A5100642236- Renal Transplantation Outcomes and Treatments
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Diabetes Management and Research
- Pituitary Gland Disorders and Treatments
- Diabetes Management and Education
- Salivary Gland Disorders and Functions
- Adrenal and Paraganglionic Tumors
- Inflammatory mediators and NSAID effects
- Autophagy in Disease and Therapy
- Cardiac Health and Mental Health
- Pharmacological Effects of Natural Compounds
- Organ Transplantation Techniques and Outcomes
- Plant-based Medicinal Research
- Pancreatic function and diabetes
- Acute Myocardial Infarction Research
- Ocular Surface and Contact Lens
- Biomedical Ethics and Regulation
- NF-κB Signaling Pathways
- Metabolism, Diabetes, and Cancer
- Cytomegalovirus and herpesvirus research
- Organ Donation and Transplantation
- Transplantation: Methods and Outcomes
- Rheumatoid Arthritis Research and Therapies
- Mesenchymal stem cell research
- Hormonal Regulation and Hypertension
Qilu Hospital of Shandong University
2004-2024
Dalian Medical University
2019-2023
Shandong University
2018-2021
Mayo Clinic in Arizona
2011-2013
Mayo Clinic
2012
Chinese University of Hong Kong
2010-2011
Prince of Wales Hospital
2010
Non-alcoholic fatty liver disease (NAFLD) is a burgeoning health problem and considered as hepatic manifestation of metabolic syndrome. Increasing evidence demonstrates that berberine (BBR), natural plant alkaloid, beneficial for obesity-associated NAFLD. However, the mechanisms about how BBR improves steatosis remain uncertain. Recently, some reports revealed enhanced autophagy could decrease lipid accumulation. In this study, we first established high-fed diet (HFD) mice model...
Epidemiology of cytomegalovirus (CMV) infection has not been comprehensively studied after all three types pancreas transplant (PT) including simultaneous pancreas-kidney transplantation (SPK), alone (PTA), and kidney (PAK).We evaluated incidence, risk factors, outcomes CMV at our center from January 1, 1998, to December 31, 2009.The study cohort included 252 recipients (SPK 60, PTA 71, PAK 121), 53% men, age 43.9±9 years, followed for 6.3 (interquartile range 3-9) years. serostatus was...
Abstract Background Mesenchymal stem cells (MSCs) show promising therapeutic potential in treating type 2 diabetes mellitus (T2DM) clinical studies. Accumulating evidence has suggested that the effects of MSCs are not due to their direct differentiation into functional β-cells but instead mediated by paracrine functions. Among them, exosomes, nano-sized extracellular vesicles, important substances exert However, underlying mechanisms exosomes ameliorating T2DM remain largely unknown. Methods...
Abstract Background: Elevated admission glucose level is a strong predictor of short‐term adverse outcome in patients with acute coronary syndrome (ACS). However, the prognostic value diabetic control (ie, hemoglobin A 1c levels) ACS still undefined. Hypothesis: Hemoglobin may predict ACS. Methods: We conducted retrospective study prospective follow‐up 317 Patients were stratified into 2 groups based on HbA level, checked within 8 weeks index (optimal group, ≤7%; suboptimal >7%). All...
This study aimed to investigate the role of JAK2-STAT3 (Janus kinase 2/signal transducer and activator transcription 3) in periapical disease caused by Enterococcus faecalis, as well correlation between lipoteichoic acid (LTA) E. faecalis activity signaling pathway osteoclast formation.A rat model periodontitis induced was established. Periapical bone resorption confirmed HE staining. The expression JAK2, p-JAK2, STAT3, p-STAT3 assessed with immunohistochemical Osteoclasts were observed...
Purpose. To investigate the effects of Corbrin Capsule (CS-C-Q80), a drug derived from Cordyceps sinensis (Berk.) Sacc., on autoimmune thyroid diseases (AITD). Methods. 44 Patients with Graves's disease (GD) and 56 patients Hashimoto's thyroiditis (HT) were randomly assigned to treatment group (GD-Tx HT-Tx) or control (GD-Ct HT-Ct). The groups given methimazole levothyroxine only while (2.0 g tid) besides same conventional prescriptions as groups. Thyroid hormones, antibodies, T lymphocyte...
Chen, L; Dong, J; Hou, W; X; Sun, M; Zhang, Tang, K; Y; Fu, Y Author Information
Cushing's syndrome (CS) is a clinical characterized by hypercortisolemia.Cyclic (CCS), which exhibits periodic or irregular increasing pattern in cortisol, rare type of syndrome.A 37-yearold man came to our hospital because repeated dizzy spells, weakness and hypercortisolemia lasting two weeks.Endocrinological examinations indicated CCS with intermittent increases cortisol.Enhanced computed tomography (CT) revealed space occupying lesions on the upper lobe left lung, biopsy eventually...
Objective: We evaluate the prevalence, etiology, and outcomes of hypoglycemia requiring emergency medical services (EMS) in patients without diabetes mellitus (non-DM). Methods: reviewed records all ambulance calls for non-DM with blood glucose <70 mg/dl Olmsted County, Minnesota, between January 1, 2003, December 31, 2009. Results: A total 131 (age 51 ± 19 years; 54 % females) made 142 EMS calls, while 10 repeated calls. Causes were critical illness (42; 32%), alcohol polysubstance use...
Endoscopic transsphenoidal surgery is a form of treatment for Cushing's disease that initially preferred compared with other types treatment. Peritumoral tissue inactivated by cauterization if clear border the lesion cannot be identified. In order to compare surgical outcomes and post-operative complications between patients who underwent inactivation (cauterization peritumoral tissues referred as inactivation) those did not, medical records treated January 2010 June 2016 were...
Thyroid hormone resistance syndrome complicated with papillary thyroid cancer is clinically rare.Madelung's disease a rare disorder of lipid metabolism.We analyzed the clinical data case carcinoma and Madelung's disease,performed whole-exon sequencing for patient's peripheral blood samples,and retrospectively relevant literature.This review expected to provide experience diagnosis treatment.
(1) To examine the potential mechanism of Asarum-Angelica drug pair against periodontitis and provide an experimental basis for treatment with herbal medicine. (2) The core components targets in were detected according to network pharmacology methods. Finally, effect on osteogenic differentiation was observed mouse embryonic osteoblast precursor cells. (3) According results pharmacology, there are 10 active ingredients pair, 44 obtained by mapping treatment. Ten ingredients, such as...
A 62year-old man with history of pulmonary tuberculosis was found upon CT scan to have a ground-glassopacity (GGO) in the right lung. Given patient's background, his primary doctor recommended yearly follow lesion. The lesion increased approximately 1 cm size over next eight years, and patient underwent video-assisted thoracoscopic lower lobe resection. Pathologic examination revealed invasive adenocarcinoma lymph node metastasis. This indicates that, even if it grows slowly is less than 2...
Background: The aim of the study is to identify specific causes mortality and pancreas allograft loss three transplantation (PT) types in modern era with ATG induction tacrolimus based triple immunosuppression. Methods: We performed a retrospective review 262 adult patients who received PT at our institution from 01/01/1998 12/31/2009. death graft were determined by reviewing clinical histologic information. Results:89 recipients cohort died during median follow-up 8 years (IQR 4.1 11.2...