Xindi Chen

ORCID: 0000-0003-4400-2908
Publications
Citations
Views
---
Saved
---
About
Contact & Profiles
Research Areas
  • Coastal wetland ecosystem dynamics
  • Coastal and Marine Dynamics
  • Microbial Fuel Cells and Bioremediation
  • Membrane-based Ion Separation Techniques
  • Membrane Separation Technologies
  • Microbial Community Ecology and Physiology
  • Methane Hydrates and Related Phenomena
  • Aeolian processes and effects
  • Geological formations and processes
  • Circular RNAs in diseases
  • Pharmaceutical and Antibiotic Environmental Impacts
  • Electrochemical Analysis and Applications
  • Escherichia coli research studies
  • Salmonella and Campylobacter epidemiology
  • Legionella and Acanthamoeba research
  • MicroRNA in disease regulation
  • Anaerobic Digestion and Biogas Production
  • Inflammatory Bowel Disease
  • Advanced oxidation water treatment
  • Railway Engineering and Dynamics
  • Vibrio bacteria research studies
  • Catalysis for Biomass Conversion
  • Brucella: diagnosis, epidemiology, treatment
  • Ammonia Synthesis and Nitrogen Reduction
  • Oral microbiology and periodontitis research

Sun Yat-sen University
2024-2025

Hohai University
2014-2024

Peking University
2024

Inner Mongolia Agricultural University
2020-2024

Fudan University
2024

State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering
2020-2023

Jilin University
2022-2023

First Hospital of Jilin University
2023

Tsinghua University
2020-2022

Guangdong University of Technology
2020

Under stress conditions, translationally stalled mRNA and associated proteins undergo liquid-liquid phase separation condense into cytoplasmic foci called granules (SGs). Many viruses hijack SGs for their pathogenesis; however, whether pathogenic bacteria also exploit this pathway remains unknown. Here, we report that members of the OspC family Shigella flexneri induce SG formation in infected cells. Mechanistically, effectors target multiple subunits host translation initiation factor 3...

10.1016/j.celrep.2024.113789 article EN cc-by-nc-nd Cell Reports 2024-02-01

The aim of this study was to investigate the metronidazole (MNZ) degradation and real MNZ pharmaceutical wastewater treatment in pulsed switching peroxi-coagulation (PSPC) process. Different frequencies running times H2O2 Fe2+ productions were tested PSPC Results demonstrated that removal 96.9 ± 1.2% realized process with a 200 mg/L 0.1 M Na2SO4 solution within 80 min under frequency 6s: 1s current density 20 mA/cm2 (H2O2) (Fe2+). High could be attributed efficient •OH production highest...

10.1016/j.watcyc.2024.04.002 article EN cc-by-nc-nd Water Cycle 2024-01-01

Haemonchus contortus (H. contortus) is the most common parasitic nematode in ruminants and prevalent worldwide. H. resistance to albendazole (ABZ) hinders efficacy of anthelmintic drugs, but little known about molecular mechanisms that regulate this drug resistance. Recent research has demonstrated long noncoding RNAs (lncRNAs) can exert significant influence as pivotal regulators emergence

10.1186/s12864-024-10096-6 article EN cc-by BMC Genomics 2024-02-17

Xenophagy is an evolutionarily conserved host defensive mechanism to eliminate invading microorganisms through autophagic machinery. The intracellular bacterial pathogen Legionella pneumophila can avoid clearance by the xenophagy pathway via actions of multiple Dot/Icm effector proteins. Previous studies have shown that p62, adaptor protein involved in signaling, excluded from Legionella-containing vacuoles (LCVs). Such defects are attributed multifunctional SidE family effectors (SidEs)...

10.1016/j.celrep.2023.112817 article EN cc-by-nc-nd Cell Reports 2023-07-19

Introduction Haemonchus contortus ( H. ) is a common gastrointestinal nematode in small ruminants, posing significant threat to the livestock industry. The control of often depends on drugs such as albendazole. However, prolonged and improper use these by producers has led widespread resistance among ruminant populations, major challenge parasite management. It reported that albendazole related single nucleotide polymorphism (SNP) β-tubulin homologous type I gene, but whether other genes are...

10.3389/fvets.2025.1567869 article EN cc-by Frontiers in Veterinary Science 2025-05-12

Abstract Biofilm mediated intertidal sediments exhibit more complex erosional behaviour than abiotic systems. A major feature of systems is the exposure to repeated cycles high and low shear created by tidal conditions also less predictable episodic events, such as storms. There very little information on how biofilm‐forming communities respond these conditions. In this study, effects both single repeated‐cycles stability newly developed bio‐sedimentary beds was examined. Cleaned sand,...

