Long noncoding RNAs (lncRNAs) have been confirmed to be potential prognostic markers in a variety of cancers and interact with microRNAs (miRNAs) as competing endogenous (ceRNAs) regulate target gene expression. However, the role lncRNA‑mediated ceRNAs breast cancer (BC) remains unclear. In present study, ceRNA network was generated explore their BC. The expression profiles mRNAs, miRNAs lncRNAs 1,109 BC tissues 113 normal were obtained from Cancer Genome Atlas database (TCGA). A total 3,198...

Triglyceride-glucose (TyG) related indices, which serve as simple markers for insulin resistance, have been closely linked to metabolic dysfunction-associated steatotic liver disease (MASLD), cardiovascular (CVD), and mortality. However, the prognostic utility of TyG-related indices in predicting risk CVD mortality among patients with MASLD remains unclear. Data 97,331 patients, a median age 58.0 years free at baseline, were obtained from UK Biobank. The TyG index, along its combination...

The Life's Essential 8 (LE8) proposed by the American Heart Association for assessing cardiovascular health (CVH) has been demonstrated to be associated with disease, but rarely includes heart failure (HF), and role of psychological factors not considered. We aimed prospectively investigate independent, joint, interactive associations LE8 depressive symptoms HF incidence. A total 336,939 participants recruited from UK Biobank without HF, coronary stroke were included in cohort study. score...

The widespread use of pesticides performs a vital role in safeguarding crop yields and quality, providing the opportunity for multiple to co-exist, which poses significant potential risk human health. To assess toxic effects caused by exposures individual (chlorpyrifos, carbofuran acetamiprid), binary combinations ternary combinations, combined exposure models were developed using HepG2 cells types pesticide mixtures assessed concentration addition (CA), independent action (IA) combination...

Aim: To establish and validate a nomogram for the estimation of overall survival patients with uterine leiomyosarcoma (uLMS). Methods: Information on diagnosed as uLMS was retrospectively retrieved from Surveillance, Epidemiology, End Results database. The were randomly assigned into training validation cohorts. Univariate multivariate analyses used to determine independent prognostic factors building predicting survival. predictive accuracy evaluated based concordance indices calibration...

Background Breast cancer (BC), especially metastatic BC, is one of the most lethal diseases in women. CA 125 and 15-3 are commonly used indicators for diagnosis prognosis BC. Some serological indicators, such as lactate dehydrogenase (LDH) C-reactive protein (CRP), can also be to assess progression Methods Univariate Cox regression analysis LASSO were performed identify prognostic factors build models. We distributed patients into 2 groups based on median risk score, analyzed by Kaplan–Meier...

Due to the high prevalence of multimorbidity and realistic health service demands for fall prevention, there is growing interest in association between falls. Our study aimed identify patterns among Chinese older adults explore Data from 4,579 community-dwelling was included this analysis. Information regarding falls 10 chronic conditions collected. An exploratory factor analysis performed determine patterns. Regression models were fitted associations individual disease or with Among...

Abstract Bladder cancer is one of the most common cancers worldwide. The immune response and cell infiltration play crucial roles in tumour progression. Immunotherapy has delivered breakthrough achievements past decade bladder cancer. Differentially expressed genes immune-related (DEIRGs) were identified by using edgeR package. Gene ontology annotation Kyoto Encyclopedia Genes Genomes (KEGG) pathway analyses performed for functional enrichment analysis DEIRGs. Survival-associated IRGs...

In this paper, we design a framework to combine deep neural network (DNN) and the traditional separate inversion workflow together improve joint result iteratively for multi-physics data. Different from conventional end-to-end networks, our proposed learning enhanced (DLE) takes separately inverted models, instead of data, as inputs DNN, constructing structure similarity constraints during process where no specific relationship between different property values is assumed in advance....

Cervical carcinoma is the leading cause of cancer mortality in women. C-reactive protein (CRP), albumin (ALB), globulin (GLB), lactate dehydrogenase (LDH), and albumin-to-globulin ratio (AGR) are indicators systemic inflammation response correlated with tumor outcomes.This study recruited 110 patients cervical cancer. The were divided into 2 groups according to pretreatment median values CRP, ALB, GLB, LDH, AGR. post/preradiotherapy or post/pretreatment ratios defined as rates AGR...

Hepatocellular carcinoma (HCC) is one of the most prevalent neoplasms worldwide, particularly in China. Immune-related genes (IRGs) and immune infiltrating lymphocytes play specific roles tumor growth. Considering how important immunotherapy has become for HCC treatment past decade, our objective was to establish a prognostic model by screening survival-related IRGs patients with HCC. Using edgeR, we identified differentially expressed (DEIRGs), DEmiRNAs, DElncRNAs. Functional enrichment...

