensin System Studies
- SARS-CoV-2 and COVID-19 Research
Suzhou Municipal Hospital
2019-2025
Nanjing Medical University
2016-2025
The First People’s Hospital of Lianyungang
2023
Kangda College of Nanjing Medical University
2023
Xuzhou Medical College
2023
Jiangsu Province Hospital
2014-2022
Changzhou No.2 People's Hospital
2021
Jiangsu Cancer Hospital
2021
Nanjing Maternity and Child Health Care Hospital
2019
Jiangsu Provincial Hospital of Traditional Chinese Medicine
2016
Scientific Report10 January 2017free access Source DataTransparent process The E3 ubiquitin ligase RNF114 and TAB1 degradation are required for maternal-to-zygotic transition Ye Yang State Key Laboratory of Reproductive Medicine, Department Histology Embryology, Nanjing Medical University, Nanjing, China Reproduction, Obstetrics Gynecology Hospital Affiliated to Search more papers by this author Cheng Zhou Ying Wang Weixiao Liu Stem Cell Biology, Institute Zoology, the Chinese Academy...
Systemic inflammation is closely correlated with the progression of cancer. Inflammation-related indicators has been recognized as outcome predictors in triple-negative breast cancer (TNBC). Our study aimed to investigate predictive value several inflammation-related TNBC patients underwent chemotherapy (NAC). 100 were enrolled study. Levels interleukin-6 (IL-6) detected by enzyme-linked immunosorbent assays (ELISAs). Platelet-to-lymphocyte ratio (PLR) and immune inflammatory index (SII)...
DDX3X is a highly conserved DEAD-box RNA helicase that participates in transcription, splicing, and mRNA transport, translation, nucleo-cytoplasmic transport. It expressed metaphase II (MII) oocytes the predominant DDX3 variant ovary embryo. However, whether it important mouse early embryo development remains unknown. In this study, we investigated function of embryogenesis by cytoplasmic microinjection with its siRNA zygotes or single blastomeres 2-cell embryos. Our results showed knockdown...
Abstract Cardio-renal fibrosis plays key roles in heart failure and chronic kidney disease. We sought to determine the effects of renal denervation (RDN) on cardiac rats with isoproterenol induced cardiomyopathy. Sixty male Sprague Dawley were randomly assigned Control (n = 10) (ISO)-induced cardiomyopathy group 50). At week 5, 31 survival ISO-induced randomized RDN 15) Sham 16). Compared group, ejection fraction was decreased, diastolic interventricular septal thickness left atrial...
Objectives: With the increasing incidence of cancer, poor access to affordable anticancer medicines has been a serious public health problem in China. To help address this issue, we assessed availability, price and affordability pharmacotherapy for cancer hospitals Jiangsu Province, Methods: In 2012 2016, medicine availability information capital five other cities was collected. A total six care hospitals, 26 tertiary general 28 secondary were sampled, using an adaptation World Health...
Early diagnosis and prognosis evaluation are of great significance to hepatitis E virus (HEV)-related acute liver failure (HEV-ALF) patients. We collected serum samples from 200 health controls (HCs), patients with (AHE), HEV-ALF evaluate exosome-derived carbamoyl phosphate synthase 1 (CPS1) levels determine its diagnostic prognostic value. The CPS1 in the group were significantly higher than those AHE HCs groups. AUC predict occurrence was 0.850 (0.811-0.883). Both logistical regression...
The azoospermia factor c (AZFc) region in the long arm of human Y chromosome is characterized by massive palindromes. It harbors eight multi-copy gene families that are expressed exclusively or predominantly testis. To assess systematically role AZFc and these spermatogenesis, we conducted a comprehensive molecular analysis (including haplogrouping, deletion typing copy quantification) 654 idiopathic infertile men 781 healthy controls Han Chinese population. b2/b3 partial both deletion-only...
Early diagnosis for the diabetes complications is clinically demanding with great significancy. Regarding complexity of complications, we applied a multi-label classification (MLC) model to predict four diabetic simultaneously using data in modern electronic health records (EHRs), and leveraged correlations between further improve prediction accuracy.We obtained demographic characteristics laboratory from EHRs patients admitted Changzhou No. 2 People's Hospital, affiliated hospital Nanjing...
Objective. This study was aimed at investigating the diagnostic value of neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte (PLR), C-reactive protein-to-albumin (CAR), and systemic inflammatory response index (SIRI) for catheter-related bloodstream infection (CRBSI) in patients undergoing haemodialysis. Methods. A total 296 haemodialysis with vascular access were selected divided into infected (58 patients) uninfected (238 groups. Their aetiological general characteristics...
