A5040947855- Chronic Kidney Disease and Diabetes
- Barrier Structure and Function Studies
- Advanced Glycation End Products research
- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- Telomeres, Telomerase, and Senescence
- Renin-Angiotensin System Studies
- Acute Kidney Injury Research
- Biomedical Ethics and Regulation
- Pregnancy and preeclampsia studies
- Renal Diseases and Glomerulopathies
- Receptor Mechanisms and Signaling
- Acute Myocardial Infarction Research
- Electrolyte and hormonal disorders
- Sepsis Diagnosis and Treatment
- Hormonal Regulation and Hypertension
- MRI in cancer diagnosis
- Molecular Biology Techniques and Applications
- Health, Environment, Cognitive Aging
- Neonatal Respiratory Health Research
- Cardiac Imaging and Diagnostics
- High Altitude and Hypoxia
- Coronary Interventions and Diagnostics
- Tissue Engineering and Regenerative Medicine
- Gestational Diabetes Research and Management
Qinghai University
2008-2024
Qinghai University Affiliated Hospital
2016-2024
Southern Medical University
2024
Nanfang Hospital
2024
Sun Yat-sen University
2013
Background Endothelial dysfunction is an early sign of diabetic cardiovascular disease and may contribute to progressive nephropathy (DN). There increasing evidence that the endothelial tight junction a crucial step in development hyperpermeability, but it unknown whether this occurs glomerular cells (GEnCs) during progression DN. We examined GEnCs early-stage DN potential underlying mechanisms. also effect simvastatin (3-Hydroxy-3-methylglutaryl CoA reductase inhibitor) on junctions...
The effects of 5-methoxytryptophan (5-MTP) on mitophagy in sepsis-induced acute kidney injury (S-AKI) and its possible role the Nrf2/HO-1 signaling pathway are unclear. In this study, we aimed to examine levels serum 5-MTP patients with S-AKI evaluate influence a lipopolysaccharide(LPS)-induced AKI model. Additionally, sought elucidate mechanisms by which regulates via Nrf2 mediation.
Activation of the intrarenal renin‑angiotensin system (RAS), which has been identified in podocytes and mesangial cells, is a novel mechanism progression diabetic kidney disease (DKD). The present study aimed to identify local RAS glomerular endothelial cells (GEnCs). Rat GEnCs were stimulated by culture medium containing 30 mmol/l glucose for 12, 24, 48 72 h. Angiotensin II (Ang II) concentrations cell lysates media examined ELISA mRNA levels angiotensinogen renin analyzed quantitative...
The present study aimed to investigate the effects of advanced glycation end‑products (AGEs) on permeability glomerular endothelial cells (GEnCs) and determine whether enhanced was due degradation tight junction (TJ) complexes by matrix metalloproteinases (MMPs). Cultured monolayers GEnCs were exposed AGEs at different doses treatment durations in presence or absence organic MMP‑2/9 inhibitor (2R)‑2‑((4‑biphenyl sulfony‑l)amino)‑3‑phenylproprionic acid) (BiPs). Expression TJ proteins...
This study aimed to investigate the role of hypoxia-inducible factor-2α (HIF-2α) in expression tight junction proteins and permeability alterations rat glomerular endothelial cells (rGENCs) under hypoxia conditions. The level HIF-2α (occludin ZO-1) rGENCs were examined following 5% oxygen density exposure at different treatment times. lentivirus transfection was used knockdown expression. Cells divided into four groups: 1) control group (rGENCs cultured normal conditions), 2) hypoxic 3)...
The diagnosis of acute myocardial infarction (AMI) using high-sensitivity cardiac troponin T (hs-cTnT) remains challenging in patients with kidney dysfunction. In this large, multicenter cohort study, a total 20 912 adults who underwent coronary angiography were included. Kidney function-specific cut-off values hs-cTnT determined to improve the specificity without sacrificing sensitivity, as compared that traditional value (14 ng/L) normal function group. diagnostic accuracy novel was...
Podocytopathies encompass kidney diseases where direct or indirect podocyte injury leads to proteinuria nephrotic syndrome. Although Semaphorin3A (Sema3A) is expressed in podocytes and tubular cells adult mammalian kidneys has a common effect on the progression of injury, its mechanism remains unclear. Previous studies have shown increased Sema3A expression various glomerulopathies, indicating gap understanding role. In this study, analysis human data revealed positive correlation between...
Objective To investigate the role of hypoxia-inducible factor-2α (HIF-2α) in expression tight junction proteins and permeability alterations rat glomerular endothelial cells (rGENCs) under hypoxia condition. Methods The expressions HIF-2α such as occludin ZO-1 rGENCs were examined after exposed to 5% oxygen at different treatment time periods (0 h, 12 24 h 48 h). Then lentiviral transfection was used knock down rGENCs. The split into four groups, including i) control group where...