A5068990085- CAR-T cell therapy research
- Virus-based gene therapy research
- Lymphoma Diagnosis and Treatment
- Viral Infectious Diseases and Gene Expression in Insects
- Advancements in Semiconductor Devices and Circuit Design
- Stroke Rehabilitation and Recovery
- Viral-associated cancers and disorders
- Venous Thromboembolism Diagnosis and Management
- Chronic Myeloid Leukemia Treatments
- Blood Coagulation and Thrombosis Mechanisms
- Immune Cell Function and Interaction
- Multiple Myeloma Research and Treatments
- Nanowire Synthesis and Applications
- Functional Brain Connectivity Studies
- Cancer Cells and Metastasis
- EEG and Brain-Computer Interfaces
- Integrated Circuits and Semiconductor Failure Analysis
- Hematopoietic Stem Cell Transplantation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Liver physiology and pathology
- Histone Deacetylase Inhibitors Research
- Erythrocyte Function and Pathophysiology
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Kruppel-like factors research
- Animal Disease Management and Epidemiology
Xuzhou Medical College
2014-2024
Southern Medical University
2023-2024
Nanfang Hospital
2023-2024
Cell Technology (China)
2023
Yunnan Agricultural University
2020-2021
Kōchi University
2017-2018
Fukushima Medical University
2017-2018
Nanjing Medical University
2018
Jiangsu Province Hospital
2018
East China Normal University
2016
Macrophage infiltration is a hallmark feature of viral myocarditis. As studies have shown that microRNA-155 regulates the differentiation macrophages, we aimed to investigate role in VM. We report silencing protects mice from coxsackievirus B3 induced found expression was upregulated and localized primarily heart-infiltrating macrophages CD4(+) T lymphocytes during acute In contrast with wildtype (WT) mice, microRNA-155(-/-) developed attenuated myocarditis, which characterized by decreased...
Abstract Systematic and dynamic humoral immune reconstitution is little-known for patients with relapsed/refractory (R/R) multiple myeloma (MM) who received anti–B-cell maturation antigen (BCMA) chimeric receptor (CAR) T-cell therapy. We investigated the kinetics of B-cell, normal plasma cell, immunoglobulin recovery in 40 achieved ongoing response after anti-BCMA CAR All developed B-cell aplasia median duration was 70 days (range, 23-270). The count reached its nadir on day 7 returned to...
Clinical trials have confirmed that chimeric antigen receptor (CAR) T cell therapies are revolutionizing approaches for treating several relapsed or refractory hematological tumors. Cytokine release syndrome (CRS) is an adverse event with high incidence during CAR-T treatment. A further understanding of the characteristics and related risk factors CRS important effective management. total 142 patients acute lymphocyte leukemia (ALL), lymphoma, multiple myeloma (MM) received lymphodepletion...
Anti-CD30 CAR-T is a potent candidate therapy for relapsed/refractory (r/r) CD30+ lymphomas with limitations, and the efficacy needed to be further improved. Herein multi-center phase II clinical trial (NCT03196830) of anti-CD30 treatment combined PD-1 inhibitor in r/r lymphoma was conducted. After lymphocyte-depleting chemotherapy fludarabine cyclophosphamide, 4 patients cohort 1 3 2 received 106/kg 107/kg cells, respectively, 5 cells anti-PD-1 antibody. The safety cell were analyzed....
Chimeric antigen receptor (CAR)-T cell therapy, a new immunotherapy for relapsed and refractory (R/R) hematologic malignancies, can be accompanied by adverse events, including coagulation disorders. Here, we performed comprehensive analysis of parameters in 100 patients with R/R malignancies after receiving CAR-T therapy to illuminate the profiles disorders facilitate management A high incidence was observed, elevated D-dimer (50/100, 50%), increased fibrinogen degradation product (45/100,...
The primary motor cortex (M1) is often abnormally recruited in stroke patients with disabilities. However, little known about the alterations causal connectivity of M1 following stroke. purpose present study was to investigate whether effective ipsilesional disturbed who show different outcomes hand function. 23 left-hemisphere subcortical were selected and divided into two subgroups: partially paralyzed hands (PPH) completely (CPH). Further, 24 matched healthy controls (HCs) recruited. A...
Summary Thrombomodulin (TM) exerts cytoprotection via the fifth region of epidermal growth factor (EGF)-like domain TM (TME5) by interacting with G-protein coupled receptor 15 (GPR15) expressed on cell surface vascular endothelial cells. is also implied to mediate anti-inflammatory functions unknown mechanism. By applying a lipopolysaccharide (LPS)-induced murine sepsis model, we assessed role TME5 in septic inflammation and coagulation. We found that treatment protected mice association...
