A5101801292- Natural product bioactivities and synthesis
- Fungal Biology and Applications
- Bioactive Compounds and Antitumor Agents
- Phytochemistry and Biological Activities
- Phytochemistry and Bioactivity Studies
- Phytochemical compounds biological activities
- Advances in Cucurbitaceae Research
- Cholinesterase and Neurodegenerative Diseases
- Sesquiterpenes and Asteraceae Studies
- Carbohydrate Chemistry and Synthesis
- Plant biochemistry and biosynthesis
- Natural Antidiabetic Agents Studies
- Traditional and Medicinal Uses of Annonaceae
- Plant chemical constituents analysis
- Phytochemistry and Bioactive Compounds
- Plant Toxicity and Pharmacological Properties
- Essential Oils and Antimicrobial Activity
- Synthesis and Biological Activity
- Chemical synthesis and alkaloids
- Bioactive Natural Diterpenoids Research
- Coffee research and impacts
- Phytoestrogen effects and research
- Biological Activity of Diterpenoids and Biflavonoids
- Medicinal plant effects and applications
- Toxin Mechanisms and Immunotoxins
Tianjin Normal University
2025
Chinese Academy of Sciences
2015-2025
Shanghai Institute of Microsystem and Information Technology
2023-2025
Anhui Polytechnic University
2025
State Key Laboratory of Transducer Technology
2023-2025
Kunming Institute of Botany
2014-2023
University of Chinese Academy of Sciences
2015-2022
Kunming University
2015-2021
State Council of the People's Republic of China
2015-2021
Academia Sinica
2021
Two novel trinorlanostanes, cochlates A and B (1 2), with a 3,4-seco-9,10-seco-9,19-cyclo skeleton, as well six new triterpenoids, fornicatins D–F (3–5) ganodercochlearins A–C (6–8), together five known triterpenoids (9–13), were obtained from the fruiting bodies of Ganoderma cochlear. The structural elucidation was achieved by interpretation spectroscopic data, compounds 2 7a further characterized X-ray crystallographic analysis. Fornicatins A, D, F (10, 3, 5) fredelin (13) lowered ALT AST...
N-Iodosuccinimide-promoted cascade reactions of arylidene isoxazolones with amidines in p-xylene were accomplished, affording 5-acylimidazoles good to excellent yields. Interestingly, when the performed by employing acetonitrile as solvent, 4-acylimidazoles efficiently obtained. Mechanistic studies indicate that formation imidazolyl and acyl moieties may undergo a spiroannulation-ring opening aromatization-hydrolysis reaction sequence. Based on this solvent-regulated tandem strategy,...
We have developed, for the first time, a visible light-induced radical cascade difluoromethylation/cyclization reaction of 1-acryloyl-2-cyanoindoles with [bis(difluoroacetoxy)iodo]benzene under catalyst-free conditions. The use shelf-stable and easily accessible difluoromethylation reagents, combined environmentally friendly mild conditions, makes this method an alternative strategy synthesis difluoroalkylated pyrrolo[1,2-a]indolediones.
By integrating 3D-inkjet bioprinting technology, differentiated human cells can be assembled into artificial lung tissue structure to achieve a rapid, efficient, and reproducible disease model construction process. Here, we developed novel bioprinting-based method construct (ALTs) for acute injury (ALI) modeling, research application. It also used study the role of relevant in by adjusting cell type adapted bio-functions immune during cell-cell interactions. Firstly, series process...
(±)-Ganoapplanin (1), a pair of novel meroterpenoid enantiomers featuring an unprecedented dioxaspirocyclic skeleton constructed from 6/6/6/6 tetracyclic system and unusual tricyclo[4.3.3.03′,7′]dodecane motif, were isolated Ganoderma applanatum. Its structure absolute configurations determined by spectroscopic analyses, X-ray crystallography, ECD (electronic circular dichroism calculations). A plausible biogenetic pathway, involving key Gomberg–Bachmann reaction, was also proposed for...
Twelve new diterpenoids based on two rare skeletal types, namely, paralianones A–D (1–4) and pepluanols A–H (5–12), along with five known compounds, were isolated from an acetone extract of Euphorbia peplus. Their structures proposed 1D 2D NMR spectroscopic data analysis. These evaluated for potential anti-inflammatory activity in a lipopolysaccharide-stimulated mouse macrophage cellular model. Compounds 3, 4, 11, 13, 16 displayed moderate inhibitory effects NO inhibition, IC50 values...
(±)-spiroganoapplanin A ( 1 ) with a polycyclic meroterpenoid from Ganoderma applanatum showed potential anti-AD’s effect by reducing Aβ42 production and inhibiting Tau phosphorylation through BACE1, CDK5, GSK3β-mediated pathways.
Five new diterpenoid glucosides, named mascaroside I (1), II (2), paniculoside VI (3), cofaryloside (4), and villanovane (5), along with seven known ent-kaurane glucosides (6–12) were isolated from acetone extracts of the roasted coffee beans Coffea arabica var. yunnanensis. Their structures established by extensive spectroscopic analysis including 1D 2D NMR (HSQC, HMBC, COSY, ROESY) comparison published data. Cytotoxicities evaluation isolates showed that they inactive against HL-60,...
Five new ent-kaurane diterpenoids, named mascaroside III–V (1–3), and 20-nor-cofaryloside I–II (4–5), together with seven known were isolated from methanol extracts of the green coffee beans Yunnan Arabica Coffee. Their chemical structures elucidated by extensive spectroscopic analyses. Meanwhile, cytotoxicity assay against HL-60, A-549, SMMC-7721, MCF-7 SW480 cell lines showed that they have not evident inhibition cytotoxicity.
Eight new limonoids, toononoids A–H (1–8), eight B-seco-29-norlimonoids, toonanoronoids (9–16), and seven known analogues were obtained from the EtOAc extract of twigs leaves Toona ciliata. Compounds 2, 4, 8, 16 are rare lactam-bearing limonoids. 1, 14, 15 possess an unusual γ-methoxybutenolide moiety at C-17, while compounds 9, 10, have a 3β-hydroxy group. Their 2D structure relative configurations identified using spectroscopic data. The absolute established via X-ray diffraction...
Our previous research has shown that lanostane triterpenoids from Ganoderma applanatum exhibit significant anti-adipogenesis effects. In order to obtain more structurally diverse establish a structure–activity relationship, we continued the study of fruiting bodies G. applanatum, and forty highly oxygenated lanostane-type triterpenoinds (1–40), including sixteen new compounds (1–16), were isolated. Their structures elucidated using NMR spectra, X-ray crystallographic analysis, Mosher’s...
Five new cucurbitacins, kuguacins II–VI (<b>1</b>–<b>5</b>), along with five known analogues (<b>6</b>–<b>10</b>), were obtained from the fruit of <i>Momordica charantia</i>. Structures compounds elucidated as 5<i>β</i>,19-epoxycucurbit-23-en-7-on-3<i>β,</i>25-diol (<b>1</b>), 5<i>β</i>,19-epoxycucurbit-7,23-dion-3<i>β,</i>25-diol (<b>2</b>), 5<i>β</i>,19-epoxycucurbit-6-en-19,23-dion-3<i>β,</i>25-diol (<b>3</b>),...
Ganocochlearic acid A (<bold>1</bold>) was a rearranged hexanorlanostane triterpenoid featuring γ-lactone ring and five-membered carbon ring. Compound <bold>4</bold> exhibited relatively potent cytotoxic activity against MCF-7 cells (IC<sub>50</sub>: 9.15 μM).