A5078094322- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Phytochemistry and Biological Activities
- Natural product bioactivities and synthesis
- Pharmacological Effects of Natural Compounds
- Plant-based Medicinal Research
- Phytochemistry and Bioactive Compounds
- Magnolia and Illicium research
- Traditional and Medicinal Uses of Annonaceae
- Bioactive natural compounds
- Asthma and respiratory diseases
- Biological Activity of Diterpenoids and Biflavonoids
- Bioactive Compounds and Antitumor Agents
- Phytochemistry and Bioactivity Studies
- Medicinal plant effects and applications
- Manufacturing Process and Optimization
- Product Development and Customization
- Biological and pharmacological studies of plants
- Morinda citrifolia extract uses
- Pediatric health and respiratory diseases
- Microbial Natural Products and Biosynthesis
- Clinical Laboratory Practices and Quality Control
- Gout, Hyperuricemia, Uric Acid
- Material Dynamics and Properties
- Quantum many-body systems
Yunnan University
2009-2025
Yunnan University of Traditional Chinese Medicine
2013-2025
Yunnan Provincial Department of Education
2022-2025
Institute of Physics
2022
Chinese Academy of Sciences
2022
University of Chinese Academy of Sciences
2022
Shandong University
1993-2015
The size effect on the ferroelectric phase transition in PbTiO3 ultra-fine particles is reported. Samples with particle sizes from 20 to 200 nm were prepared by a sol-gel process followed calcining at different temperatures. was determined X-ray diffraction integrated width of diffractions. soft-mode frequency room temperature measured Raman scattering. It decreases decreasing size. traced specific-heat measurement. and becomes diffused as decreases. dependence TC can be described...
Operator spreading, often characterized by out-of-time-order correlators (OTOCs), is one of the central concepts in quantum many-body physics. However, measuring OTOCs experimentally challenging due to requirement reversing time evolution systems. Here we apply Floquet engineering investigate operator spreading a superconducting 10-qubit chain. provides an effective way tune coupling strength between nearby qubits, which used demonstrate walks with tunable couplings, reversed evolution, and...
A short scalable biomimetic route to bioactive natural product bimagnolignan (1) was accomplished. Compound 1 successfully prepared through a three-step metal-free synthesis from honokiol (2). Alternatively, also synthesized by transformations that mimic tyrosinase in four steps. The key reactions feature regioselective acetylation, highly efficient C(sp2)–H oxidation, cascade aerobic oxidative cyclization/coupling, and Cu-catalyzed direct coupling. In addition, cell-based assays validate is...
Through investigated the consequences of involucrasins for possible prevention COVID-19 by molecular docking using Autodock Vina and dynamics (MD) simulations Gromacs2020 software. Docking results showed that ligands bound tightly to Delta variant, Omicron angiotensin-converting enzyme 2 (ACE2) protein, while dynamic revealed ability bind ACE2. In addition, were able inhibit binding between RBD (Delta variant or Omicrion variant) SARS-CoV-2 S protein ACE2 through bilayer interferometry (BLI)...
Renifolin F is a prenylated chalcone isolated from Shuteria involucrata, traditional minority ethnic medicine used to treat the respiratory diseases and asthma. Based on effects of original plant, we established an in vivo mouse model allergic asthma using ovalbumin (OVA) as inducer evaluate therapeutic F. In research, mice were sensitized challenged with OVA establish The airway hyper-reactivity (AHR) methacholine, cytokine levels, ILC2s quantity mircoRNA-155 expression assessed. We...
Two new chalcones, 2',3,4,4'-tetrahydroxy-2-prenylchalcone (1) and 3-methoxy-2',4,4'-trihydroxy-2-prenylchalcone (2), together with two known compounds, munsericin (3) 3,4-dihydroxylonchocarpin (4), were isolated from the ethanol extract of whole plant Shuteria sinensis. Their structures identified by spectroscopic analysis methods, such as 1D 2D NMR, along HR-MS data. Glucose metabolism activity four compounds was tested, 3 4 showed effect on glucose consumption insulin-resistant HepG2 cells.
