A5100445647- Inflammasome and immune disorders
- Cell death mechanisms and regulation
- Toxin Mechanisms and Immunotoxins
- Angiogenesis and VEGF in Cancer
- Enzyme Structure and Function
- RNA and protein synthesis mechanisms
- Extracellular vesicles in disease
- interferon and immune responses
- Wnt/β-catenin signaling in development and cancer
- Bacterial Genetics and Biotechnology
- Sepsis Diagnosis and Treatment
- Ion Channels and Receptors
- Hippo pathway signaling and YAP/TAZ
- Fibroblast Growth Factor Research
- Medicinal Plants and Bioactive Compounds
- Bone and Joint Diseases
- Microbial Metabolism and Applications
- Streptococcal Infections and Treatments
- RNA regulation and disease
- Aldose Reductase and Taurine
- Receptor Mechanisms and Signaling
- Cholinesterase and Neurodegenerative Diseases
- Nicotinic Acetylcholine Receptors Study
- Electrospun Nanofibers in Biomedical Applications
- Inflammatory mediators and NSAID effects
National Institute of Biological Sciences, Beijing
2018-2024
Air Force Medical University
2012-2024
Xijing Hospital
2012-2024
Union Hospital
2022-2024
Huazhong University of Science and Technology
2022-2024
Northeast Normal University
2024
Harvard University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2022
State Key Laboratory of Food Science and Technology
2022
Jiangnan University
2022
Abstract Cross-talk between the Hippo and Wnt pathways has been implicated recently in breast cancer development, but key intersections have yet to be fully defined. Here we report that WBP2, a transcription coactivator binds pathway factor YAP/TAZ, contributes signaling pathogenesis. Clinically, overexpression of WBP2 specimens correlated with malignant progression poor patient survival. In cells, nuclear entry interaction β-catenin was stimulated by Wnt3A, thereby activating TCF-mediated...
Epstein-Barr virus (EBV) and human leukocyte antigen (HLA) polymorphisms are well-known risk factors for nasopharyngeal carcinoma (NPC). However, the combined effects between HLA EBV on of NPC unknown. We applied a causal inference framework to disentangle interaction mediation two host SNPs, rs2860580 rs2894207, variant 163364 with population-based case-control study in NPC-endemic southern China. discovered strong high-risk subtype both SNPs (rs2860580, relative excess due [RERI] = 4.08,...
Under stress conditions, translationally stalled mRNA and associated proteins undergo liquid-liquid phase separation condense into cytoplasmic foci called granules (SGs). Many viruses hijack SGs for their pathogenesis; however, whether pathogenic bacteria also exploit this pathway remains unknown. Here, we report that members of the OspC family Shigella flexneri induce SG formation in infected cells. Mechanistically, effectors target multiple subunits host translation initiation factor 3...
Blocking host cell death is an important virulence strategy employed by many bacterial pathogens. We recently reported that Shigella flexneri inhibits pyroptosis delivering a type III secretion system (T3SS) effector OspC3 catalyzes novel arginine ADP-riboxanation modification on caspase-4/11. Here, we investigated the homologue CopC from Chromobacterium violaceum, opportunistic but sometimes deadly pathogen. bears same ADP-riboxanase activity as OspC3, with different substrate specificity....
The study reports the feasibility and efficiency of vascular endothelial growth factor (VEGF) delivery using nanoparticles synthesized from glycidyl methacrylated dextran (Dex-GMA) gelatin for therapeutic angiogenesis.The were prepared phase separation method, drug release profile was determined by ELISA study. bioactivity VEGF-incorporated (VEGF-NPs) tube formation assay. A rabbit hind limb ischemia model employed to evaluate in vivo effect. Blood perfusion measured single-photon emission...
Histone deacetylase 9 (HDAC9) is a member of the HDAC gene family that plays essential roles in organization transcriptional regulation by catalyzing deacetylation histone proteins. However, effects HDAC9 on osteonecrosis femoral head (ONFH) have not been investigated. The present study aimed to reveal whether regulated osteogenic differentiation.A lentiviral knockdown model was established hBMSCs. Osteoblast-specific expression, such as Runx2, OCN examined qRT-PCR and Western blot,...
Brassica rapa L. has been widely used as an edible, feeding and medicinal plant in the Qinghai-Tibet Plateau due to its several pharmacological effects of alleviating deficiency or weakness, anti-inflammation, relieving acute mountain sickness. However, therapeutic efficacy underlying mechanism against fatigue have not elucidated. The aim this study is investigate action mechanisms extract (BE) treating fatigue, with emphasis on fatigue-related biomarkers, targets pathways, via network...
Sepsis is a severe inflammatory syndrome with high mortality and morbidity. Sepsis-induced myocardial dysfunction (SIMD) common cause of death in sepsis. The female sex less susceptible to sepsis-related organ dysfunction, although the underlying mechanism this difference remains unclear. This study explored role estrogen receptor G protein-coupled 30 (GPR30) septic cardiac dysfunction. Results from present indicated that GPR30 activation by G1 agonist protected mouse hearts against SIMD...
Abstract α7 neuronal nicotinic acetylcholine receptors (α7nAChRs) are expressed widely in the brain, where they contribute to a variety of behaviors including arousal and cognition, participate number neurodegenerative disorders Alzheimer’s Parkinson’s disease, is responsible for nicotine addiction. Although recent studies indicate that PDZ-containing proteins comprising PSD-95 family co-localize with mediate downstream signaling neurons, mechanisms by which α7nAChRs regulated still less...