A5103213020- Reproductive tract infections research
- Dental materials and restorations
- Hepatitis C virus research
- Cervical Cancer and HPV Research
- Urinary Tract Infections Management
- HIV/AIDS drug development and treatment
- Bone Tissue Engineering Materials
- Bone and Dental Protein Studies
- Dental Erosion and Treatment
- Animal Virus Infections Studies
- Virus-based gene therapy research
- Hepatitis B Virus Studies
- Viral gastroenteritis research and epidemiology
- Plant Surface Properties and Treatments
- Consumer Market Behavior and Pricing
- X-ray Diffraction in Crystallography
- Ocular Surface and Contact Lens
- Probiotics and Fermented Foods
- Corneal Surgery and Treatments
- Fluid Dynamics and Heat Transfer
- Antifungal resistance and susceptibility
- Advanced Nanomaterials in Catalysis
- Immune Response and Inflammation
- Advanced biosensing and bioanalysis techniques
- Crystallization and Solubility Studies
Shihezi University
2025
Chengdu Institute of Biology
2025
University of Chinese Academy of Sciences
2025
Xuzhou Central Hospital
2024-2025
Huazhong Agricultural University
2022-2025
Xuzhou Medical College
2022-2024
Sun Yat-sen University
2020-2024
Center of Hubei Cooperative Innovation for Emissions Trading System
2022-2024
Zhejiang University
2014-2023
University of South China
2008-2023
The Toll-mediated signaling cascade using the NF-kappaB pathway has been shown to be essential for immune responses in adult Drosophila, and we recently reported that a human homolog of Drosophila Toll protein induces various response genes via this pathway. We now demonstrate by receptor employs an adaptor protein, MyD88, activation Pelle-like kinase IRAK TRAF6 similar IL-1R-mediated activation. However, find IL-1R pathways are not identical with respect AP-1 Finally, our findings implicate...
ABSTRACT Asunaprevir (ASV; BMS-650032) is a hepatitis C virus (HCV) NS3 protease inhibitor that has demonstrated efficacy in patients chronically infected with HCV genotype 1 when combined alfa interferon and/or the NS5A replication complex daclatasvir. ASV competitively binds to NS3/4A complex, K i values of 0.4 and 0.24 nM against recombinant enzymes representing genotypes 1a (H77) 1b (J4L6S), respectively. Selectivity was by absence any significant activity closely related GB virus-B...
ABSTRACT Although the Chlamydia trachomatis genome is predicted to encode 50 inclusion membrane proteins, only 18 have been experimentally localized in of C. -infected cells. Using fusion proteins and anti-fusion protein antibodies, we systematically evaluated all putative for their localization infected cells, distribution patterns, effects on subsequent chlamydial infection when expressed ectopically, as well immunogenicity during humans. Twenty-two were membrane, 7 detected inside...
Hydrogen sulfide (H2S) is important for normal neural functions, which involves protecting neurons from oxidative stress and neuronal transmission modulation in brain. The detection of H2S significant revealing its role the diagnosis various disease. In this study, a novel multicolor colorimetric assay based on etching gold nanorods (Au NRs) proposed to evaluate level with naked eye. This measurement relies catalytic oxidation 3,3′,5,5′-tetramethylbenzidine (TMB) via horseradish peroxidase...
Hydrosalpinx induction in mice by Chlamydia muridarum infection, a model that has been used to study C. trachomatis pathogenesis women, is known depend on the cryptic plasmid encodes eight genes designated pgp1 pgp8. To identify plasmid-encoded pathogenic determinants, we evaluated transformants deficient plasmid-borne gene pgp3, -4, or -7 for of hydrosalpinx. with an in-frame deletion either pgp3 -4 but not failed induce The mutant phenotype was reproduced using premature termination codon...
ABSTRACT Asunaprevir (BMS-650032) is a potent hepatitis C virus (HCV) NS3 protease inhibitor demonstrating efficacy in alfa interferon-sparing, direct-acting antiviral dual-combination regimens (together with the NS5A replication complex daclatasvir) patients chronically infected HCV genotype 1b. Here, we describe comprehensive vitro genotypic and phenotypic analysis of asunaprevir-associated resistance against genotypes 1a 1b using replicons patient samples obtained from clinical studies...
The discovery of asunaprevir (BMS-650032, 24) is described. This tripeptidic acylsulfonamide inhibitor the NS3/4A enzyme currently in phase III clinical trials for treatment hepatitis C virus infection. 24 was enabled by employing an isolated rabbit heart model to screen cardiovascular (CV) liabilities (changes HR and SNRT) that were responsible discontinuation earlier lead from this chemical series, BMS-605339 (1), trials. structure–activity relationships (SARs) developed with respect CV...
