A5100395340- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- RNA modifications and cancer
- RNA Interference and Gene Delivery
- PARP inhibition in cancer therapy
- Cell death mechanisms and regulation
- Lung Cancer Treatments and Mutations
- Intestinal Malrotation and Obstruction Disorders
- Osteoarthritis Treatment and Mechanisms
- Extracellular vesicles in disease
- Histone Deacetylase Inhibitors Research
- RNA Research and Splicing
- Pediatric Hepatobiliary Diseases and Treatments
- Gastrointestinal disorders and treatments
Air Force Medical University
2023-2024
State Key Laboratory of Genetic Engineering
2024
Fudan University
2022-2024
Linyi People's Hospital
2017-2024
Long noncoding RNA (lnc ) DLEU 2 has been shown to be dysregulated in several type of tumor. However, the potential biological roles and molecular mechanisms pancreatic cancer ( PC progression are poorly understood. In this study, we found that level was substantially upregulated tissues cell lines, significantly associated with poor clinical outcomes patients. Overexpression induced proliferation invasion, whereas knockdown impaired invasion vitro. Furthermore, bioinformatics analysis,...
Abstract Background Detecting early‐stage lung cancer is critical to reduce the mortality rate; however, existing models based on germline variants perform poorly, and new are needed. This study aimed use extreme gradient boosting develop a predictive model for early diagnosis of in multicenter case–control study. Materials Methods A total 974 cases 1005 controls Shanghai Taizhou were recruited, 61 single nucleotide polymorphisms (SNPs) genotyped. Multivariate logistic regression was used...
The natural compound curcumin has previously been reported to inhibit pancreatic cancer cell growth. However, the underlying molecular mechanisms this effect remain unclear. Results from present study demonstrate that miR‑340/X‑linked inhibitor of apoptosis (XIAP) signaling pathway mediates curcumin‑induced apoptosis. miR‑340 was identified be significantly upregulated following treatment. In addition, treatment with or induced apoptosis, whereas silencing endogenous inhibited proapoptotic...
Osteoarthritis is a degenerative disease characterized by abnormal neurovascularization at the osteochondral junctions, regulatory mechanisms of which remain poorly understood. In present study, murine osteoarthritic model with augmented junction used to examine this under-evaluated facet joint dysfunction. Increased extracellular RNA (exRNA) content identified in neurovascularized joints. It found that amount exRNA positively correlated extent and expression vascular endothelial growth...
Background:The single nucleotide polymorphism (SNP) of Gastrokine-1 (GKN1) is associated with lung cancer but its association prognosis not clear.Methods: Genomic DNA was extracted from the blood samples 888 patients cancer.The between GKN1 rs4254535 and prognostic analyzed by Kaplan-Meier (KM) method, Log-rank test, Cox proportional hazards model. Results:In females diagnosed late-stage cancer, CC genotype (CC vs TT, adjusted odds ratio [HR] = 0.57, 95% Confidence Interval [CI]: 0.33-0.99,P...
Abstract The RNA found in the circular system is known as extracellular (exRNA). This kind of has been to play a biological role similar that messenger. They can be used indicators disease status or physiological health an organism. A large number RNA‐based biomaterials have developed by simulating function and structure natural molecules. structural programmability provides spur for scientists pioneer new approaches detection prevention. Nevertheless, link between exRNA design not fully...