A5009523114- Neurological diseases and metabolism
- Mitochondrial Function and Pathology
- Genetic Neurodegenerative Diseases
- Neurological Disease Mechanisms and Treatments
- Muscle Physiology and Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Machine Learning in Bioinformatics
- Acne and Rosacea Treatments and Effects
- Adipose Tissue and Metabolism
- Alzheimer's disease research and treatments
- Inflammation biomarkers and pathways
- melanin and skin pigmentation
- Hereditary Neurological Disorders
- Biochemical Analysis and Sensing Techniques
- MicroRNA in disease regulation
- Bioinformatics and Genomic Networks
- GDF15 and Related Biomarkers
Yangzhou University
2021-2023
Growing evidence suggests that hypertension and aging are prominent risk factors for the development of late-onset Alzheimer’s disease (LOAD) by inducement neuroinflammation. Recent study showed neuroinflammation via activated microglia induces reactive astrocytes, termed A1 highly upregulate numerous classical complement cascade genes destructive to neurons in neurodegeneration diseases. Moreover, triggering receptor expressed on myeloid cells 2 (TREM2) is considered as one strongest...
Studies have greatly explored the role of microRNAs (miRNAs) in cerebral ischemia/reperfusion injury (CI/RI). But specific mechanism miR-326-5p CI/RI is still elusive. Hence, this study was to unmask miR-326-5p/signal transducer and activator transcription-3 (STAT3) axis CI/RI. Two models (oxygen glucose deprivation [OGD] primary rat cortical neurons middle artery occlusion [MCAO] Sprague-Dawley rats) were established mimic vitro vivo, respectively. Loss- gain-of function assays performed...
We aimed to investigate the biological mechanism and feature genes of Duchenne muscular dystrophy (DMD) by multi-omics experimental verification strategy.We integrated transcriptomic proteomic methods find differentially expressed mRNAs (DEMs) proteins (DEPs) between DMD Control groups. Weighted gene co-expression network analysis (WGCNA) was then used identify modules highly correlated hub genes. In following steps, immune stromal cells infiltrations were accomplished xCELL algorithm....
Charcot-Marie-Tooth disease(CMT) is a hereditary peripheral neuropathy, characterized by progressive distal hypoesthesia and amyotrophia. CMT an X- linked recessive inheritance pattern. The apoptosis-inducing factor mitochondria associated-1 (AIFM1) the main pathogenic gene of X-linked disease-4 with or without cerebellar ataxia (CMTX4), also known as Cowchock syndrome. In this study, we enrolled family CMTX from southeast region China identified novel AIFM1 variant (NM_004208.3: c.931C>G;...
Hermansky-Pudlak syndrome (HPS) is a rare genetic disorder with an autosomal recessive inherited pattern. It mainly characterized by deficiencies in lysosome-related organelles, such as melanosomes and platelet-dense granules, leads to albinism, visual impairment, nystagmus, bleeding diathesis. A small number of patients will present granulomatous colitis or fatal pulmonary fibrosis. At present, mutations ten known loci (HPS1–11) have been identified be the cause HPS. In this study, we...
Ataxia with oculomotor apraxia type 1 (AOA1) is a rare genetic disorder and inherited in an autosomal recessive manner. It mainly characterized by childhood-onset progressive cerebellar ataxia, dysarthria gait disturbance being the two most common typical manifestations. Axonal sensorimotor peripheral neuropathy, dystonia, chorea, cognitive impairment are associated symptoms, as hypoalbuminemia hypercholesterolemia. Oculomotor (OMA)has been reported to be feature often, although not...