A5100327180- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Ferroptosis and cancer prognosis
- Extracellular vesicles in disease
- RNA Research and Splicing
- Cancer-related gene regulation
- Immune cells in cancer
- MRI in cancer diagnosis
- Atherosclerosis and Cardiovascular Diseases
- Natural Antidiabetic Agents Studies
- RNA and protein synthesis mechanisms
- Chronic Kidney Disease and Diabetes
- Barrier Structure and Function Studies
- Cancer Research and Treatments
- Cancer Cells and Metastasis
- Mycobacterium research and diagnosis
- Crystal structures of chemical compounds
- Liver Disease Diagnosis and Treatment
- Advanced Glycation End Products research
- Signaling Pathways in Disease
- Synthesis and biological activity
- Bone Metabolism and Diseases
Nanjing Medical University
2021-2023
Jiangsu Province Hospital
2021-2023
First Affiliated Hospital of Zhengzhou University
2023
Shandong Provincial Hospital
2021-2022
Shandong University
2021-2022
Xi'an Jiaotong University
2022
Xi'an Honghui Hospital
2022
Guangzhou University of Chinese Medicine
2021
Second Affiliated Hospital of Jilin University
2015-2021
Wuxi No.2 People's Hospital
2021
MicroRNAs (miRNAs) play important roles in carcinogenesis. The global miRNA expression profile of gastric cancer has not been reported. purpose the present study was to determine cancer.Total RNA were first extracted from primary tissues and adjacent non-tumorous then small isolated RNAs (< 300 nt) 3'-extended with a poly(A) tail. Hybridization carried out on microParaflo microfluidic chip (LC Sciences, Houston, TX, USA). After hybridization detection by fluorescence labeling using...
Current studies on tumor progression focus the roles of cytokines in microenvironment (TME), and recent research shows that transforming growth factor-β1 (TGF-β1) released from TME plays a pivotal role development malignant transformation. The alteration cellular metabolism is hallmark cancer, which not only provides cancer cells with ATP for fuel reactions, but also generates metabolic intermediates synthesis essential ingredients, to support cell proliferation, migration, invasion....
Type 2 diabetes mellitus (T2DM) is a metabolic disease with high incidence, which has seriously affected human life and health. MicroRNA, short-chain noncoding RNA, plays an important role in T2DM. Identification of meaningful microRNA modules the microRNAs provide basis for searching potential biomarkers T2DM.In this study, three newly diagnosed patients T2DM controls were selected Whole Peripheral Blood RNA Sequencing to establish library. Weighted gene coexpression network analysis...
Abstract Lung adenocarcinoma is recognized as one of the most recurrent tumours in adults. Long non‐coding RNAs (lncRNAs) are non–protein‐coding transcripts and have been demonstrated to regulate biological functions during tumorigenesis. Our study aims investigate underlying molecular mechanisms LINC00461/microRNA‐195 (miR‐195)/HOXA10 responsible for its involvement lung adenocarcinoma. We firstly selected differentially expressed lncRNAs genes by Cancer Genome Atlas (TCGA) database Gene...
Purpose: Osteoporosis, a common disorder especially prevalent in the postmenopausal women and elderly, is becoming worldwide public health problem. Osteoporosis can cause severe joint pain, fragility fractures, other symptoms, which seriously impair daily lives of affected patients. Currently, no gold-standard drug available that completely cure osteoporosis. Tanshinone traditional Chinese medicine, exhibit multiple biological activities. It might also display protective effect on However,...
We aimed to investigate differentially expressed long non-coding RNAs (lncRNAs) and messenger (mRNAs) in atherosclerosis validate the expression of lncRNAs co-expressed target genes proliferation migration models human coronary artery smooth muscle cells (HCASMCs). Ten specimens from a subject who died heart attack were employed. The pathological analysis was analyzed by hematoxylin eosin (H&amp;E) staining, mRNAs identified RNA sequencing. Bioinformatic analyses performed predict...
