A5100440420- Ubiquitin and proteasome pathways
- DNA Repair Mechanisms
- Regulation of Appetite and Obesity
- Autophagy in Disease and Therapy
- Cancer-related Molecular Pathways
- Biochemical Analysis and Sensing Techniques
- Genetic Syndromes and Imprinting
- Kruppel-like factors research
- Galectins and Cancer Biology
- Genetics and Neurodevelopmental Disorders
- Cerebrospinal fluid and hydrocephalus
- RNA modifications and cancer
- Endoplasmic Reticulum Stress and Disease
- Sirtuins and Resveratrol in Medicine
- Mitochondrial Function and Pathology
- Histone Deacetylase Inhibitors Research
- Nerve injury and regeneration
- Adipose Tissue and Metabolism
- Hippo pathway signaling and YAP/TAZ
- Genetics, Aging, and Longevity in Model Organisms
- melanin and skin pigmentation
- Extracellular vesicles in disease
- Hepatitis C virus research
- Congenital heart defects research
- Lower Extremity Biomechanics and Pathologies
Shanghai East Hospital
2016-2024
Tongji University
2016-2024
Shanghai Tenth People's Hospital
2017-2024
Sichuan University
2021
West China Hospital of Sichuan University
2021
Tongji Hospital
2021
Affiliated Hospital of Jining Medical University
2017-2020
Wenzhou Medical University
2016
BRCA1 regulates multiple cellular pathways that maintain genomic stability including cell cycle checkpoints, DNA repair, protein ubiquitination, chromatin remodelling, transcriptional regulation and apoptosis. Receptor-associated 80 (RAP80) helps recruit to double-strand breaks (DSBs) through the scaffold CCDC98 (Abraxas) facilitates damage response (DDR). However, of RAP80-BRCA1 complex is still unclear. Here we report a deubiquitinase, USP13, DDR by targeting RAP80. Mechanistically, USP13...
Homologous recombination (HR) is one of the major DNA double-strand break (DSB) repair pathways in mammalian cells. Defects HR trigger genomic instability and result cancer predisposition. The defining step homologous strand exchange directed by protein RAD51, which recruited to DSBs BRCA2. However, regulation BRCA2-RAD51 axis remains unclear. Here we report that ubiquitination RAD51 hinders RAD51-BRCA2 interaction, while deubiquitination facilitates binding recruitment thus critical for...
Autophagy is an evolutionarily conserved catabolic process, which plays a vital role in removing misfolded proteins and clearing damaged organelles to maintain internal environment homeostasis. Here, we uncovered the checkpoint kinase 2 (CHK2)-FOXK (FOXK1 FOXK2) axis playing important DNA damage-mediated autophagy at transcriptional regulation layer. Mechanistically, following damage, CHK2 phosphorylates FOXK creates 14-3-3γ binding site, which, turn, traps cytoplasm. Because functions as...
Post-stroke depression (PSD) seriously affects the rehabilitation of nerve function and quality life. However, pathogenesis PSD is still not clear. This study aimed to investigate demographic, clinical, biochemical factors in patients with PSD.Patients an acute ischemic stroke, who met inclusion criteria at Shanghai Tenth People's Hospital from April 2016 September 2016, were recruited for this study. The stroke severity was assessed using National Institutes Health Stroke Scale (NIHSS),...
Abstract DEAD box RNA helicase 17 (DDX17) is a transcriptional regulator of several transcription factors, which more appreciated than its role in metabolism. However, prognostic value and biofunction DDX17 HCC remain unclear. Illuminating the mechanism underlying regulating progression by may contribute to therapeutic strategies. In our study, we report for first time that was overexpressed specimens using The Cancer Genome Atlas (TCGA) immunohistochemistry (IHC) correlated clinical...