(±)-Involucrasins A (1) and B (2), two pairs of flavanone enantiomers were isolated from Shuteria involucrata. Structurally, both 1 2 are rare representatives 5-dehydroxy/5-demethoxy 2',3',4'-trisubstituted flavanones. Their structures elucidated on the basis comprehensive spectroscopic data analysis comparison with literature data. Involucrasin (2) exhibited moderate anti-proliferative activity against Caco-2, MCF-7, MDA-MB-468, HCT116 cell lines IC50 values ranging 7.9-22.7 μM. weak...
Skeleton-diversity-oriented chemical conversion from pure natural products is a valuable method to obtain product-like compounds, especially those with novel architecture. The application of phytochemical methods iridoids yielded three secoiridoid dimers: sweritranslactones A–C (1–3). These molecules possess 6/6/6/6/6/6-fused hexacyclic skeleton and were obtained swertiamarin, one the major constituents genus Swertia, via [4 + 2] cycloaddition intramolecular nucleophilic addition under...
Colorectal cancer (CRC) is the second leading cause of mortality worldwide; however, there still a lack effective clinical anti-CRC agents. Naturally-occurring compounds have been considered potentially valuable source new antitumorigenic Involucrasin A, novel natural molecule, was isolated from Shuteria involucrata (Wall.) Wight & Arn by our team. In present study, anticancer activity involucrasin A in HCT-116 CRC cells evaluated. Firstly, anti-proliferative effect on analyzed...
ObjectiveSwertiamarin (STM) belongs to iridoid class of compounds, and the heat-transformed products (HTPS) are produced by STM in process drug processing. The purpose this study was explore protective effect mechanism or HTPS on acetaminophen (APAP)-induced hepatotoxicity.MethodsMice L-O2 cells were given APAP establish hepatotoxicity model vivo vitro. effects oxidative stress, inflammation, apoptosis induced evaluated, with N-acetylcysteine (NAC) as a positive control.ResultsSTM reduced...
The bark of Streblus indicus, a Dai medicine in China, has been listed the Chinese Materia Medica as possessing hemostatic and analgesic properties. Ethnic books record that its or leaves for treatment mumps lymphoma. However, according to literature survey, anti-inflammatory studies available branches S. indicus have seldom reported so far. current study focuses on metabolites responsible effects basis bioactive-included acetic acid writhing, hot-plate, xylene-induced ear swelling....
(±)-Involucrasin C (1), a pair of new 2,3-dihydro-1H-indene enantiomers, along with an enantiomeric analog (2), were isolated from Shuteria involucrata. Their structures established by the basis comprehensive spectroscopic data analysis and X-ray crystallographic diffraction. Both 1 2 significantly inhibited secretion pro-inflammatory cytokines IL-6, TNF-α, IL-1β, suggesting that these two natural derivatives may be active components S. involucrata block inflammation in initial stage.
(1) Background: Colorectal cancer (CRC) is the third most common malignant tumor worldwide and second cause of death. However, effective anti-CRC drugs are still lacking in clinical settings. This article investigated anti-proliferative effect involucrasin B on CRC Caco-2 cells. (2) Methods: study employed a sulforhodamine (SRB) method, colony formation experiments, flow cytometry, FastFUCCI assay, dual luciferase Western blot analysis for investigation. (3) Results: The SRB method...
An undescribed bisflavonoid, named involucrasin D (
Background As one of the most common gynecological disorders, PD significantly impacts quality life for women. TSD, a well-known traditional Chinese medical prescription, has gained popularity its use in treating cold coagulation and blood stasis syndromes such as PD. However, lack comprehensive data hinders our understanding molecular mechanism. Purpose The objective present study is to investigate therapeutic effects TSD on elucidate plausible Methods HPLC was employed confirm presence...
, a distinctive Yi medicine, utilized the roots as an essential medicinal substance for trauma treatment of "Yunnan Hong Yao".