AIMTo evaluate diagnostic yields of capsule endoscopy (CE) and/or single-balloon enteroscopy (SBE) in patients with suspected small bowel diseases. METHODSWe retrospectively analyzed 700 diseases from September 2010 to March 2016.CE, SBE, or SBE prior CE was performed 401, 353, and 47 patients, respectively.Data clinical records were collected for analysis.Indications, procedure times, yields, complications summarized evaluated.
Colon carcinoma is one of the most common cancers worldwide. Epidemiological studies have revealed that colon cancer third leading cause cancer‑related deaths, which due to increased incidence and mortality rates. However, treatment strategies for remain unsatisfactory patients, especially those with advanced or recurrent cancer. Dysregulated microRNAs (miRNAs) are considered influence tumor development metastasis. molecular mechanism through miRNAs affect progression not yet completely...
To evaluate the prognostic ability of model for end-stage liver disease (MELD) to serum sodium (SNa) ratio (MESO) index and compare predictive accuracy MESO with MELD score modified Child-Turcotte-Pugh (CTP) short-term survival in cirrhotic patients.A total 256 patients cirrhosis were retrospectively evaluated. The index, CTP compared by area under receiver-operator characteristic curve (AUC).Using 1-month 3-month mortality as end-point, overall, significantly better than predicting risk at...
Development of biomarkers for predicting the occurrence hepatitis E virus related-acute liver failure (HEV-ALF) is conducive to prevention and early intervention. Serum samples from 250 HEV-ALF patients, patients with acute (AHE) health controls (HCs) were collected. We assessed predictive ability extracellular vesicle (EV)-derived argininosuccinate synthase 1 (ASS1) levels occurrence. EVs successfully isolated. EV-derived ASS1 in significantly higher than those AHE HCs. In positively...
Background: Here, we establish a prognostic signature based on glycosyltransferase-related genes (GTRGs) for head and neck squamous cell carcinoma (HNSCC) patients. Methods: The of GTRGs was constructed via univariate multivariate Cox analyses after obtaining the expression patterns from TCGA. A nomogram clinical parameters established to predict survival each HNSCC patient. Potential mechanisms were explored through gene set enrichment analysis (GSEA) immune infiltration, checkpoints,...
<title>Abstract</title> <bold>Objective: </bold>To explore a better tracing of central lymph nodes in papillary thyroid carcinoma patients by comparing the differences number and staining nano-carbon extravasation between preoperative ultrasound- guided injection intraoperative nano-carbon. <bold>Methods: </bold>Totally 302 were randomly divided into group an group. The each sub-area region recorded analyzed, including linea alba cervical nodes, Delphian pretracheal paratracheal nodes....
Introduction Central nervous system leukemia (CNSL) is the most common extramedullary relapse site in patients with Philadelphia chromosome-positive (Ph-positive) acute lymphoblastic (ALL), a poor prognosis and high rate. Methods We characterized clinical data of 21 Ph-positive B-ALL to analyze efficacy safety ponatinib for central relapsed ALL retrospectively. Results There were 11 males 10 females cohort, their median age was 45 (9-58) years old. The total CR (complete remission) rate...
Objective To investigate the prognostic value of lactate dehydrogenase (LDH), serum albumin (ALB) and dehydrogenase/albumin ratio (LAR) in diffuse large B-cell lymphoma (DLBCL) before primary treatment.
Cervical cancer is one of the leading causes mortality in women, which seriously threatens health women worldwide. Platelet (PLT)-related parameters, including PLT count, mean platelet volume (MPV), plateletcrit (PCT), and distribution width (PDW), are correlated with tumor prognosis.In total, 110 patients cervical carcinoma were recruited this study. The divided into 2 groups according to receiver operating characteristic analysis cutoff values PLT, MPV, PCT, or PDW. post-/preradiotherapy...
Abstract The Y chromosome has high genetic variability with low rates of parallel and back mutations, which make up the most informative haplotyping system. To examine whether haplogroups (Y-hgs) could modify effects autosomal variants on non-obstructive azoospermia (NOA), based our previous genome-wide association study (GWAS), we conducted a interaction analysis in GWAS subjects. Logistic regression demonstrated protective effect Y-hg O3e * NOA. Then, explored potential between variants....
Objective: We aimed to investigate serum exosomal adenosylhomocysteinase (AHCY) expression in hepatitis B-induced liver cirrhosis (HBV-LC) patients and determine the prognostic value of AHCY. Methods: collected samples from 100 with chronic B (CHB) 114 HBV-LC test AHCY using ELISA. Results: Compared CHB Grade A groups, level was significantly higher group [376.62 (291.50-448.02) vs. 248.12 (189.28-324.63), P > 0.001] C [408.70 (365.63-465.76) 279.76 (215.16-336.07), 0.001], respectively....