The dysregulation of autophagy is related to a variety cardiovascular diseases, such as myocardial ischemia/reperfusion (I/R). Nerve growth factor (NGF) has been shown have therapeutic potential in ischaemic heart injury. In this study, we demonstrate that NGF administration can accelerate autophagic flux and attenuate protein ubiquitination I/R heart. Our results showed could restored function decreased the apoptosis cardiomyocytes which induced by protective effect associated with...
Abstract The human RecQ helicase BLM is involved in the DNA damage response, metabolism, and genetic stability. Loss of function mutations cause instability/cancer predisposition syndrome Bloom syndrome. However, molecular mechanism underlying regulation cancers remains largely elusive. Here, we demonstrate that deubiquitinating enzyme USP37 interacts with deubiquitinates stabilizes BLM, thereby sustaining response (DDR). Mechanistically, double-strand breaks (DSB) promotes ATM...
Abstract DNA damage plays a significant role in the tumorigenesis and progression of disease. Abnormal repair affects therapy prognosis cancer. In this study, it is demonstrated that deubiquitinase USP25 promotes non‐homologous end joining (NHEJ), which turn contributes to chemoresistance It shown deubiquitinates SHLD2 at K64 site, enhances its binding with REV7 NHEJ. Furthermore, deficiency impairs NHEJ‐mediated reduces class switch recombination (CSR) ‐deficient mice. overexpressed subset...
Glioblastoma (GBM), characterized by high morbidity and mortality, is one of the most common lethal diseases worldwide. To identify molecular mechanisms that contribute to development GBM, three cohort profile datasets (GSE50161, GSE90598 GSE104291) were integrated thoroughly analyzed; these included 57 GBM cases 22 normal brain tissue. The current study identified differentially expressed genes (DEGs), analyzed potential candidate pathways. Additionally, a DEGs‑associated protein‑protein...
Abstract This study aimed to investigate the role of deubiquitinating enzyme 3 (DUB3) in regulation Krüppel-like factor 4 (KLF4) expression hepatocellular carcinoma (HCC). Gain- and loss-of-function assay, luciferase reporter co-immunoprecipitation, intracellular extracellular deubiquitination assays were conducted vitro. A tumor xenograft mouse model was established. The DUB3 KLF4 examined HCC patient specimens. results showed that upregulated by stabilizing protein cells through binding...
Abstract Physiological modulation of melanocortin‐4 receptor (MC4R) signaling by MRAP2 proteins plays an indispensable role in appetite control and energy homeostasis the central nervous system. Great interspecies differences interaction regulation melanocortin receptors MRAP protein family have been reported several diploid vertebrates but never investigated tetrapod amphibian Xenopus laevis . Here, we performed phylogenetic synteny‐based analyses to explore evolutionary aspects dual copies...
Abstract A perforating head injury is a type of an wherein the projectile passes entirely through cranium leaving both entrance and exit wounds. It considered less prevalent than other kinds trauma such as closed or penetrating injuries carry worse prognosis among varieties injuries. Having unique mechanism pathophysiology it significant challenge for practicing neurosurgeon mandating high precaution novel approach to minimize further damage. Here, we presented case 5-year-old boy who...
Endoscopic endonasal surgery for pituitary adenomas is being performed more frequently worldwide in the recent years. This first bibliometric analysis was conducted aiming to have a microscopic view of research activities about endoscopic adenomas. The original articles were extracted from Web Science (WoS) and analyzed concerning their distributions. We also explored potential correlations between publications different countries gross domestic product (GDP) via Pearson correlation test....
As a member of the seven-transmembrane rhodopsin-like G protein-coupled receptor superfamily, melanocortin-3 (MC3R) is vital for regulation energy homeostasis and rhythms synchronizing in mammals, its pharmacological effect could be directly influenced by presence melanocortin accessory proteins (MRAPs), MRAP1 MRAP2. The tetrapod amphibian Xenopus laevis (xl) retains higher duplicated genome than extant teleosts serves as an ideal model system embryonic development physiological studies....