A5024844345- Animal Virus Infections Studies
- Viral gastroenteritis research and epidemiology
- Virus-based gene therapy research
- Plant Molecular Biology Research
- Corrosion Behavior and Inhibition
- Hydrogen embrittlement and corrosion behaviors in metals
- Plant Reproductive Biology
- Bacterial Genetics and Biotechnology
- Polysaccharides and Plant Cell Walls
- Plant Gene Expression Analysis
- RNA and protein synthesis mechanisms
- Metal-Catalyzed Oxygenation Mechanisms
- Health disparities and outcomes
- Healthcare Systems and Reforms
- Frailty in Older Adults
- Genetic Mapping and Diversity in Plants and Animals
- SARS-CoV-2 and COVID-19 Research
- Plant Stress Responses and Tolerance
- Bioactive Compounds and Antitumor Agents
- Concrete Corrosion and Durability
- Phytochemical compounds biological activities
- Plant-derived Lignans Synthesis and Bioactivity
- Genomics, phytochemicals, and oxidative stress
- Bioactive natural compounds
- Leaf Properties and Growth Measurement
Rice Research Institute
2021-2025
Huazhong Agricultural University
2021-2025
Southwest University
2021-2025
Ningxia Medical University
2020-2024
Donghua University
2024
Center of Hubei Cooperative Innovation for Emissions Trading System
2022-2024
Yunnan University of Traditional Chinese Medicine
2021-2023
People's Hospital of Xinjiang Uygur Autonomous Region
2022-2023
Nanjing Medical University
2021-2022
Sinopec (China)
2019-2020
HDAC6, a structurally and functionally unique member of the histone deacetylase (HDAC) family, is an important host factor that restricts viral infection. The broad-spectrum antiviral activity HDAC6 makes it potent agent. Previously, we found functions to antagonize porcine deltacoronavirus (PDCoV), emerging enteropathogenic coronavirus with zoonotic potential. However, final outcome typically productive infection materializes as cells succumb infection, indicating virus has evolved...
Abstract Background Although China has eliminated absolute poverty, the effects of sickness still pose a threat to prospect returning poverty in western rural areas. However, governance extends beyond solving and should enhance family’s ability resist risks, proactively identify existence facilitate preventive measures reduce probability falling into again. This study aimed assess health vulnerability households decompose its determinants. Methods Based on survey data from 2022, three-stage...
SUMMARY LHC assembly is a fundamental process in forming peripheral antenna system, which has significant impact on photosynthesis. However, the molecular mechanism of still needs to be further investigated monocotyledonous plants. Here, we identified bifunctional protein YGL9 rice, homolog cpSRP43 Arabidopsis , mediates by simultaneously regulating LHCPs transport and chlorophyll synthesis. Mutation exhibits yellow‐green leaf phenotype, with reduced contents, impaired photosystem activity...
Porcine deltacoronavirus (PDCoV), an emerging enteropathogenic coronavirus, not only causes diarrhea in piglets but also possesses the potential to infect humans. To better understand host-virus genetic dependencies and find therapeutic targets for PDCoV, we used a porcine single-guide RNA (sgRNA) lentivirus library screen host factors related PDCoV infection LLC-PK1 cells. The solute carrier family 35 member A1 (SLC35A1), key molecule sialic acid (SA) synthesis pathway, was identified as...
The patterning of adaxial-abaxial tissues plays a vital role in the morphology lateral organs, which is maintained by antagonism between genes that specify adaxial and abaxial tissue identity. homeo-domain leucine zipper class III (HD-ZIP III) family regulate identity; however, little information known about physical interactions or transcriptionally regulated downstream HD-ZIP III. In this study, we identified dominant rice mutant, floret 1 (lf1), has defects organ polarity. LF1 encodes...
Abstract Background Infertility has troubled millions of people worldwide while always being an ignored issue. The high cost treatment or lack services placed a barrier to the alleviation infertility status. Governments play significant role promote infertility-related policies for better access and comprehensive supports infertile people. Methods Data status indicators in ten representative countries were collected. An policy system was established, then classification quantification...