The instability and insolubility of perovskite quantum dots in aqueous solution prohibit applications polar solvents. As a highly toxic gas pollutant also an endogenous gaseous signaling molecule existing variety physiological processes, hydrogen sulfide (H2S), with high selectivity specificity, detection is great significance. In this study, simple device has been designed to separate H2S from CsPbBr3 (CsPbBr3 QDs) have used as the probe develop novel fluorescent sensor for rapid detection....
Summary Background Coronavirus Disease 2019 (COVID-19) caused by Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a global threat to public health. Aiming construct an efficient screening pattern, we comprehensively evaluated the performances of RT-PCR and chest CT in diagnosing COVID-19. Methods The records including demographics, RT-PCR, from 87 confirmed COVID-19 cases 481 exclusion were collected. diagnostic accuracy pharyngeal swab CT, combination with second or...
Relaxor ferroelectric ceramics have very high dielectric constant (<i>ε</i><sub>r</sub>) but relatively low electrical breakdown strength (<i>E</i><sub>b</sub>), while glass–ceramics exhibit higher <i>E</i><sub>b</sub> due to the more uniformly dispersed amorphous phases and submicrocrystals/nanocrystals inside. How effectively combine advantages of both relaxor is great significance for development new materials with energy storage performance. In this work, we firstly prepared...
The discovery of BMS-605339 (35), a tripeptidic inhibitor the NS3/4A enzyme, is described. This compound incorporates cyclopropylacylsulfonamide moiety that was designed to improve potency carboxylic acid prototypes through introduction favorable nonbonding interactions within S1′ site protease. identification 35 enabled optimization and balance critical properties including pharmacokinetics (PK). achieved modulation P2* subsite which identified isoquinoline ring system as key template for...
Abstract MDR1 is highly expressed in MDR A2780DX5 ovarian cancer cells, SGC7901R gastric cells and recurrent tumours. It pumps cytoplasmic agents out of leading to decreased drug accumulation making susceptible multidrug resistance. Here, we identified that miR‐495 was predicted target ABCB1 , which encodes protein MDR1. To reduce the efflux reverse overexpressed a mimic A2780DX transplanted tumours vivo . The results indicated expression above or suppressed subsequently decreased, cell...
The decalcified dentin layer was remineralized in two days using the cooperative effect of PAA and Glu.
ABSTRACT Although modern Chlamydia muridarum has been passaged for decades, there are no reports on the consequences of serial passage with strong selection pressure its fitness. In order to explore potential Pasteurian induce genomic and phenotypic perturbations C. , a starter population was in cultured cells 28 generations without standard infection assistance. The resultant population, designated CMG28, displays markedly reduced vitro dependence centrifugation low incidence severity upper...
Understanding urban spatial pattern of land use is great significance to management and resource allocation. Urban space has strong heterogeneity, thus there were many researches focusing on the identification use. The emergence multiple new types geospatial data provide an opportunity investigate methods mapping essential popularization street view images represented by Baidu Maps benificial rapid acquisition high-precision data, which attracted attention scholars in field research. In this...
It is currently known that crosslinking agents can effectively improve the mechanical properties of dentin by type I collagen. However, few scholars have focused on influence collagen-mineral interface after crosslinking. Analysis Fourier transform infrared spectroscopy (FTIR) results showed hydrogen bonding occurs between tannic acid (TA) molecule and The degree TA to collagen reached a maximum 41.28 ± 1.52. This study used crosslinked fibers successfully induce biomineralization, complete...
Cotton linter black liquor (CPBL) is one of the main pollutants in cotton pulping industry. Due to its high color, pH value, and poor biodegradability, traditional treatment processes have significant limitations terms low efficiency, cost, complex operation. This study used composite natural minerals as raw materials prepare an optimized mineral adsorbent (OCMA) that can effectively remove COD ammonia nitrogen from water while achieving color removal. The was analyzed before after...
Abstract Background Forage quality is a fundamental determinant for livestock productivity in natural grasslands, and sensitive to the variations climate, soil, plant community composition. However, contributions of those factors regional variation forage largely remain unclear. We examined 45 alpine meadow communities over 23.6 × 10 4 km 2 area on eastern Qinghai-Tibet Plateau China. also drivers multiple indicators across scale. Results The results showed that grasslands this region had...
Pinellia ternata (Thunb.) Breit is a widely used medicinal herb in Traditional Chinese Medicine (TCM). Still, its sustainable cultivation threatened by continuous cropping obstacles, which disrupt soil ecosystems, reduce yield, and degrade quality. Objectives: This study explores the potential of microbial inoculants to mitigate these challenges through integrated metabolomic transcriptomic analyses. Methods: Soil samples from fields with without issues were compare effects on secondary...