Colon carcinoma is one of the most common cancers worldwide. Epidemiological studies have revealed that colon cancer third leading cause cancer‑related deaths, which due to increased incidence and mortality rates. However, treatment strategies for remain unsatisfactory patients, especially those with advanced or recurrent cancer. Dysregulated microRNAs (miRNAs) are considered influence tumor development metastasis. molecular mechanism through miRNAs affect progression not yet completely...
Low-grade glioma (LGG) is a common malignant tumor of the central nervous system. The clinical prognosis different patients varies greatly, so exploring appropriate markers that affect and treatment LGG important. purpose this study was to identify potential effect autophagy-related DNA methylation on immune microenvironment in LGG.The profile, transcription data corresponding information 451 with were obtained from Cancer Genome Atlas (TCGA). Another 110 Chinese Glioma (CGGA) used as...
This study aimed to investigate the role of hypoxia-inducible factor-2α (HIF-2α) in expression tight junction proteins and permeability alterations rat glomerular endothelial cells (rGENCs) under hypoxia conditions. The level HIF-2α (occludin ZO-1) rGENCs were examined following 5% oxygen density exposure at different treatment times. lentivirus transfection was used knockdown expression. Cells divided into four groups: 1) control group (rGENCs cultured normal conditions), 2) hypoxic 3)...
Abstract Multiple myeloma (MM) is the second incurable hematological malignancy. In recent years, due to rise of microRNA (miRNA), many scholars have participated in study its value diagnosis MM, and obtained good but inconsistent results. Therefore, order determine role miRNA early we searched for related studies including PubMed, Web Science, EMBASE, Cochrane Library, China National Knowledge Infrastructure (CNKI) Wanfang Database as July 20, 2020 conduct this meta-analysis. To improve...
The title compound, C(8)H(10)O(5)·C(2)H(3)N(3)S·H(2)O, was synthesized by the reaction of 2-amino-1,3,4-thia-diazole with norcantharidin. crystal structure is stabilized N-H⋯O, N-H⋯N, O-H⋯O and O-H⋯N hydrogen bonds. In addition, weak π-π inter-actions are observed between symmetry-related thia-diazole ring systems [centroid-centroid distance = 3.9110 (3) Å, inter-planar spacing 3.4845 Å].
Objective To investigate the role of hypoxia-inducible factor-2α (HIF-2α) in expression tight junction proteins and permeability alterations rat glomerular endothelial cells (rGENCs) under hypoxia condition. Methods The expressions HIF-2α such as occludin ZO-1 rGENCs were examined after exposed to 5% oxygen at different treatment time periods (0 h, 12 24 h 48 h). Then lentiviral transfection was used knock down rGENCs. The split into four groups, including i) control group where...
Abstract Background Gastric cancer (GC) is a malignant tumor with high incidence rate and mortality. Due to the lack of effective diagnostic indicators, most patients are diagnosed in late stage have poor prognosis. An increasing number studies proved that PPIA can play an oncogene role various types. However, precise mechanism GC still unclear. Methods The mRNA levels pan-cancer prognostic value on was evaluated using multiple databases. Additionally, relationship between expression...
Lung cancer is the most common and leading cause of cancer-related deaths in men women globally. Increasing evidence has demonstrated that microRNAs (miRNAs) may be critical regulators processes. Therefore, understanding molecular mechanism between Non-Small Cell Cancer (NSCLC) abnormal miRNA expression levels help identify novel diagnostic biomarkers therapeutic targets for patients with NSCLC. MiRNA-18b (miR-18b) abnormally expressed multiple types human cancers. However, pattern, function...
Abstract Background: The mortality rate of hepatocellular carcinoma（HCC）is the third highest worldwide. Infection with hepatitis B virus (HBV）is an important risk factor for development HCC. fact that there is no available target drug HCC highlights necessity to further explore its underlying mechanism. Methods: Gene expression profiles GSE121248, GSE55092 and GSE62232 were accessible from GEO database. From 129 tissues 138 normal in three profile datasets, we picked out differentially...