Abstract Leaf morphology is one of the most important features ideal plant architecture. However, genetic and molecular mechanisms controlling this feature in crops remain largely unknown. Here, we characterized rice (Oryza sativa) wide leaf 1 (wl1) mutant, which has wider leaves than wild-type due to more vascular bundles greater distance between small bundles. WL1 encodes a Cys-2/His-2-type zinc finger protein that interacts with Tillering Dwarf (TAD1), co-activator anaphase-promoting...
Leaves and glumes act as lateral organs have essential effects on photosynthesis seed morphology, thus affecting yield. However, the molecular mechanisms controlling their polarity development in rice is still worth further analysis. Here, we isolated a defect of 1 (pdl1) mutant rice, which exhibits twisted/filamentous-shaped leaves cracked/filamentous-shaped lemmas caused by defects development. PDL1 encodes SUPPRESSOR OF GENE SILENCING 3 protein localized cytoplasm granules. expressed...
Abstract Bacteria employ various strategies to coordinate population-level behaviors, with quorum sensing being a well-established mechanism. Here, we report novel regulatory mechanism in Pseudomonas aeruginosa , which term ‘pressorum sensing’. This allows bacteria modulate their collective behavior response growth-induced mechanical compression confined spaces. Using highly sensitive cAMP biosensor combination microfluidics, demonstrate that when compressive forces reach approximately 30...
ABSTRACTPorcine deltacoronavirus (PDCoV) is an emerging enteric coronavirus that has been reported to infect a variety of animals and even humans. Cell-cell fusion identified as alternative pathway for the cell-to-cell transmission certain viruses, but ability PDCoV exploit this model, relevant mechanisms, have not fully elucidated. Herein, we provide evidence main mechanism supporting spread in cell culture efficient model mediated by spike glycoprotein-driven cell-cell fusion. We found...
Multiple chronic conditions (MCC) refer to the presence of two or more diseases. The incidence MCC is higher in older people, and increases with age. Studies have shown an association between increased adverse outcome, as well mortality, decline physical function, poor quality life populations. Herein, for first time we provide data ethnic geographic variations prevalence among community-dwelling people Xinjiang, China.A multilevel random sampling method was employed perform epidemiological...
Abstract In the past decade, government of China has implemented healthcare reforms to provide universal access by 2020. We aimed systematically analyse dynamic changes in health services and equity during 10 years understand correlation between social-economic status. performed a longitudinal study which we extracted aggregated data mainly from project (2009, 2011, 2012, 2015, 2019). A multi-stage stratified cluster randomized design was used obtain representative sample each county....
Glufosinate-ammonium (GLA) is a widely used herbicide with emerging concern over its male reproductive toxicity. Abnormalities in sperm histone modification induced by GLA exposure observed our previous study aroused interest whether such alterations could further affect embryonic gene expression. Here we administered adult mice 0.2 mg/kg⋅day of for 5 weeks to collect their or 4-cell embryos after copulation. Cleavage Under Targets and Tagmentation (CUT&Tag) sequencing showed H3...
Inflammatory reactions play a significant role in the occurrence and development of sarcopenia. Determining association between specific cytokines sarcopenia may reveal disease's pathophysiological mechanism(s). Accordingly, present study aimed to investigate inflammatory among elderly natural population agricultural pastoral areas Xinjiang.We conducted cross-sectional epidemiological survey community-dwelling older people using multi-stage random sampling method Mulei County northern...
Retrograde transport has been reported to be closely associated with normal cellular biological processes and viral replication. As an emerging enteropathogenic coronavirus zoonotic potential, porcine deltacoronavirus (PDCoV) attracted considerable attention. However, whether retrograde is PDCoV infection remains unclear. Our present study demonstrates that retromer protein VPS35 acts as a critical host factor required for infection. Mechanically, interacts NS6, mediating the of NS6 from...