A5010397591- Cerebrovascular and Carotid Artery Diseases
- Peripheral Artery Disease Management
- Aortic aneurysm repair treatments
- Venous Thromboembolism Diagnosis and Management
- Neurological Disease Mechanisms and Treatments
- Intracranial Aneurysms: Treatment and Complications
- Circadian rhythm and melatonin
- Cardiovascular Health and Disease Prevention
- Angiogenesis and VEGF in Cancer
- Aortic Disease and Treatment Approaches
- Phagocytosis and Immune Regulation
- Atherosclerosis and Cardiovascular Diseases
- Cardiac, Anesthesia and Surgical Outcomes
- Cancer-related molecular mechanisms research
- Moyamoya disease diagnosis and treatment
- Renal and Vascular Pathologies
- Heme Oxygenase-1 and Carbon Monoxide
- Antioxidant Activity and Oxidative Stress
- Inflammasome and immune disorders
- RNA modifications and cancer
- Ocular Diseases and Behçet’s Syndrome
- GDF15 and Related Biomarkers
- COVID-19 Clinical Research Studies
- Retinal and Optic Conditions
- Air Quality and Health Impacts
Peking Union Medical College Hospital
2016-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2025
National Institute on Aging
2018-2021
Institute on Aging
2021
National Institutes of Health
2018-2021
University of Hong Kong
2019
Queen Mary Hospital
2019
Center for Vascular Biology Research
2016
Huizhou Central People's Hospital
2014
Union Hospital
2010
Abstract Carotid endarterectomy ( CEA ) is the treatment of choice for carotid stenosis. Some patients develop ischemia and reperfusion (I/R) injury after . This study was designed to investigate neuroprotective effects melatonin on I/R in both rats humans. To this end, 36 male were evaluated, a double‐blind randomized controlled trial RCT including 60 performed. A rat model middle cerebral artery occlusion used mimic I/R. After 2 hour 24 reperfusion, blood samples brain tissues harvested...
Disruption of endothelial cell function is a principle event in cardiovascular disease. Accordingly, therapies have mostly focused on repairing the endothelium, but little attention has been paid to reconstruction glycocalyx, which covers endothelium and protects cells. Sulodexide similar glycosaminoglycan structure so it assumed be effective remodeling glycocalyx following damage. We assessed effect sulodexide balloon-injury rat carotid artery model. Electron micrographs showed that...
Substantial evidence suggests that the effects of smoking in atherosclerosis are associated with inflammation mediated by endothelial cells. However, mechanisms and potential drug therapies for smoking-induced remain to be clarified. Considering melatonin exerts beneficial cardiovascular diseases, we examined its on cigarette smoke-induced vascular injury. We found smoke extract (CSE) treatment induced NLRP3-related pyroptosis human aortic cells (HAECs). CSE also ROS generation upregulated...
Smoking is one of the most harmful lifestyles in world. Very few studies have investigated effects melatonin smoke-induced vascular injury. This study was designed to investigate whether could protect rats and humans from 32 male a double-blind randomized controlled trial (RCT) containing 63 participants formed subjects this study. In rats, 10 mg/kg intraperitoneally injected. Blood samples abdominal artery were harvested two weeks later. Melatonin decreased expression platelet endothelial...
Endothelial injury induced by hyperglycemia is the most critical initial step in development of diabetic vasculopathy. The aim this present study was to explore prevention and treatment strategies elucidate specific mechanism diabetes‑induced vascular endothelial injury. Melatonin, a hormone secreted pineal gland regulate biological rhythm, serves an important role maintaining human physiological function. Pyroptosis type newly discovered inflammatory cell death. current first found western...
Abstract Epidemiology survey indicated that cigarette smoking is a risk factor of diabetes. However, the precise mechanisms remain to be clarified. In this study, we found caused metabolic malfunctions on pancreas and liver in experimental animal model. These were by hyperglycemia, increased serum hemoglobin A1c level decreased insulin secretion, inhibition glycogen synthase ( LGS ), hepatic synthesis. Mechanistic studies revealed all these alterations inflammatory reaction reactive oxygen...
