A5102747534- Cellular transport and secretion
- Protein Kinase Regulation and GTPase Signaling
- Advanced Photocatalysis Techniques
- Receptor Mechanisms and Signaling
- Molecular Sensors and Ion Detection
- Erythrocyte Function and Pathophysiology
- Hepatitis B Virus Studies
- Cell Adhesion Molecules Research
- Plant biochemistry and biosynthesis
- Advanced biosensing and bioanalysis techniques
- Glycosylation and Glycoproteins Research
- Advanced battery technologies research
- Estrogen and related hormone effects
- Venomous Animal Envenomation and Studies
- Calcium signaling and nucleotide metabolism
- Electrocatalysts for Energy Conversion
- Peptidase Inhibition and Analysis
- Ga2O3 and related materials
- Hepatitis C virus research
- Nitric Oxide and Endothelin Effects
- Electrochemical sensors and biosensors
- Lipid Membrane Structure and Behavior
- ZnO doping and properties
- Monoclonal and Polyclonal Antibodies Research
- Nuclear Receptors and Signaling
University of Science and Technology of China
2011-2025
Nanjing Forestry University
2025
Sichuan University
2025
West China Second University Hospital of Sichuan University
2025
Materials Science & Engineering
2025
Shanghai Mental Health Center
2024
Shanghai Jiao Tong University
2024
Guangzhou Institutes of Biomedicine and Health
2014-2024
State Key Laboratory of Respiratory Disease
2013-2024
Chinese Academy of Sciences
2014-2024
We report a novel kind of oxidized silicon nanospheres (O-SiNSs), which simultaneously possess excellent aqueous dispersibility, high photoluminescent quantum yield (PLQY), ultra photostability, wide pH stability, and favorable biocompatibility. Significantly, the PLQY O-SiNSs is as 25%, stable under intense UV irradiation in acidic-to-basic environments covering range 2−12. To our best knowledge, it first example water-dispersed nanoparticles both robust stability suitable for broad utility...
In the past 50 years there have been considerable efforts to identify cellular receptor of hepatitis B virus (HBV). Recently, in vitro evidence from several groups has shown that sodium–taurocholate cotransporting polypeptide (NTCP, which is encoded by SLC10A1 and transports bile acids into hepatic cells enterohepatic recirculation) a strong candidate. particular, p.Ser267Phe variation results loss HBV function. We tested role NTCP as for chronic patients using genetic association study....
Graphitic carbon nitride (g‐C 3 N 4 ) is viewed as a promising visible‐light photocatalyst for industrialization due to its low processing temperature and high chemical stability. However, serious charge recombination caused by incomplete polymerization during direct calcination of nitrogen‐rich precursors significantly limits photocatalytic performances. To boost separation, herein, we propose rational strategy constructing crystalline g‐C /g‐C 4−x S x isotype heterostructure through the...
Two-dimensional (2D) nanostructures are mainly confined to being obtained from intrinsically layered crystals via an exfoliation approach or epitaxial growth method, thereby greatly limiting the choice of 2D available for high-performance optoelectronic devices. Here, we introduce efficient PDMS printing strategy simultaneously realize controllable preparation and subsequent transfer a large-area non-layered Ga2O3 amorphous layer on basis ultrathin oxide skin liquid Ga. More importantly,...
A (GaN)1-x(ZnO)x solid solution as a promising visible-light-driven photocatalyst for overall water splitting has attracted extensive attention. In this work, we proposed template reactive strategy toward the synthesis of band-gap tunable 2D nanosheets thin 14 nm to reduce carrier transportation path and thus efficiently decrease recombination electrons holes. It is demonstrated that enables an ideal morphology structure transformation from hexagonal ZnGa2O4 in nitridation process. After...
Developing non-noble metal catalysts with superior catalytic activity and excellent durability is critically essential to promote electrochemical water splitting for hydrogen production. Morphology control as a promising effective strategy widely implemented change the surface atomic coordination thus enhance intrinsic performance of current electrocatalysts. Herein, series cobalt phosphide (CoP) electrocatalysts tunable morphologies nanosheets, nanowires, nanorods, nanoblocks have been...
The identification of a novel class shark-derived single domain antibodies, named vnarbodies that show picomolar affinities binding to the receptor (RBD) Wuhan and Alpha, Beta, Kappa, Delta, Delta-plus, Lambda variants, is reported. Vnarbody 20G6 17F6 have broad neutralizing activities against all these SARS-CoV-2 viruses as well other sarbecoviruses, including Pangolin coronavirus Bat coronavirus. Intranasal administration effectively protects mice from challenges Beta variants. contain...
Abstract Preeclampsia (PE) is a severe pregnancy complication associated with immune imbalance and placental hypoxia stress. Decidua macrophages (dMφ) are essential at maternal fetal interface, which abnormally activated excessively transformed to the M1-phenotype in PE. High mobility group box 1(HMGB1), released from necrotic cells after injury, accumulates placenta peripheral blood of patients Therefore, this study aims investigate interaction between trophoblasts, exploring how HMGB1...
Pan-BD2 inhibitors have been shown to retain an antileukemia effect and display less dose-limiting toxicities than pan-BET inhibitors. However, it is necessary consider the potential off-target toxicity associated with inhibition of four BET BD2 proteins. To date, no BRD4 domain selective inhibitor has reported. Based on our previous pan-BD2
Chronic hepatitis B (CHB) is a major global health issue. The role of rare genetic variants in CHB has not been elucidated. We aimed to identify allelic predisposing CHB. performed exome sequencing 50 patients who had no identifiable risk factors for and 40 controls were healthy surface antibody-positive, but never received vaccination. selected six variant alleles followed up their association with disease status by Sanger case-control study comprising 1,728 1,636 controls. latter either...
Sorting nexins are phox homology (PX) domain-containing proteins involved in diverse intracellular endosomal trafficking pathways. The PX domain binds to certain phosphatidylinositols and is recruited vesicles rich these lipids. structure of the highly conserved, containing a three-stranded β-sheet, followed by three α-helices. Here, we report crystal structures truncated human SNX11 (sorting nexin 11). reveal that contains novel domain, hereby named extended (PXe) with two additional...
Secreted phospholipases A2s (sPLA2s) are involved in various pathological conditions such as rheumatoid arthritis and cardiovascular disease. Many inhibitors were developed studied clinical trials, but none have reached the market yet. This failure may be attributed to lack of subtype selectivity for these inhibitors. Therefore, more structural information sPLA2 is needed guide selective inhibitor development. In this study, crystal structure human Group IIE (hGIIE), coupled with mutagenesis...
The lysosome-targeted probe CuNI exhibits highly effective fluorescence detection ability for Cu<sup>2+</sup> in aqueous solution and cells. fluorescent enhancement is due to the Cu<sup>2+</sup>-catalyzed hydrolysis of AIE effect hydrolysate MFNI.
Sorting nexin 10 (SNX10), the unique member of SNX family having vacuolation activity in cells, was shown to be involved development autosomal recessive osteopetrosis (ARO) recent genetic studies. However, molecular mechanism disease-related mutations affecting biological function SNX10 is unclear. Here, we report crystal structure human 2.6 Å resolution. The reveals that contains extended phox-homology domain previously proposed. Our study provides structural details those mutations....