A5101548269- Cerebrovascular and Carotid Artery Diseases
- SARS-CoV-2 and COVID-19 Research
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Biofuel production and bioconversion
- Bone Metabolism and Diseases
- Pomegranate: compositions and health benefits
- Peripheral Nerve Disorders
- Lung Cancer Treatments and Mutations
- Atherosclerosis and Cardiovascular Diseases
- Musculoskeletal pain and rehabilitation
- Wnt/β-catenin signaling in development and cancer
- Spondyloarthritis Studies and Treatments
- Medical Imaging and Analysis
- TGF-β signaling in diseases
- Advanced Proteomics Techniques and Applications
- Abdominal vascular conditions and treatments
- Thermochemical Biomass Conversion Processes
- vaccines and immunoinformatics approaches
- Musculoskeletal synovial abnormalities and treatments
- Neurological Disease Mechanisms and Treatments
- Ubiquitin and proteasome pathways
- Medicinal Plant Pharmacodynamics Research
- Mesenchymal stem cell research
- Phytase and its Applications
Second People’s Hospital of Yibin
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2011-2024
Peking Union Medical College Hospital
2011-2024
CHN Energy (China)
2022
First Affiliated Hospital of Guangzhou University of Chinese Medicine
2019-2021
Guangzhou University of Chinese Medicine
2019-2021
XinHua Hospital
2015-2019
Shanghai Jiao Tong University
2017-2019
Nanjing General Hospital of Nanjing Military Command
2017
Southern Medical University
2017
Apigenin (API), a natural plant flavone, is abundantly found in common fruits and vegetables. As bioactive flavonoid, API exhibits several activities including antiproliferation anti-inflammation. A recent study showed that could retard osteoporosis progress, indicating its role the skeletal system. However, detailed function mechanism remain obscure. In present study, was to promote osteogenic differentiation of mesenchymal stem cells (MSCs). And further investigation enhance expression...
Abstract Consumption of dietary ellagitannins (ETs) has been proven to benefit multiple chronic health disorders including cancers and cardiovascular diseases. Urolithins, gut microbiota metabolites derived from ETs, are considered as the molecules responsible for these effects. Previous studies have demonstrated that urolithins exhibit antiproliferative effects on prostate, breast, colon cancers. However, hepatocellular carcinoma (HCC), it remains elusive. Herein, we aim investigate...
Abstract Background Currently, noninvasive imaging techniques and circulating biomarkers are still insufficient to accurately assess carotid plaque stability, an in-depth understanding of the molecular mechanisms that contribute instability is lacking. Methods We established a clinical study cohort containing 182 patients with artery stenosis. After screening, 39 stable 49 unstable plaques were included in discovery group, quantitative proteomics analysis based on data independent...
As a leading cause of cancer related death in the world, hepatocellular carcinoma (HCC) continues to be attracted various attention recent decades. The traditional Chinese herb has been practiced for thousands years which provides promising potential treatment HCC. Curcumin, bioactive ingredient derived from Curcuma longa, exhibits anti-tumor activity cancers. Although effects Curcumin on HCC elucidated, underlying mechanism remains unclear. In present study, was demonstrated inhibit...
Background: Carotid artery stenosis (CAS) is caused by the formation of atherosclerotic plaques inside arterial wall and accounts for 20–30% all strokes. The development an early, noninvasive diagnostic method identification high-risk patients ischemic stroke essential to management CAS in clinical practice. Methods: We used data-independent acquisition (DIA) technique conduct a urinary proteomic study with healthy controls. identified potential diagnosis risk stratification biomarkers CAS....
Neutralizing antibodies (nAbs) play an important role against SARS-CoV-2 infections. Previously, we have reported one potent receptor binding domain (RBD)-binding nAb Ab08 the prototype and a panel of variants, but showed much less efficacy variants harboring L452R mutation. To overcome antibody escape caused by mutation, generated several structure-based derivatives. One derivative, Ab08-K99E, displayed mostly enhanced neutralizing potency Delta pseudovirus bearing mutation compared to...
<title>Abstract</title> <bold>Objective</bold>: To investigate the safety and clinical effectiveness of Arthroscopic-assisted Uni-portal Spinal Surgery(AUSS)combined with bone anchoringannulus fibrosus suture technique in treatment lumbar disc herniation(LDH) vertebral edge annulus tear. <bold>Methods</bold>: A total 52 patients LDH tear from March 2019 to 2023 our hospital were included this study.All treated by AUSS combined anchoring technique.The visual analog scale (VAS) score for lower...
Proteases are involved in the degradation of extracellular matrix (ECM), which contributes to formation abdominal aortic aneurysm (AAA). To identify new disease targets addition results previous microarray studies, we performed next-generation sequencing (NGS) whole transcriptome Angiotensin II-treated ApoE −/− male mice (n = 4) and control obtain differentially expressed genes (DEGs). Identified DEGs proteases were analyzed using weighted gene coexpression network analysis (WGCNA). RT-qPCR...
Ewing sarcoma is a malignant bone tumor mainly affecting teenagers and young adults. Its main driver mutation, the EWS-FLI1 fusion gene, has been identified more than 20 years ago, whereas its other somatic mutations have just recently reported.In this study, we organized from 216 cases into individual protein-protein interaction networks by using interactome information. These mutation were then classified five different clusters based on their structural similarities. The prognostic effect...
The IL ‐1 β gene is currently topic of interest for its important role in the pathogenesis intervertebral disk degeneration. new sequencing technology makes it crucial to study effects variants β. Thus, 714 with evidence supporting were collected from EMBL database. Among them, 62 non‐synonymous single nucleotide (ns SNV s). Furthermore, six common ns s predicted have damaging by SIFT , PolyPhen, PROVEAN and SNP s& GO . Based on constructed three‐dimensional structure pro‐ ‐1β,...