A5025895177- Cancer, Hypoxia, and Metabolism
- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Pluripotent Stem Cells Research
- Angiogenesis and VEGF in Cancer
- Receptor Mechanisms and Signaling
- Renal cell carcinoma treatment
- COVID-19 Clinical Research Studies
- Sodium Intake and Health
- Phagocytosis and Immune Regulation
- Erythropoietin and Anemia Treatment
- Ovarian function and disorders
- Carcinogens and Genotoxicity Assessment
- Long-Term Effects of COVID-19
- Platelet Disorders and Treatments
- Histone Deacetylase Inhibitors Research
- Endoplasmic Reticulum Stress and Disease
- Dialysis and Renal Disease Management
- Barrier Structure and Function Studies
- Maternal and fetal healthcare
- Pharmacological Receptor Mechanisms and Effects
- Nitric Oxide and Endothelin Effects
- Ovarian cancer diagnosis and treatment
- Inflammasome and immune disorders
- Chronic Kidney Disease and Diabetes
Shandong Provincial Hospital
2021-2024
Shandong University
2021-2024
Shandong First Medical University
2021-2024
Shanghai Jiao Tong University
2012-2024
Jilin University
2015
Beth Israel Deaconess Medical Center
2005-2010
Harvard University
2006-2010
University College London
2003
Huazhong University of Science and Technology
2002
National University of Singapore
1995
Acute respiratory distress syndrome (ARDS) is a devastating complication of numerous underlying conditions, most notably sepsis. Although pathologic vascular leak has been implicated in the pathogenesis ARDS and sepsis-associated lung injury, mechanisms promoting are incompletely understood. Angiopoietin-2 (Ang-2), known antagonist endothelial Tie-2 receptor, was originally described as naturally occurring disruptor normal embryonic development otherwise mediated by agonist angiopoietin-1...
Erythropoietin is a growth factor commonly used to manage anemia in patients with chronic kidney disease. A significant clinical challenge relative resistance erythropoietin, which leads use of successively higher erythropoietin doses, failure achieve target hemoglobin levels, and increased risk adverse outcomes. acts through the receptor (EpoR) present erythroblasts. Alternative mRNA splicing produces soluble form EpoR (sEpoR) found human blood, however its role not known.
Shear stress imposed by blood flow is crucial for differentiation of endothelial progenitor cells (EPCs). Histone deacetylase SIRT1 has been shown to play a pivotal role in many physiological processes. However, association expression with shear stress-induced EPC remains be elucidated. The present study was designed determine the effect on induced stress, and seek underlying mechanisms. Human umbilical cord blood-derived EPCs were exposed laminar 15 dyn/cm(2) parallel plate chamber system....
The longitudinal multi-omics cohort of patients with acute coronary syndrome (LM-ACS) is designed as a real-world prospective ACS requiring angiography. This study aims to enroll 50,000 participants, thorough collection phenotypic data and analyses performed on biological samples. Additionally, long-term follow-up will be conducted track the incidence major adverse cardiovascular events (MACEs) over participants' lifetimes. For this purpose, three scenarios have been established for...
The aging process profoundly impacts the systemic milieu, with specific blood-borne factors playing critical roles in its regulation. Platelet Factor 4 (PF4), released by platelets, has emerged as a novel factor that contributes to rejuvenation of brains rodents. However, age-related disparity PF4 levels humans remains poorly understood. To explore relationship between and natural humans, we collected peripheral blood (PB) samples from young (23.40 ± 2.13 years, n = 15) elderly (75.23 4.19...
Abstract The Severe Acute Respiratory Syndrome (SARS)-CoV-2-induced Coronavirus Disease 2019 (COVID-19) pandemic has caused an overwhelming influence on public health because of its high morbidity and mortality. Critical-illness cases often manifest as acute respiratory distress syndrome (ARDS). Previous evidence suggested platelets thrombotic events key mediators SARS-CoV-2-associated ARDS. However, how the balance platelet regeneration from hematopoietic system is changed in ARDS remains...
The large-scale production of human pluripotent stem cells (hPSCs), including both embryonic (hESCs) and induced (hiPSCs), shows potential for advancing the translational realization hPSC technology. Among multiple cell culture methods, suspension culture, also known as three-dimensional (3D) stands out a promising method to fulfill requirements. Under this 3D condition, expansion preservation pluripotency identity during long-term heavily relies on medium. However, xenogeneic supplements in...
Abstract Background Knowledge about the disease and treatment options is necessary for active patient engagement in shared decision-making, which essential ’patient-centered’ atrial fibrillation (AF) management. Purpose To evaluate knowledge level identify unmet needs of patients with AF China. Methods A nationwide cross-sectional survey was conducted using online or paper questionnaires between May August 2022. Adult outpatients inpatients China were eligible participation. The included...