10.1002/esp.4573 article EN Earth Surface Processes and Landforms 2019-01-02

New therapeutic strategies for clinical Salmonella enterica serovar Typhimurium (S. Typhimurium) infection are urgently needed due to the generation of antibiotic-resistant bacteria. Inhibition bacterial virulence has been increasingly regarded as a potential and innovative strategy development anti-infection drugs. pathogenicity island (SPI)-encoded type III secretion system (T3SS) represents key factor in S. Typhimurium, active invasion replication host cells is facilitated by T3SS...

10.3389/fcimb.2022.967149 article EN cc-by Frontiers in Cellular and Infection Microbiology 2022-09-13

Abstract Cohesive extracellular polymeric substances (EPS) generated by microorganisms abundant on Earth are regarded as bed “stabilizers” increasing the erosion threshold in sedimentary systems. However, most observations of this phenomenon have been taken under steady flow conditions. In contrast, we present how EPS affect movement wave action, showing a destabilization system. We demonstrate complex behavior biosedimentary deposits, which encompasses liquefaction, mass motion, varying...

10.1029/2020gl092137 article EN Geophysical Research Letters 2021-01-15

Salmonella enterica serovar Typhimurium (S. Typhimurium) is a zoonotic pathogen that can cause food poisoning and diarrhea in both humans animals worldwide. The pathogenicity island (SPI) genes encoded type III secretion system (T3SS) important for S. invasion replication host cells. Due to the increasing problem of antibiotic resistance, treatment clinical infection has gradually been limited. Anti-virulence inhibitors are promising alternative antibiotics because they do not easily induce...

10.3389/fmicb.2021.784926 article EN cc-by Frontiers in Microbiology 2022-01-25

Abstract Sand‐attached benthic biofilms drive many important biogeological processes and serve as cooperative “ecosystem engineers”. In aquatic environments, undergo periodic detachment re‐colonization due to the regular changes in hydrodynamic forcing. However, legacy impacts of past microbial actions on current biofilm formation biostabilization substratum sands are yet be fully understood. this study, a systematic set flume experiments were conducted investigate effects different...

10.1029/2021wr031098 article EN Water Resources Research 2022-03-01

A notable feature of the Deepwater Horizon oil spill was unprecedented formation marine snow (MOS) that observed in large quantities floating on sea surface and subsequently sedimented to seafloor. Whilst physical chemical processes involved MOS remain unclear, some studies have shown extracellular polymeric substances (EPS) play a role this process. Here, we report during exposure subarctic northeast Atlantic seawater dispersant, whether presence/absence crude oil, dispersant stimulates...

10.3389/fmicb.2019.00553 article EN cc-by Frontiers in Microbiology 2019-03-20

Periods of very shallow water (water depth in the order 10 cm) occur daily on tidal flats because propagation tides over gently sloping beds, leading to distinct morphodynamical phenomena. To improve understanding characteristics velocity and suspended sediment concentration (SSC) surges their contribution transport local bed changes during periods water, measurements near-bed flow, SSC were carried out at two cross-shore locations an intertidal flat along Jiangsu coast, China. Furthermore,...

10.3389/fmars.2021.599799 article EN cc-by Frontiers in Marine Science 2021-03-05

In this study, a series of laboratory experiments for the response wave induced clay-sand seabed were carried out to clarify mechanism liquefaction clayey seabed. The conducted in an 80 m long flume. tests, sand-clay beds mixed with various clay contents (CC) from 0.5% 15% and tested given conditions. pore water pressure elevation measured each test. Soil properties tests scanning electron microscope (SEM) on different samples further explore liquefaction. experimental results indicated that...

10.3390/jmse8020066 article EN cc-by Journal of Marine Science and Engineering 2020-01-21

The aim of this study is to explore the feasibility applying bipolar membrane electrodialysis (BMED) treat coal chemical waste salt with different pretreatments organic pollutants. organics content in real reached 0.6 ± 0.1% weight averaged molecular 641 g/mol. Only 26.5% total COD 250 g/L solution could be removed by coagulation pretreatment, resulting no apparent improvement BMED performance. Thermal pretreatment at 850 oC for 3 h completely from salt, efficient control fouling BMED. At...

10.2139/ssrn.4704795 preprint EN 2024-01-01
Coming Soon ...