Thrombomodulin (TM) exerts anti-inflammatory functions. We previously found that recombinant human soluble TM alleviated murine graft-versus-host disease (GVHD). Nevertheless, it is unclear how mediates its functions in GVHD. Here, we identified G-protein coupled receptor 15 (GPR15) expressed on T cells as a receptor/sensor of TM. The fifth region epidermal growth factor–like domain (TME5) bound GPR15 vitro. TME5 prolonged survival mice undergoing acute GVHD after allogeneic hematopoietic...
Thrombomodulin (TM) stimulates angiogenesis and protects vascular endothelial cells (ECs) via its fifth epidermal growth factor-like region (TME5); however, the cell surface receptor that mediates pro-survival signaling activated by TM has remained unknown. We applied pull-down assay followed MALDI-TOF MS western blot analysis, identified G-protein coupled 15 (GPR15) as a binding partner of TME5. TME5 rescued inhibition apoptosis caused calcineurin inhibitor FK506 in ECs isolated from wild...
Abstract Introduction Anti‐CD19 chimeric antigen receptor (CAR) ‐T cells, which recognize and kill both B lymphoblasts normal result in cell aplasia humoral immunodeficiency. However, there were only a few detailed reports on the profile of immune reconstitution after anti‐CD19 CAR‐T therapy. Methods Thirty nine patients with relapsed or refractory (R/R) acute lymphoblastic leukemia (ALL) receiving therapy enrolled. Subjects died, relapsed, received other treatment, lost to follow‐up within...
Early response could be obtained in most patients with relapsed or refractory B cell lymphoblastic leukemia (R/R B-ALL) treated chimeric antigen receptor T-cell (CAR-T) therapy, but relapse occurs some patients. There is no consensus on treatment strategy post CAR-T therapy. In this retrospective study of humanized CD19-targeted (hCART19s) therapy for R/R B-ALL, we analyzed the allogeneic hematopoietic stem transplantation (allo-HSCT) received a second hCART19s infusion, and summarized their...
Small monomeric G proteins regulated in part by GTPase-activating (GAPs) are molecular switches for several aspects of vesicular transport. The yeast Gcs1 protein is a dual-specificity GAP ADP-ribosylation factor (Arf) and Arf-like (Arl)1 proteins, also has GAP-independent activities. absence imposes cold sensitivity growth endosomal transport; here we present evidence that dysregulated Arl1 may cause these impairments. We show gene deletions affecting the or Ypt6 vesicle-tethering pathways...
Previous studies have shown that the satisfaction of basic psychological needs is related to well-being. Improving will increase personal well-being, promote positive health outcomes, and improve disease recovery. However, no research has focused on stroke patients. Therefore, this study aims determine experience, satisfaction, its influencing factors patients.12 males 6 females in non-acute phase with were recruited Department Neurology, Nanfang Hospital. The individual, semi-structured...
Abstract Background Tocilizumab is commonly used for the management of chimeric antigen receptor (CAR) T‐cell therapy–associated cytokine release syndrome (CRS). However, it remains unknown whether tocilizumab or its dosage affects efficacy and safety CAR therapy. The objective this multicenter retrospective study was to explore impact on Methods In total, 93 patients with B‐cell acute lymphoblastic leukemia (B‐ALL) receiving humanized anti‐CD19 T cells were recruited from May 2016 November...
Sinusoidal obstruction syndrome is a life-threatening complication that can occur after haematopoietic stem cell transplantation. Defibrotide (DF) has been approved for the treatment of individuals with severe sinusoidal following transplantation in European Union and United States. However, precise mechanisms by which DF protects endothelial cells remain to be elucidated. In this study, we found stimulated angiogenesis vitro vivo as assessed vascular tube formation, scratch-wound repair...
We previously found that the fifth epidermal growth factor-like domain of thrombomodulin (TME5) exerts cytoprotective and pro-angiogenic functions via G-protein coupled receptor 15 (GPR15). TME5 is comprised three S-S bonds divide it into loops: A (TME5A), B (TME5B), C (TME5C). Herein we identified minimum structure produces favorable effects in vascular endothelial cells (ECs). TME5C, composed 19 amino acids, but not TME5A or TME5B, stimulated proliferation human umbilical vein (HUVECs)...
Epstein-Barr virus (EBV) is a type of human <i>γ</i>-herpesvirus, and its reactivation plays an important role in the development EBV-driven Burkitt lymphoma (BL). Despite intensive chemotherapy, prognosis relapsed/refractory BL patients remains unfavorable, definitive method to completely eliminate latent EBV infection lacking. Previous studies have demonstrated that histone deacetylase (HDAC) inhibitors can induce transition from latency lytic phase. The activation be inhibited by...
Microcystins are waterborne environmental toxins that induce oxidative stress and cause injuries in the heart. On other hand, many physiological processes, including antioxidant defense, under precise control by mammalian circadian clock. In present study, we evaluated effect of microcystin-LR (MC-LR) on rhythmic expression patterns genes rat cardiomyocytes using serum shock technique. We found a non-toxic dose (10 μm) MC-LR decreased amplitudes clock genes, while it increased levels genes....