A5014676276- Liver physiology and pathology
- Liver Disease Diagnosis and Treatment
- Pesticide Residue Analysis and Safety
- Insect and Pesticide Research
- Zebrafish Biomedical Research Applications
- Hepatocellular Carcinoma Treatment and Prognosis
- Mycotoxins in Agriculture and Food
- Pesticide Exposure and Toxicity
- Liver Disease and Transplantation
- Fatty Acid Research and Health
- Carcinogens and Genotoxicity Assessment
- Anorectal Disease Treatments and Outcomes
- Metabolomics and Mass Spectrometry Studies
- Vitamin C and Antioxidants Research
- Colorectal Cancer Surgical Treatments
- Spectroscopy Techniques in Biomedical and Chemical Research
- Pesticide and Herbicide Environmental Studies
- Effects and risks of endocrine disrupting chemicals
- Antibiotics Pharmacokinetics and Efficacy
- Pharmaceutical and Antibiotic Environmental Impacts
- Neurological Disease Mechanisms and Treatments
- Pancreatitis Pathology and Treatment
- Nephrotoxicity and Medicinal Plants
- Organ Transplantation Techniques and Outcomes
- Wheat and Barley Genetics and Pathology
Institute of Quality Standards and Testing Technology for Agro Products
2019-2024
Hubei Academy of Agricultural Sciences
2024
Ministry of Agriculture and Rural Affairs
2021-2024
Chinese Academy of Agricultural Sciences
2019-2024
The People's Hospital of Guangxi Zhuang Autonomous Region
2008
Tongji Hospital
2003-2007
Huazhong University of Science and Technology
2003-2007
Affiliated Hospital of Guilin Medical College
2006-2007
Wuhan College
1982
As the most prevalent mycotoxin in agricultural products, aflatoxin B1 not only causes significant economic losses but also poses a substantial threat to human and animal health. AFB1 has been shown increase risk of hepatocellular carcinoma (HCC) underlying mechanism is thoroughly researched. Here, we explored toxicity on hepatocytes following low-dose exposure based transcriptomics lipidomics. Apoptosis-related pathways were significantly upregulated after all three hES-Hep, HepaRG, HepG2...
Maternal exposure to antibiotics existing in the environment is a predisposing factor for developmental malformation with metabolic disorders offspring. In this study, female zebrafish (3 months) were exposed 0.05 mg/L and 0.5 florfenicol (FF) 28 days. After pairing spawning healthy male fish, F1 embryos collected developed 5 d post-fertilization (dpf) clear water. And adverse effects on generation examined thoroughly. The fecundity of F0 fish hatchability, mortality, body length larvae...
Bisphenol G (BPG), bisphenol M (BPM) and TMC (BPTMC), are newly recognized analogues of A (BPA), which have been detected in multiple environmental media. However, the understanding their negative impacts on health is limited. In this study, zebrafish embryos were exposed to BPA three (0.1, 10, 1000 μg/L) identify developmental toxic effects. According our results, all induced significant disorders including inhibited yolk sac absorption, altered heart rate, teratogenic Oil Red O staining...
Goat milk is considered the optimal substitute for human and characterized by variations in lipid composition of its fat globules across lactation phases. Therefore, objective this study was to thoroughly analyze differences between goat during different lactations milk, aiming offer scientific guidance production functional dairy products. Compared with transitional mature findings indicated that total membrane protein content colostrum exhibited greater similarity found milk. Additionally,...
The value of serum bile acid concentrations for predicting prognosis in cirrhotics was compared with the prognostic significance clinical and laboratory findings a prospective 1–year study 76 patients cirrhosis. A commercial radioimmunoassay total serum–conjugated primary acids used. Of patients, 16 died within follow–up period. concentration more closely correlated mortality cirrhosis than commonly used parameters such as Number Connection Test, ascites, albumin, pseudocholinesterase,...
Deoxynivalenol (DON), a mycotoxin produced by Fusarium species that infect cereal grains, including wheat, is significant food safety concern because of its adverse gastrointestinal effects and potential immunotoxicity. In 2015, the Codex Alimentarius Commission United Nations set guidelines for maximum allowable DON in wheat other grains. this analysis, we employ social network models to analyze global trade patterns years before after were enacted 2015: each year from 2012 2018 inclusive....
The widespread use of pesticides performs a vital role in safeguarding crop yields and quality, providing the opportunity for multiple to co-exist, which poses significant potential risk human health. To assess toxic effects caused by exposures individual (chlorpyrifos, carbofuran acetamiprid), binary combinations ternary combinations, combined exposure models were developed using HepG2 cells types pesticide mixtures assessed concentration addition (CA), independent action (IA) combination...
Emerging studies demonstrate that inflammation plays a crucial role in the pathogenesis of bipolar disorder (BD), but underlying mechanism remains largely unclear. Given complexity BD pathogenesis, we performed high-throughput multi-omic profiling (metabolomics, lipidomics, and transcriptomics) zebrafish brain to comprehensively unravel molecular mechanism. Our research proved zebrafish, JNK-mediated neuroinflammation altered metabolic pathways involved neurotransmission. On one hand,...
Inflammation-related diseases present a significant public health problem. Ginger is flavoring spice and medicinal herb with anti-inflammatory activity. This study investigated the preventive effects of ginger extract (GE) its main bioactive component, 6-gingerol (6G), on lipopolysaccharide (LPS)-induced intestinal barrier dysfunction liver injury in mice.
The natural co-occurrence of multiple mycotoxins has been reported in cereals and cereal products worldwide. Even though the dietary exposure to constitutes a serious human health, most reports are limited toxic effect individual mycotoxins. purpose present study was assess combined effects zearalenone (ZEN) fumonisin B1 (FB1) potential interaction their mixture on zebrafish (Danio rerio) embryos. Our results showed that ZEN possessed higher toxicity embryonic (7-day LC50 value 0.78 mg a.i....
In the tea-planting process, insecticides are commonly combined, potentially prolonging pre-harvest interval and heightening risk of dietary exposure. This study focused on three frequently used in tea cultivation: thiamethoxam, bifenthrin, dinotefuran, aiming to investigate their dissipation behaviors associated risks upon individual simultaneous application. The kinetics dinotefuran were successfully characterized by first-order kinetics, yielding respective half-lives 5.44, 9.81, 10.16...
Sinensetin is a polymethoxylated flavone with anti-inflammatory and anti-oxidative activities. This work aimed to explore the function mechanism of sinensetin in oxygen glucose deprivation/reperfusion (OGD/R)-induced neurotoxicity. The overlapping target genes cerebral stroke were determined according GeneCards ParmMapper tools subjected Gene Ontology (GO) annotations Kyoto Encyclopedia Genes Genomes (KEGG) pathway enrichment analyses. Human microvascular endothelial cells (HCMECs)...
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