A5103128400- Epilepsy research and treatment
- Endoplasmic Reticulum Stress and Disease
- Hematopoietic Stem Cell Transplantation
- Adipose Tissue and Metabolism
- Immune Cell Function and Interaction
- Genetics and Neurodevelopmental Disorders
- Autoimmune Neurological Disorders and Treatments
- Microplastics and Plastic Pollution
- Clinical Nutrition and Gastroenterology
- Mesenchymal stem cell research
- Neonatal Respiratory Health Research
- Acute Myeloid Leukemia Research
- Renal cell carcinoma treatment
- Effects and risks of endocrine disrupting chemicals
- Autophagy in Disease and Therapy
- Epigenetics and DNA Methylation
- Complement system in diseases
- Platelet Disorders and Treatments
- Peripheral Neuropathies and Disorders
- Immune cells in cancer
- Salivary Gland Disorders and Functions
- Luminescence Properties of Advanced Materials
- Pharmacological Effects of Medicinal Plants
- Hepatitis B Virus Studies
- Biliary and Gastrointestinal Fistulas
Shandong University
2020-2025
Peking University
2013-2025
Peking University Third Hospital
2022-2025
Qilu Hospital of Shandong University
2020-2024
Chinese Academy of Agricultural Sciences
2023-2024
Tianjin Medical University
2016-2024
Institute of Quality Standards and Testing Technology for Agro Products
2023-2024
Shanghai University
2024
Inner Mongolia Agricultural University
2024
Inner Mongolia Academy of Agricultural & Animal Husbandry Sciences
2024
Bisphenol G (BPG), bisphenol M (BPM) and TMC (BPTMC), are newly recognized analogues of A (BPA), which have been detected in multiple environmental media. However, the understanding their negative impacts on health is limited. In this study, zebrafish embryos were exposed to BPA three (0.1, 10, 1000 μg/L) identify developmental toxic effects. According our results, all induced significant disorders including inhibited yolk sac absorption, altered heart rate, teratogenic Oil Red O staining...
Abstract Background Hepatolithiasis frequently presents with recurring cholangitis and complications. Oddi sphincter‐preserved cholangioplasty hepatico‐subcutaneous stoma (OSPCHS), introduced in 1993, has shown favorable long‐term results. Endoscopic sphincterotomy (EST) is commonly used, but its impact on OSPCHS outcomes remains unclear. Methods From January 1993 to June 2021, 254 patients hepatolithiasis underwent OSPCHS. A total of 31 had prior EST (group EST, n = 31), while 223 did not...
ABSTRACT Aims To predict the progression of children with self‐limited epilepsy centrotemporal spikes (SeLECTS) to epileptic encephalopathy spike‐and‐wave activation in sleep (EE‐SWAS). Methods We conducted a retrospective analysis early clinical and electroencephalography (EEG) data. Clinical parameters included demographic epilepsy‐related characteristics. EEG were qualitatively (localization, lateralization, synchrony, non‐Rolandic discharges, nondipole spikes, multiple focal slow‐wave...
Abstract CTRP9 has been reported to regulate lipid metabolism and exert cardioprotective effects, yet its role in high‐fat diet (HFD)‐induced cardiac lipotoxicity the underlying mechanisms remain unclear. In current study, we established HFD‐induced obesity model wild‐type (WT) or knockout (CTRP9‐KO) mice palmitate‐induced neonatal rat myocytes (NRCMs) investigate effects of on lipotoxicity. Our results demonstrated that HFD‐fed CTRP9‐KO accentuated hypertrophy, fibrosis, endoplasmic...
Lanthanide-doped upconversion nanoparticles (Ln-UCNPs) have been considered promising materials for various fields, such as biomedical and industrial applications. However, data reports regarding its toxicity environmental risks are scarce. Under these circumstances, must be obtained to fully understand potential adverse outcome pathways. In the present study, of uncoated Ln-UCNP cores (NaYF
Objective Vagus nerve stimulation (VNS) has been widely used in the treatment of drug-resistant epilepsy (DRE) children. We aimed to explore efficacy and safety VNS, focusing on factors that can influence construct a prediction model for VNS DRE Methods Retrospectively analyzed 45 children who underwent at Qilu Hospital Shandong University from June 2016 November 2022. A ≥50% reduction seizure frequency was defined as responder, logistic regression analyses were performed analyze affecting...
Soil microbial communities play a crucial role in maintaining diverse ecosystem functions within the saline-alkali soil ecosystems. Therefore, this study, we collected various saline-alkaline soils from across Inner Mongolia Hetao irrigation area. The chemical properties were analyzed, and diversity of bacteria fungi was measured using 16 S rRNA ITS amplicon sequencing. dynamic relationship between community factors analyzed ABT (Aggregate Enhanced tree) model, co-occurrence network,...
Lignin is considered a promising carrier for drugs with aromatic structures via co-self-assembly, endowing the composite particles functional properties biomedical applications. Triiodothyronine (T3) has exhibited beneficial effects in obesity and obesity-related metabolic disorders by increasing energy expenditure of adipose tissue; however, excess thyroid hormones may adversely affect various tissues. T3, which contains benzene rings hydrophilic groups, co-self-assembled lignin to...
Myelodysplastic syndrome (MDS) is a heterogeneous group of clonal hematopoietic stem cell disorders. Studies have shown the involvement an abnormal immune system in MDS pathogenesis. The gut microbiota are known to influence host immunity and metabolism, thereby contributing development diseases. In this study, we performed microbiome plasma metabolomic analyses patients with healthy controls. We found that had different microbial composition compared showed continuous evolutionary...
Objective: To determine whether cyclosporine A (CsA) plus androgens was as effective the current standard immunosuppressive therapy (IST) for transfusion-dependent nonsevere aplastic anemia (TD-NSAA). Methods: The records of 125 consecutive TD-NSAA patients who were treated between Aug. 2007 and Sept. 2014, with either CsA androgen or ALG/ATG regimen reviewed. 3-month 6-month hematologic responses survival evaluated. Results: There (70 male 55 female, 1.25∶1). Median age 27 (6-66) years. no...
Objective: To retrospectively investigate the clinical characteristics, risk factors of Cytomegalovirus (CMV) infection in patients with underlying rheumatic diseases. Methods: Clinical records 263 or without CMV infection, hospitalized from March 2011 to June 2014 Peking University People's Hospital, were analyzed.Clinical characteristics summarized and compared positive negative groups, for infection.Statistical analyses conducted SPSS 20.0 software. Results: A total 62 found have 48...
To analyze the clinical characteristics and to evaluate immunosuppressive therapy (IST) response survival in hepatitis-associated aplastic anemia (HAAA).We retrospectively analyzed characteristics, IST response, long-term clonal evolution 41 HAAA patients, compared those with age bone marrow failure matched idiopathic (IAA) patients.The prevalence of among cases SAA was 4.34% (41/944). The proportion VSAA significantly higher than IAA (65.9% vs 39.4%, P=0.001). There no significant...
Objective: To explore the characteristics of delayed hematologic response in very/severe aplastic anemia (V/SAA) patients who were treated with immunosuppressive treatment (IST) as first-line approach, and investigate rationality early salvage refractory patients. Methods: The data V/SAA front-line IST retrospectively analyzed. Delayed was defined acquiring between 6 12 months after 1 course IST. clinical well responded investigated. Results: Of 533 patients, 45 (8.44%, 45/533) responders,...