Vascular restenosis after the interventional angioplasty remains main obstacle to a favorable long-term patency. Many researches suggest cigarette smoking is one of most important causes restenosis. This study was designed investigate whether melatonin could protect against smoke-induced in rat carotid arteries balloon injury. Three groups male rats (normal condition, smoke exposed, and injected) were used this study. An established balloon-induced artery injury performed, harvested from...
The aim of this study was to investigate the safety and effectiveness endovascular stenting for extracranial carotid artery aneurysms (ECAAs) evaluate mid-term outcomes.Twelve consecutive symptomatic patients (mean age 43.8 ± 14.9 years; 8 men) with ECAAs who were treated between 1997 2015 retrospectively analyzed. Clinical follow-up data including symptoms neurological events obtained from outpatient records. Imaging duplex ultrasound and/or computed tomographic angiography (CTA) performed...
tRNA-derived fragments (tRFs) are a new class of non-coding RNAs involved in variety pathological processes, but their biological functions and mechanisms human aortic smooth muscle cells (HASMCs) phenotype transition vascular intimal hyperplasia unclear.tiRNA-Gly-GCC is upregulated synthetic HASMCs, atherosclerotic arteries, plasma, the balloon injured carotid artery rats. Functionally, inhibition tiRNA-Gly-GCC represses HASMCs proliferation, migration, reversed dedifferentiation, whereas...
Background Aging exponentially increases the incidence of morbidity and mortality quintessential cardiovascular disease mainly due to arterial proinflammatory shifts at molecular, cellular, tissue levels within wall. Calorie restriction ( CR ) in rats improves function extends both health span life span. How affects landscape phenotypic wall rats, however, remains be elucidated. Methods Results Aortae were harvested from young (6-month-old) old (24-month-old) Fischer 344 fed ad libitum a...
转运RNA来源的小RNA（tsRNA）是一类由转运RNA特异性断裂产生的新型非编码RNA，具有多种调控机制，参与多种疾病的发生、发展过程。近年来，多项研究证实tsRNA在心血管疾病中发挥重要作用。该文主要对tsRNA生物学发生、调控机制及其在心血管疾病中的研究进展进行综述，以期为心血管疾病诊治提供新的研究方向。.
Restenosis after intraluminal or open vascular reconstruction remains an important clinical problem. Vascular endothelial cell (EC) injury induced by oxidative stress plays role in the development of intimal hyperplasia. In this study, we sought to evaluate protective effects Bcl-xl overexpression vitro on stress-induced EC and Akt/endothelial nitric oxide synthase (eNOS) pathway. Human umbilical vein cells (HUVECs) exposed hydrogen peroxide (H2O2, 0.5 mM) were used as experimental model....
The glycosylated protein vasorin physically interacts with the transforming growth factor-beta1 (TGF-β1) and functionally attenuates its fibrogenic signaling in vascular smooth muscle cells (VSMCs) of arterial wall. Angiotensin II (Ang II) amplifies TGF-β1 activation VSMCs wall aging. In this study, we hypothesized that a reduced expression plays contributory role magnifying Ang II-associated current study shows mRNA were significantly decreased both aortic from old (30 mo) vs. young (8 FXBN...
Purpose: The purpose of this study was to improve the immune compatibility and targeting abilities IL10 nanoparticles coated with platelet membrane (IL10-PNPs) by glycosylation engineering in order effectively reduce restenosis after vascular injury. Materials Methods: In study, we removed sialic acids added α (1,2)-fucose (1,3)-fucose glycoprotein, thus IL10-PNPs (IL10-GE-PNPs). vitro vivo experiments were conducted evaluate regulatory effects IL10-GE-PNPs on macrophage polarization, as...
Cigarette smoking, a major independent risk factor of atherosclerosis, can cause oxidative and inflammatory damage vascular tissue. Heme oxygenase-1 (HO-1) is an endogenous cytoprotective enzyme with anti-oxidant role in cells. The aim the present study was to investigate whether HO-1 able protect endothelial cells from induced by cigarette smoking. It observed that smoking induce generation reactive oxygen species (ROS) carotid arteries rats. Hemin, widely used inducer, reduce ROS. In...