A5034630000- RNA Research and Splicing
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Mitochondrial Function and Pathology
- Ginseng Biological Effects and Applications
- Cancer, Stress, Anesthesia, and Immune Response
- Cellular Mechanics and Interactions
- Extracellular vesicles in disease
- Nuclear Structure and Function
- Cardiac Ischemia and Reperfusion
- Cancer-related molecular mechanisms research
- Protein Kinase Regulation and GTPase Signaling
- Histone Deacetylase Inhibitors Research
- Anesthesia and Neurotoxicity Research
- Pluripotent Stem Cells Research
- RNA Interference and Gene Delivery
- Sirtuins and Resveratrol in Medicine
- Caveolin-1 and cellular processes
Shanghai Jiao Tong University
2010-2020
Beihang University
2019
Beijing Advanced Sciences and Innovation Center
2019
Huazhong University of Science and Technology
2014
Shaanxi Provincial People's Hospital
2014
Tongji Hospital
2014
Shanxi Medical University
2014
Endothelial cells (ECs) are located at the interface between flowing blood and vessel wall, abnormal EC proliferation induced by pathologic environments plays an important role in vascular remodeling hypertensive conditions. Exchanges of information components ECs for function. Hence, present study sought to determine how platelets induce dysfunction under was increased renal rats established abdominal aortic coarctation compared with control that elevated thrombin plasma promoted platelet...
Abstract Cyclic strain is an important inducer of proliferation and migration vascular smooth muscle cells (VSMCs) which are involved in remodeling during hypertension. However, its mechanism remains to be elucidated. VSMCs rat aorta were exposed cyclic strains vitro with defined parameters, the static, 5%‐strain (physiological) 15%‐strain (pathological), at 1.25 Hz for 24 h respectively. Then possible signaling molecules participated strain‐induced VSMC investigated. The results showed that...
Shear stress imposed by blood flow is crucial for differentiation of endothelial progenitor cells (EPCs). Histone deacetylase SIRT1 has been shown to play a pivotal role in many physiological processes. However, association expression with shear stress-induced EPC remains be elucidated. The present study was designed determine the effect on induced stress, and seek underlying mechanisms. Human umbilical cord blood-derived EPCs were exposed laminar 15 dyn/cm(2) parallel plate chamber system....
Abstract Aim Apoptosis of vascular smooth muscle cells (VSMCs) influenced by abnormal cyclic stretch is crucial for remodelling during hypertension. Lamin A/C, a nuclear envelope protein, mechano‐responsive, but the role lamin A/C in VSMC apoptosis still unclear. Methods FX‐5000T Strain Unit provided (CS) vitro. AnnexinV/PI and cleaved Caspase 3 ELISA detected apoptosis. qPCR was used to investigate expression miR‐124‐3p luciferase reporter assay evaluate ability binding Lmna 3’UTR. Protein...
Abstract Abnormal migration and proliferation of vascular smooth muscle cells (VSMCs) are the pathological basis hyperplasia during vein graft disease. It remains unknown if circular RNAs (circRNAs) involved in In present study, a rat model was constructed by “cuff” technique, whole transcriptome deep sequencing applied to identify differential circRNAs grafted compared control. We identified novel circRNA, named circTET3, whose structure verified Sanger RNase R digestion. CircTET3 increased...
This study investigated cadherin-1 (Cdh1) expression in the sensorimotor cortex of rats after spinal cord injury (SCI).The repairing effect Cdh1 was evaluated by silencing its with lentivirus-mediated RNAi.Twenty male Sprague-Dawley (SD) were randomly divided into a normal group and an operation group.Rats given SCI Allen method (T10-T11).Cdh1 examined quantitative real-time polymerase chain reaction (PCR) Western blot analysis.Thirty SD sham-operation (SO) group, lentivirus vector (LV)...
To explore the specific mechanism of sevoflurane in alleviating cerebral ischemia-reperfusion injury (CIRI) rats through c-Jun N-terminal kinase (JNK) signaling pathway.A total 60 male pathogen-free Sprague-Dawley were randomly divided into sham group (n=20), model and (n=20). In group, (2.5%) was inhaled for min at 24 h before blockage blood supply. The CIRI established using suture method while right common carotid artery external separated ligated only, without placement, group. At after...