A5008862379- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Natural product bioactivities and synthesis
- Catalytic C–H Functionalization Methods
- Photorefractive and Nonlinear Optics
- Chemical synthesis and alkaloids
- Bioactive Compounds and Antitumor Agents
- Radical Photochemical Reactions
- Phytochemical compounds biological activities
- Alkaloids: synthesis and pharmacology
- Photonic and Optical Devices
- Traditional and Medicinal Uses of Annonaceae
- Advanced Fiber Laser Technologies
- Lymphoma Diagnosis and Treatment
- Oxidative Organic Chemistry Reactions
- Sulfur-Based Synthesis Techniques
- Solid State Laser Technologies
- Synthesis of Indole Derivatives
- Phytoestrogen effects and research
- Marine Sponges and Natural Products
- Synthesis and Biological Activity
- Heat shock proteins research
- Chemical Synthesis and Reactions
- Crystallography and molecular interactions
- Sesquiterpenes and Asteraceae Studies
Yunnan University of Traditional Chinese Medicine
2020-2024
Xuzhou Medical College
2021-2023
First Affiliated Hospital of Anhui Medical University
2022
Anhui Medical University
2022
Beijing Foreign Studies University
2022
Xiangtan University
2021
Chinese Academy of Sciences
2007-2020
Kunming Institute of Botany
2011-2020
Yangtze University
2019
Kunming University
2018
Anti-CD30 CAR-T is a potent candidate therapy for relapsed/refractory (r/r) CD30+ lymphomas with limitations, and the efficacy needed to be further improved. Herein multi-center phase II clinical trial (NCT03196830) of anti-CD30 treatment combined PD-1 inhibitor in r/r lymphoma was conducted. After lymphocyte-depleting chemotherapy fludarabine cyclophosphamide, 4 patients cohort 1 3 2 received 106/kg 107/kg cells, respectively, 5 cells anti-PD-1 antibody. The safety cell were analyzed....
A facile and straightforward method was developed to construct the fused tetracyclic 3-spirooxindole skeleton, which exists widely in natural products. The formation of structure achieved through a transition-metal-free intramolecular cross-dehydrogenative coupling pyridinium, were formed situ by condensation 3-(2-bromoethyl)indolin-2-one derivatives with 3-substituted pyridines. As examples application this new methodology, two potentially medicinal products, (±)-corynoxine B, efficiently...
A short scalable biomimetic route to bioactive natural product bimagnolignan (1) was accomplished. Compound 1 successfully prepared through a three-step metal-free synthesis from honokiol (2). Alternatively, also synthesized by transformations that mimic tyrosinase in four steps. The key reactions feature regioselective acetylation, highly efficient C(sp2)–H oxidation, cascade aerobic oxidative cyclization/coupling, and Cu-catalyzed direct coupling. In addition, cell-based assays validate is...
An unprecedented copper-catalyzed intramolecular radical cyclization was developed for the synthesis of 3-hydroxypyrroloindoline skeletons in excellent yields. The 3-hydroxyl group introduced by trapping intermediate with molecular oxygen or TEMPO. This process represents a unique oxidation pathway tryptamine/tryptophan derivatives and allows rapid biomimetic natural product protubonine A.
A Curtius-like rearrangement of hydroxamates to isocyanates was discovered. This reaction initiated from an iron(II)–nitrenoid complex, which generated by the iron(II)-catalyzed cleavage N–O bonds functionalized hydroxamates. To demonstrate efficiency this new in synthetic chemistry, a biomimetic strategy for one-pot preparation bisindolylmethanes developed.
A copper-mediated cyclization and dimerization of tryptamine or tryptophan was developed to generate a C2-symmetry C3(sp3)–C3(sp3) bridge with two contiguous stereogenic quaternary carbons in one step. Impressively, the ratio between exo endo products varies when different protecting groups Nb are utilized. This reaction could be conducted gram scale. With this method, both endocyclotryptophan (+)-WIN 64821 exocyclotryptophan (−)-ditryptophenaline were synthesized 5 steps.
