A5101717547- Liver Disease Diagnosis and Treatment
- Liver physiology and pathology
- Hepatitis B Virus Studies
- Liver Diseases and Immunity
- Hepatitis C virus research
- Helicobacter pylori-related gastroenterology studies
- Drug-Induced Hepatotoxicity and Protection
- Pharmacological Effects of Natural Compounds
- Traditional Chinese Medicine Studies
- Protein Structure and Dynamics
- Liver Disease and Transplantation
- Protein Kinase Regulation and GTPase Signaling
- Gastroesophageal reflux and treatments
- Inflammatory mediators and NSAID effects
- Immune Response and Inflammation
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- Folate and B Vitamins Research
- Advanced Glycation End Products research
- Cellular transport and secretion
- Macrophage Migration Inhibitory Factor
- Metabolism and Genetic Disorders
- Eicosanoids and Hypertension Pharmacology
- Traditional Chinese Medicine Analysis
- Gallbladder and Bile Duct Disorders
Hong Kong University of Science and Technology
2024
University of Hong Kong
2024
Sun Yat-sen University
2008-2022
Fudan University
2010-2022
Zhongshan Hospital
2008-2022
The First Affiliated Hospital, Sun Yat-sen University
2008-2022
State Key Laboratory of Genetic Engineering
2022
Wenzhou Medical University
2022
First Affiliated Hospital of Wenzhou Medical University
2022
Blood Center of Zhejiang Province
2022
Helicobacter pylori ( H. ) infection is an infectious disease with a prevalence rate of up to 50% worldwide. It can cause indigestion, gastritis, peptic ulcer, and gastric cancer. eradication treatment effectively control progression reduce the risk above conditions. However, escalating trend antibiotic resistance presents global challenge for eradication. We aim provide guidance on pharmacological infection.
A peptide corresponding to the basic (+13), unstructured effector domain of myristoylated alanine-rich C kinase substrate (MARCKS) binds strongly membranes containing phosphatidylinositol 4,5-bisphosphate (PIP2). Although aromatic residues contribute binding, three experiments suggest binding is driven mainly by nonspecific local electrostatic interactions. First, peptides with 13 residues, Lys-13 and Arg-13, bind PIP2-containing vesicles same high affinity as peptide. Second, removing from...
Emerging evidences exhibit that mitogen-activated protein kinase (MAPK/MPK) signaling pathways are connected with many aspects of plant development. The complexity MAPK cascades raises challenges not only to identify the module in planta but also define specific role an individual module. So far, our knowledge has been largely restricted a small subset cascades. Our previous study characterized Arabidopsis bushy and dwarf1 (bud1) mutant, which MAP Kinase 7 (MKK7) was constitutively...
Background Hepatitis B virus-related liver fibrosis (HBV-LF) always progresses from inflammation to fibrosis. However, the relationship between these two pathological conditions is not fully understood. Here, it postulated that balance regulatory T (Treg) cells and helper 17 (Th17) as an indicator of may predict progression HBV-LF. Methodology/Principal Findings The frequencies phenotypes peripheral Treg Th17 seventy-seven HBeAg-positive chronic hepatitis (CHB) patients who underwent...
Both the myristoylated alanine-rich protein kinase C substrate (MARCKS) and a peptide corresponding to its basic effector domain, MARCKS-(151-175), inhibit phosphoinositide-specific phospholipase (PLC)-catalyzed hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP(2)) in vesicles (Glaser, M., Wanaski, S., Buser, C. A., Boguslavsky, V., Rashidzada, W., Morris, Rebecchi, Scarlata, S. F., Runnels, L. Prestwich, G. D., Chen, J., Aderem, Ahn, McLaughlin, (1996) J. Biol. Chem. 271,...
We have studied the binding of peptides containing both basic and aromatic residues to phospholipid vesicles. The caveolin(92−101) MARCKS(151−175) contain five residues, but 3 13 positive charges, respectively. Our results show insert into bilayer anchor weakly vesicles formed from zwitterionic lipid phosphatidylcholine (PC). Incorporation a monovalent acidic (e.g., phosphatidylserine, PS) enhances via nonspecific electrostatic interactions. As predicted application Poisson−Boltzmann...
