A5065601005- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiac Arrest and Resuscitation
- Head and Neck Surgical Oncology
- Intensive Care Unit Cognitive Disorders
- Glioma Diagnosis and Treatment
- Traumatic Brain Injury Research
- Intracranial Aneurysms: Treatment and Complications
- Meningioma and schwannoma management
- Functional Brain Connectivity Studies
- Cardiac Ischemia and Reperfusion
- Pituitary Gland Disorders and Treatments
- Radiomics and Machine Learning in Medical Imaging
- Adrenal and Paraganglionic Tumors
- Thermoregulation and physiological responses
- Electrospun Nanofibers in Biomedical Applications
- Neuropeptides and Animal Physiology
- Cancer Mechanisms and Therapy
- Vitamin C and Antioxidants Research
- S100 Proteins and Annexins
- Cancer Cells and Metastasis
- Thyroid and Parathyroid Surgery
- Extracellular vesicles in disease
- Cleft Lip and Palate Research
- Teratomas and Epidermoid Cysts
- Tissue Engineering and Regenerative Medicine
Shanghai Tenth People's Hospital
2016-2024
Tongji University
2016-2024
East China Normal University
2024
University of Maryland, Baltimore
2020-2022
Qilu Hospital of Shandong University
2015-2021
Shandong University
2013-2015
To assess the effectiveness of continuous lumbar drainage (LD) for management postoperative cerebrospinal fluid leaks after endoscopic endonasal transsphenoidal approach resection pituitary adenoma. Three hundred eighty-four medical records patients who were admitted to our institute during a 2.5-year period retrospectively reviewed, 33 them experienced low-flow leak postoperatively. If LD was used, all with classified into 2 groups, drained group and conservatively treated group. The age,...
Although there are a certain number of studies dedicated to the disturbances dopaminergic system induced by traumatic brain injury (TBI), associations abnormal systems with post-traumatic anxiety and depressive disorders their underlying mechanisms have not been clarified yet. In midbrain, neurons mainly situated in substantia nigra (SN) ventral tegmental area (VTA). Thus, we selected SN VTA as regions interest performed seed-based global correlation evaluate altered functional connectivity...
High-grade glioma is characterized by cell heterogeneity, gene mutations, and poor prognosis. Abnormal copper homeostasis affects the pathogenesis of glioma, but underlying mechanisms involved proteins are unknown. Here, we selected 90 copper-related verified their expression differences in normal tissues TCGA cohort followed GO KEGG clustering analyses. We then developed validated a prognostic model. Moreover, examined mutation burden discussed immune microenvironment high- low-risk groups....
Aim: To study RNA N6-methyladenosine (m6A) modification in the diabetic hippocampus. Methods: Behavioral tests and staining were performed to evaluate damage hippocampus model rats. Western blotting was investigate expression of methylation-related enzymes, flow cytometry used demonstrate HT22 cell apoptosis. M6A sequencing analyses conducted profile m6A-tagged transcripts Results: The rat models diabetes mellitus suffered from cognitive disorders hippocampal neuron damage. High glucose...
To explore the interhemispheric functional coordination following traumatic brain injury (TBI) and its association with posttraumatic anxiety depressive symptoms.This was a combination of retrospective cohort study cross-sectional observational study. We investigated between hemispheres by voxel-mirrored homotopic connectivity (VMHC). Grey matter volumes were examined voxel-based morphometry (VBM), microstructural integrity corpus callosum (CC) assessed diffusion tension imaging (DTI). The...
Memory impairment and mood disorders are among the most troubling sequelae following traumatic brain injury (TBI). The relationships between comorbid psychiatric memory function have not been well illustrated. aim of study was to explore anxiety depressive symptoms with TBI.A total 46 TBI participants across all levels 23 healthy controls were enrolled in this case-control study. Wechsler Scale-Chinese Revision (WMS-CR) picture, recognition, associative learning, comprehension memory, digit...
Clean and fast craniotomy closure (CAC) is a fundamental part of modern microneurosurgery, an essential technique that young neurosurgeons shall master. The hemostatic instruments CAC have evolved from forceps to raney clips. Thanks the wide application bipolar coagulation, local infiltration anesthesia combined with cauterization become effective method hemostasis. authors worked out standard operating procedure (SOP) assisted by fishhooks without According authors' experience, average time...
Endoscopic transsphenoidal surgery is a form of treatment for Cushing's disease that initially preferred compared with other types treatment. Peritumoral tissue inactivated by cauterization if clear border the lesion cannot be identified. In order to compare surgical outcomes and post-operative complications between patients who underwent inactivation (cauterization peritumoral tissues referred as inactivation) those did not, medical records treated January 2010 June 2016 were...
<title>Abstract</title> Traumatic brain injury (TBI) remains a leading cause of mortality and morbidity worldwide. Current clinical treatments often target singular pathological processes, resulting in suboptimal outcomes due to lack comprehensive neuroprotective effects. To address this critical gap, we have developed an innovative therapeutic approach utilizing mesenchymal stromal cell (MSC)-derived exosome (Mexo)-coated albumin nanospheres loaded with Alitretinoin (Ali-NPs@Mexo). This...
Abstract Clean and fast craniotomy closure (CAC) for retrosigmoid approach with safe satisfactory exposure remains our primary goal. A standard operation procedure (SOP) of was developed reviewed. Between January 2015 2017, 97 patients suffering various lesions underwent surgeries using this technique in the Department Neurosurgery, Qilu Hospital Shandong University. The records concerning time craniotomies, blood losses, complications were By applying SOP, a generally took 15 to 35 minutes,...