An efficient copper-catalyzed radical decarboxylative imidation reaction is presented.
Background CD5‐positive diffuse large B‐cell lymphoma (DLBCL) is a clinically rare subtype of DLBCL with aggressive clinical manifestations and poor prognosis. It has been demonstrated that the prognostic nutritional index (PNI), an indicator status systemic inflammation, significant factor for several types lymphoma. The objective this multicenter retrospective study was to explore value PNI in patients DLBCL. Methods In total, 207 were recruited from 11 centers Huaihai Lymphoma Working...
Immunonutritional status is associated with the survival of DLBCL. This multicenter retrospective study aimed to explore prognostic value Prognostic Nutrition Index (PNI) in DLBCL patients by using propensity score matched analysis (PSM).A total 990 cases were recruited from 5 centers Huaihai Lymphoma Working Group (HHLWG). A 1:1 PSM was performed nearest-neighbor method, a caliper size 0.02. Cox regression used examine factors survival.The median age at diagnosis 62 years and 52.5% males,...
24 C3'-focused hybrids of aryl/penta-1,4-dien-3-one/amine (APDA) were designed and synthesized. Of these hybrids, 2 n demonstrated improved antiproliferative effects on HER2-positive breast cancer cells (SKBr3 BT474) triple-negative (TNBC) (MDA-MB-231 MDA-MB-468) with IC
The direct 2-alkylation of oxazoles and thiazoles with ethers through cross-dehydrogenative coupling reaction using Co-containing mesoporous zeolite ETS-10 as the heterogeneous catalyst is described. basic facilitates this metal-base synergy catalytic principle.
Seven unprecedented high molecular weight hybrids of cycloartane triterpenoid saponins and chromone glycosides, namely, Cimitriteromone A–G (1–7), three known biogenetic precursors (8–10) were isolated from the rhizomes Cimicifuga foetida by using HPLC-UV/MS method. The structures new compounds determined NMR analysis HRESIMS data. absolute configurations sugar moieties established a chemical 2 4 showed antiproliferative activities against Taxol-resistant human lung cancer A-549/Taxol with...
Direct γ-C(sp 3 )-arylation of unactivated electron-rich enones remains a challenge. We have found Pd-catalyzed method for direct β-alkoxy cyclohexenones which enables the synthesis bioactive CBD-like compounds.
A Pd-catalyzed one-pot sequential C–H functionalization strategy was utilized to prepare four lycorine alkaloids and one pseudo-lycorine alkaloid from the common intermediate 4. By switching followed oxidative conditions of air, DMSO/H2O/I2, DMSO/O2, based on Pd(PPh3)4/K2CO3/toluene catalytic system, three key intermediates 12a, 12b, 12c with different substitution patterns could be obtained in a well-controlled manner. As result, natural products γ-lycorane, hippadine, anhydrolycorinone,...
To enrich the bioactive cycloartane triterpenoid glycoside named actein and find out more cytotoxic triterpenes, a phytochemical study of Cimicifuga foetida was conducted. 113 g (0.17%) purified by recrystallization while eight cycloartane-type triterpenes (1-8) were isolated from mother liquid. The chemical structures new compounds (1-4) elucidated 1D 2D NMR HRESIMS spectroscopic analyses. Moreover, showed moderate broad-spectrum cytotoxicity against 5 human cancer cell lines with IC
Compound 1z, a thermostable silicon-containing aryl/penta-1,4-dien-3-one/amine hybrid kills breast cancer cells by targeting the HSP90 C-terminus without inducing heat-shock response.
Based on a modified coupled wave theory, the pulse shaping properties of volume holographic gratings (VHGs) in anisotropic media VHGs are studied systematically. Taking photorefractive LiNbO(3) crystals as an example, combined effect that grating parameters, dispersion and optical anisotropy crystal, width, polarization state input ultrashort pulsed beam (UPB) have considered when UPB with arbitrary propagates through VHG. Under effect, diffraction bandwidth, profiles diffracted transmitted...