A5100322861- Sirtuins and Resveratrol in Medicine
- Caveolin-1 and cellular processes
- Genomics, phytochemicals, and oxidative stress
- High Altitude and Hypoxia
- Pharmacogenetics and Drug Metabolism
- Thyroid Disorders and Treatments
- Cancer, Stress, Anesthesia, and Immune Response
- Cell death mechanisms and regulation
- Redox biology and oxidative stress
- PARP inhibition in cancer therapy
- Xenotransplantation and immune response
- Renal Transplantation Outcomes and Treatments
- Autophagy in Disease and Therapy
- MicroRNA in disease regulation
- Heme Oxygenase-1 and Carbon Monoxide
- Cancer therapeutics and mechanisms
- Intestinal and Peritoneal Adhesions
- RNA regulation and disease
- Glioma Diagnosis and Treatment
- Virus-based gene therapy research
- Growth Hormone and Insulin-like Growth Factors
- Neuroblastoma Research and Treatments
- Tissue Engineering and Regenerative Medicine
- Abdominal Surgery and Complications
- CAR-T cell therapy research
Xuzhou Medical College
2016-2024
Second People’s Hospital of Huai’an
2024
First Affiliated Hospital of Xiamen University
2018
Clinical trials have confirmed that chimeric antigen receptor (CAR) T cell therapies are revolutionizing approaches for treating several relapsed or refractory hematological tumors. Cytokine release syndrome (CRS) is an adverse event with high incidence during CAR-T treatment. A further understanding of the characteristics and related risk factors CRS important effective management. total 142 patients acute lymphocyte leukemia (ALL), lymphoma, multiple myeloma (MM) received lymphodepletion...
The present study investigates the potential signal pathway of acacetin in cardioprotection against ischemia/reperfusion injury using an vitro hypoxia/reoxygenation model primary cultured neonatal rat cardiomyocytes and H9C2 cardiomyoblasts. It was found that (0.3-3 uM) significantly decreased apoptosis ROS production induced by cardiomyoblasts via reducing pro-apoptotic proteins Bax cleaved-caspase-3 increasing anti-apoptotic protein Bcl-2. In addition, not only suppressed release...
After diagnosis, glioblastoma (GBM) patients undertake tremendous psychological problems such as anxiety and depression, which may contribute to GBM progression. However, systematic study about the relationship between depression progression is still lacking.Chronic unpredictable mild stress chronic restrain were used mimic human in mice. Human cells intracranial model assess effects of on growth. Targeted neurotransmitter sequencing, RNA-seq, immunoblotting immunohistochemistry detect...
Abstract Transnitrosylation is an important mechanism by which nitric oxide (NO) modulates cell signaling pathways. For instance, SNO-caspase-3 can transnitrosylate the X-linked inhibitor of apoptosis (XIAP) to enhance apoptosis. XIAP a potent antagonist caspase apoptotic activity. Decrease in activity via nitrosylation results SNO-XIAP-mediated activation. Considering functional liaison procaspase-9 and XIAP, we hypothesized that nitrosylates directly. Our data confirmed cerebral...
Abstract Objectives We previously reported that Golgi phosphoprotein 3 (GOLPH3) promotes glioma progression by inhibiting EGFR endocytosis and degradation, leading to accumulation PI3K‐AKT pathway over‐activation. In the current study, we examine whether GOLPH3 affects response of cells gefitinib, an selective inhibitor. Materials Methods The expression in was detected immunofluorescence immunoblotting. cell viability or growth vitro determined CCK‐8, EdU incorporation clonogenic assays....
Abstract The overdiagnosis of subclinical hypothyroidism (SCH) in the elderly has driven researchers to establish age-specific thyroid stimulating hormone (TSH) intervals precisely evaluate prevalence SCH. Moreover, abnormal lipid profiles, an insidious manifestation SCH, show various impacts on different age groups. This study aimed TSH reference range clarify spectrum SCH elderly. dyslipidemia and association between profiles were analyzed elucidate relationship dyslipidemia....
Reactive oxygen species (ROS) and reactive nitrogen (RNS) are the production of renal ischemia/reperfusion (I/R). The current study is to elucidate a mechanism SIRT2 tyrosine nitration accelerate cell apoptosis induced by peroxynitrite (ONOO‾), most deleterious RNS type in (I/R) injury. Our results demonstrate that there significant enhancement 3-nitrotyrosine levels tissues Acute Kidney Injury (AKI) patients rats underwent I/R, positive correlation between level function impairment,...
Objective To investigate the diagnostic value of D-dimer, platelet-lymphocyte rate (PLR) and CT signs for intestinal ischemia in patients with bowel obstruction. Methods We retrospectively analyzed clinical imaging data 105 diagnosed obstruction, performed univariate multivariate analyses to determine independent risk factors Moreover, receiver operating characteristic curve (ROC) was plotted examine PLR Besides, Kappa tests were used assess inter-observer agreement. Results included 56 men...