A5101408498- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Pharmacogenetics and Drug Metabolism
- Drug Transport and Resistance Mechanisms
- Liver physiology and pathology
- Genetic Associations and Epidemiology
- MicroRNA in disease regulation
- Glutathione Transferases and Polymorphisms
- Liver Disease Diagnosis and Treatment
- Cancer-related Molecular Pathways
- DNA Repair Mechanisms
- Lung Cancer Treatments and Mutations
- Cancer-related molecular mechanisms research
- Cancer Genomics and Diagnostics
- Colorectal Cancer Treatments and Studies
- Cancer-related gene regulation
- Molecular Biology Techniques and Applications
- Cell death mechanisms and regulation
- Protease and Inhibitor Mechanisms
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Nutrition, Genetics, and Disease
- Organ Transplantation Techniques and Outcomes
- RNA Research and Splicing
- Colorectal Cancer Surgical Treatments
- Colorectal and Anal Carcinomas
Guangdong Provincial Center for Disease Control and Prevention
2025
Southern Medical University
2025
Nanfang Hospital
2025
Fudan University
2011-2024
State Key Laboratory of Genetic Engineering
2011-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2011-2024
Wangjing Hospital of China Academy of Chinese Medical Sciences
2024
Zhongshan Hospital
2024
Shanghai Medical College of Fudan University
2015-2023
Pudong Medical Center
2021-2023
Abstract The etiology of esophageal squamous cell carcinoma (ESCC) has been shown to be associated with genetic and certain environmental factors that produce DNA damage. Base excision repair (BER) genes are responsible for damage caused by reactive oxygen species other electrophiles therefore good candidate susceptibility ESCC. We first screened eight BER new potential functional polymorphisms resequencing 27 samples. then identified genotyped important tagging single nucleotide (SNPs) in a...
Rationale: As the central hallmark of liver fibrosis, transdifferentiation hepatic stellate cells (HSCs), predominant contributor to fibrogenic myofibroblast responsible for extracellular matrix (ECM) deposition, is characterized with transcriptional and epigenetic remodeling. We aimed characterize roles H3K27 methyltransferase EZH2 demethylase JMJD3 identify their effective pathways novel target genes in HSCs activation fibrosis. Methods: In primary HSCs, we analyzed effects pharmacological...
Tumor suppressor p53 is crucial for embryonic implantation through transcriptional up-regulation of uterine leukemia inhibitory factor (LIF). This article reports that and estrogen receptor α were activated in endometrial tissues during to coordinately regulate LIF production. By using human knockin (Hupki) mice carrying a single nucleotide polymorphism (SNP) at codon 72 (arginine/proline), the arginine allele was demonstrated produce higher levels than proline allele. In humans, diversity...
As a central event in liver fibrogenesis, hepatic stellate cell (HSC) transdifferentiation involves loss of regulation by adipogenic transcription factors such as peroxisome proliferator-activated receptor γ; (PPARγ), which is epigenetically silenced during HSC activation. We hypothesized that JMJD1A, an H3K9 demethylase involved metabolism, could regulate PPARγ. In human line, rat primary HSCs, and carbontetrachloride-induced mouse fibrogenesis model, we down-regulated the expression JMJD1A...
Co-stimulatory molecules are imperative for CD8+ T cells to eliminate target cell and maintain sustained cytotoxicity. Despite an advanced understanding of the co-stimulatory deficiency that results in tumor escape, cell-intrinsic mechanisms regulate remain enigmatic, in-depth dissection could facilitate improvement treatment options. To this end, study, we report critical costimulatory molecule CD58, mediated by expression ATF4 cells, impairs formation immunological synapses (IS) leads...
Abstract Background Detecting early‐stage lung cancer is critical to reduce the mortality rate; however, existing models based on germline variants perform poorly, and new are needed. This study aimed use extreme gradient boosting develop a predictive model for early diagnosis of in multicenter case–control study. Materials Methods A total 974 cases 1005 controls Shanghai Taizhou were recruited, 61 single nucleotide polymorphisms (SNPs) genotyped. Multivariate logistic regression was used...
The human CYP3A gene cluster codes for cytochrome P450 (CYP) subfamily enzymes that catalyze the metabolism of various exogenous and endogenous chemicals is an obvious candidate evolutionary environmental genomic study. Functional variants in locus may have undergone a selective sweep response to conditions.The goal this study was profile allelic structure across investigate natural selection on locus.From spanning 231 kb, we resequenced 54 DNA fragments (a total 43,675 bases) four genes...
Abstract Background Liver fibrosis is a middle stage in the course of chronic Hepatitis B virus (HBV) infection, which will develop into cirrhosis and eventually hepatocellular carcinoma (HCC) if not treated at early stage. Considering limitations patients' reluctance to undergo liver biopsy, reliable, noninvasive diagnostic system predict assess treatment prognosis needed. The aim this study was identify biomarkers for diagnosis HBV related fibrosis. Method Plasma samples from 7 healthy...
Tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NKK) is a well defined carcinogen that can induce lung cancer. Genetic polymorphisms in its disposition pathways could modify the risk of developing The authors this report previously catalogued sequence variations adenosine triphosphate-binding cassette B1 (ABCB1) and ABCC1 candidate transporter genes for export Chinese population screened out common variants with potential function their 5' flanking 3'...
Aflatoxin B1 exposure is one of the major risk factors for hepatocellular carcinoma (HCC). CYP1A2 a cytochrome P450 isoenzyme that plays an important role in bioactivation AFB1 to its carcinogenic metabolite. The study was designed assess whether genetic polymorphisms are associated with HCC susceptibility high-risk region.A case-control 431 cases and 550 cancer-free controls recruited from endemic region China carried out. Three single nucleotide polymorphisms, namely -3860G > A...
Inhaled xenobiotics such as tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone are mainly metabolized by phase I oxidase cytochrome P450, family 2, subfamily A, polypeptide 13 (CYP2A13), II conjugate UDP glucuronosyltransferase 2 family, B17 (UGT2B17), and III transporter ATP-binding cassette, B (MDR/TAP), member 1 (ABCB1), with genetic polymorphisms implicated in lung cancer. Their interaction pulmonary expression regulation largely unknown. We analyzed joint...
SLC31A1 is the major transporter for platinum drug intake, its expression correlates with disposition and response. In 1004 Chinese NSCLC patients platinum-based chemotherapy, we investigated association between polymorphisms clinical outcomes. Heterozygotes of rs10759637 at 3'UTR was associated severe thrombocytopenia (odds ratio [OR]: 2.69; P = 0.012) shorter overall survival (hazard [HR]: 1.24; 0.005). Variant homozygote rs2233914 correlated longer 0.73; 0.008). Haplotype diplotype these...
Objective:The expression and function of platinum transporters affect drug tissue concentration therapeutic effects.We had previously characterized functional variant intake transporter SLC31A1 gene.We aimed to investigate the association efflux gene ABCG2 polymorphism combined polymorphisms with clinical outcomes NSCLC patients receiving platinum-based chemotherapy.Methods: We genotyped thirteen tagging SNPs in 1004 patients, assessed their response, toxicity survival using unconditional...
The etiology of esophageal squamous cell carcinoma (ESCC) has been shown to be multifactorial, including genetic, epigenetic, and environmental factors, such as tobacco smoking. A variable number tandem repeats (VNTR) polymorphism in the promoter region SMYD3 , a recently characterized histone lysine methyltransferase gene that is implicated proliferation carcinogenesis, functional, but its association with cancer risk not well established because apparently discrepant results different...
Abstract Caspase-8 and caspase-10 play crucial roles in both cancer development chemotherapy efficacy. In this study, we aimed to comprehensively assess single nucleotide polymorphisms (SNPs) of the caspase-8 (CASP8) (CASP10) genes relation toxicity outcomes with first-line platinum-based patients advanced non-small cell lung (NSCLC). We genotyped 13 tag SNPs CASP8 CASP10 663 NSCLC treated regimens. Associations between were identified a discovery set 279 then validated an independent 384...
RNA preparations contaminated with genomic DNA (gDNA) are frequently disregarded by RNA-seq studies. Such contamination may generate false results; however, their effect on the outcomes of analyses is unknown. To address this gap in our knowledge, here we added different concentrations gDNA to total and subjected them analysis.We found that contaminating altered quantification transcripts at relatively high concentrations. Differentially expressed genes (DEGs) resulting from therefore...
Summary Information about linkage disequilibrium (LD) patterns and haplotype structures for candidate genes is instructive the design analysis of genetic association studies complex diseases drug response. ABCC1 ABCG2 are coding two multidrug resistance (MDR) associated transporters; they also related to some pathophysiological traits. To pinpoint LD profiles these MDR in Chinese, we systemically screened 27 unrelated individuals single nucleotide polymorphisms (SNPs) regulatory regions...
Background As a major mediator in the complex interplay between humans and xenobiotic environment, ABCBI transporter gene is an obvious candidate for comparative evolutionary pharmacogenetic studies. It has been recently reported that common variants its coding region, which are variously associated with drug response disease susceptibility, may have conferred differential selective sweep various populations. Fully profiling alletic architecture explicitly interrogating natural selection at...
Genetic polymorphisms in the signalling pathway of estrogen receptor (ER) could modify risk breast cancer. A variable number tandem repeats (VNTR) polymorphism promoter PTTG1IP, pituitary tumor transforming gene binding factor targeted by α (ERα) endocrine neoplasia, has been shown to be functional, but its relevance cancer etiology was unknown. We investigated association with genotyping 658 patients and 866 controls further analysed differential interaction ERα. found nine types alleles...