Obesity, especially central obesity, is a strong risk factor for developing type 2 diabetes (T2D). However, the mechanism underlying progression from obesity to T2D remains unknown. Therefore, we analyzed gut microbial profiles of obese individuals with or without Chinese population. Here reported both compositional and gene functional alterations during T2D. Several opportunistic pathogens were enriched in patients. We also characterized thousands genes involved sugar amino acid metabolism...

Background The increasing prevalence of nonalcoholic fatty liver disease (NAFLD) in China presents a significant public health concern. Traditional ultrasound, commonly used for screening, often lacks the ability to accurately quantify steatosis, leading insufficient follow-up patients with moderate-to-severe steatosis. Transient elastography (TE) provides more quantitative diagnosis steatosis and fibrosis, closely aligning biopsy results. Moreover, machine learning (ML) technology holds...

Long non-coding RNAs (lncRNAs) can act as competing endogenous (ceRNAs), interacting with microRNAs (miRNAs) and playing an important role in tumor progression. However, the of lncRNA-mediated ceRNAs glioma remains largely unknown. The present study aimed to identify novel lncRNAs their associated function glioma. RNA sequencing corresponding clinical data from patients were obtained Cancer Genome Atlas. A total 598 tissues 5 normal brain analyzed study. differentially expressed (DE)...

Abstract Cervical cancer is one of the most common tumors in women. Neutrophils (NEs) and platelets (PLTs) are components cells circulating blood. NEs white blood (WBCs), accounting for vast majority WBCs, recognized as indicators inflammation. PLTs associated with thrombosis Both them play an important role tumor growth metastasis. According to pre-radiotherapy PLT NE media levels, we divided patients into three groups: both high levels group, single level group low group. By using COX...

Cervical cancer is one of the leading causes mortality in women, which seriously threatens health women worldwide. Platelet (PLT)-related parameters, including PLT count, mean platelet volume (MPV), plateletcrit (PCT), and distribution width (PDW), are correlated with tumor prognosis.In total, 110 patients cervical carcinoma were recruited this study. The divided into 2 groups according to receiver operating characteristic analysis cutoff values PLT, MPV, PCT, or PDW. post-/preradiotherapy...

Aim: Cervical cancer is one of the leading causes mortality in women. Peripheral white blood cell parameters such as neutrophil (NE), eosinophil (EO), basophil (BA), well lymphocyte (LY) and monocyte (MO), are correlated with tumor outcomes. Methods: In total, 110 cervical squamous carcinoma patients were recruited this study. The potential prognostic factors evaluated by univariate multivariate survival analysis. Results: Cox regression analysis model indicated that higher pretreatment EO...

Lung cancer has the highest incidence and mortality rates of all cancers in China. Immune‑related genes immune infiltrating lymphocytes are involved tumor growth, past decade, immunotherapy become increasingly important treatment lung cancer. Using edgeR package, differentially expressed immune‑related (DEIRGs) were identified patients with adenocarcinoma (LUAD). Functional enrichment analysis DEIRGs was performed using Gene Ontology annotation Kyoto Encyclopedia Genes Genomes (KEGG) pathway...

Abstract Breast cancer (BC) is currently one of the deadliest tumors worldwide. Cancer stem cells (CSCs) are a small group tumor with self-renewal and differentiation abilities high treatment resistance. One reasons for failures inability to completely eliminate cells. By using edgeR package, we identified stemness-related differentially expressed genes in GSE69280. Via Lasso-penalized Cox regression analysis univariate analysis, survival were screened out construct prognostic model....

Fungal contamination of crops is widespread and fungicides are often used to prevent fungal growth mycotoxin contamination, but this can lead co-contamination ecological environments such as fields, aquatic areas with fungicide residues; which negatively affect the function stability ecosystems. Meanwhile, it also jeopardize food safety pose a threat human health. Therefore, important investigate health implications combined presence mycotoxins in environment. To address issue, based on...

Personality has an impact on the health-related quality of life (HRQoL) older adults. However, relationship and mechanisms 2 variables are controversial, few studies have been conducted

To examine the association and modifiable risk factors between grip strength (GS) Parkinson's disease (PD) incidence considering genetic factors, a total of 411,648 individuals without PD at baseline from UK Biobank were included. GS was measured by hydraulic dynamometer. The polygenic score assessed predisposition. Multivariable Cox regression models performed. During median follow-up 12.3 years, 2409 developed PD. Compared with those high GS, low-GS had 58.5% increased (42.7%–76.1%), 16.3%...