Background The migration of hepatic stellate cells (HSCs) is essential to the fibrotic response, and recently High-mobility group box 1 (HMGB1) has been shown up-regulated during liver fibrosis. Nevertheless, whether HMGB1 can modulate proliferation HSCs poorly understood, as well involved intracellular signaling. In this study, we examined effect on proliferation, migration, pro-fibrotic function investigated toll-like family receptor 4 (TLR4) dependent signal pathway in signaling...
Acupuncture is the most widely used traditional and complementary medicine, in 113 of 120 countries according to a 2019 World Health Organization report. 3In addition registered acupuncturists, medical doctors, nurse practitioners, chiropractors occasionally deliver acupuncture treatment. 4Despite its widespread use considerable available evidence, until recently, clinical practice guidelines from conventional organisations rarely included recommendations on acupuncture.Clinical aim optimise...
Type 3 innate lymphoid cell (ILC3) has recently emerged as a crucial effector in inflammatory and fibrotic diseases. The present study was designed to determine the roles of ILC3 liver fibrosis. By flow cytometry, we documented increased frequencies peripheral (Lin−CD127+CD117+CD294− lymphocytes) patients, especially at advanced stage hepatitis B virus (HBV)-related chronic diseases, demonstrated their correlations with disease progression. vitro fibrogenic effects by were determined...
Membrane binding of the myristoylated alanine-rich C kinase substrate (MARCKS) requires both its myristate chain and basic 舠effector舡 region. Previous studies with a peptide corresponding to effector region, MARCKS-(151–175), showed that 13 residues interact electrostatically acidic lipids 5 hydrophobic phenylalanine penetrate polar head group region bilayer. Here we describe kinetics membrane fluorescent (acrylodan-labeled) peptides measured stopped-flow technique. Even though penetrates...
ABSTRACT— Aims/Background: Potenlini is an injectable compound whose active component glycyrrhizin, which extracted from licorice. Previous studies showed that it could reduce liver injury, improve alanine aminotransferase (ALT) levels and act as antifibrotic agent. However, the mechanism of its action remains unclear. The aim this study was to determine molecular by investigating effects potenlini on nuclear factor‐κB(NF‐κB) binding activity in animal model cirrhosis. Methods: Rats were...
Abstract Background Liver fibrosis is a middle stage in the course of chronic Hepatitis B virus (HBV) infection, which will develop into cirrhosis and eventually hepatocellular carcinoma (HCC) if not treated at early stage. Considering limitations patients' reluctance to undergo liver biopsy, reliable, noninvasive diagnostic system predict assess treatment prognosis needed. The aim this study was identify biomarkers for diagnosis HBV related fibrosis. Method Plasma samples from 7 healthy...
Shear stress imposed by blood flow is crucial for differentiation of endothelial progenitor cells (EPCs). Histone deacetylase SIRT1 has been shown to play a pivotal role in many physiological processes. However, association expression with shear stress-induced EPC remains be elucidated. The present study was designed determine the effect on induced stress, and seek underlying mechanisms. Human umbilical cord blood-derived EPCs were exposed laminar 15 dyn/cm(2) parallel plate chamber system....
Aim: Tauroursodeoxycholic acid (TUDCA) is a taurine conjugated form of ursodeoxycholic (UDCA) with higher hydrophility. To further evaluate the efficacy and safety TUDCA for primary biliary cholangitis (PBC), we performed this study on Chinese patients. Methods: 199 PBC patients were randomly assigned to either 250 mg plus UDCA placebo or placebo, 3 times per day 24 weeks. The endpoint was defined as percentage achieving serum alkaline phosphatase (ALP) reduction more than 25% from baseline....
Chrysanthemum flower is a common traditional Chinese medicine (TCM). In this work, pressurized hot water extraction (PHWE) followed by headspace solid-phase microextraction (HS-SPME) and GC-MS was developed for the determination of three main active volatile compounds eucalyptol, camphor, borneol in flowers from four different growing areas China internal standard method. The parameters PHWE HS-SPME were optimized. method also validated. results showed that PHWE-SPME-GC-MS simple, rapid,...