A5037171489- MicroRNA in disease regulation
- Cardiac Ischemia and Reperfusion
- Angiogenesis and VEGF in Cancer
- Chemotherapy-induced cardiotoxicity and mitigation
- Ion channel regulation and function
- Cardiac electrophysiology and arrhythmias
- Cardiac Fibrosis and Remodeling
- Circular RNAs in diseases
- Sirtuins and Resveratrol in Medicine
- Cancer, Hypoxia, and Metabolism
- Cancer-related gene regulation
- Traditional Chinese Medicine Analysis
- Atherosclerosis and Cardiovascular Diseases
- Bioactive natural compounds
- RNA Research and Splicing
- Viral Infections and Immunology Research
- Extracellular vesicles in disease
- Ion Channels and Receptors
- Antioxidant Activity and Oxidative Stress
- Cell Adhesion Molecules Research
- Hippo pathway signaling and YAP/TAZ
- Infection Control and Ventilation
- Calcium signaling and nucleotide metabolism
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Liver Disease Diagnosis and Treatment
Xiamen University
2018-2024
First Affiliated Hospital of Xiamen University
2016-2024
South China Agricultural University
2022
Tân Tạo University
2021
Shaoguan Railway Hospital
2014
Zhongshan Hospital of Xiamen University
2013
The present study investigates the potential signal pathway of acacetin in cardioprotection against ischemia/reperfusion injury using an vitro hypoxia/reoxygenation model primary cultured neonatal rat cardiomyocytes and H9C2 cardiomyoblasts. It was found that (0.3-3 uM) significantly decreased apoptosis ROS production induced by cardiomyoblasts via reducing pro-apoptotic proteins Bax cleaved-caspase-3 increasing anti-apoptotic protein Bcl-2. In addition, not only suppressed release...
Cardiac senescence is associated with cardiomyopathy which a degenerative disease in the aging process of elderly. The present study investigates using multiple experimental approaches whether natural flavone acacetin could attenuate myocardial C57/BL6 mice and H9C2 rat cardiac cells induced by D-galactose. We found that impaired heart function D-galactose-induced accelerated was improved oral treatment dose-dependent manner. Acacetin significantly countered increased serum advanced...
Diabetic cardiomyopathy seriously affects the life quality of diabetic patients and can lead to heart failure death in severe cases. Acacetin was reported be an anti-oxidant anti-inflammatory agent several cardiovascular diseases. However, effect acacetin on not understood. This study designed explore therapeutic potential mechanism with vitro vivo experimental techniques. In cultured neonatal rat cardiomyocytes H9C2 cardiac cells, (0.3, 1, 3 μM) showed effective protection against high...
Acacetin is a natural source of flavonoids with anti-inflammatory and antioxidant effects.This study determines acacetin's protective effect mechanism on myocardial ischaemia/reperfusion (I/R) injury.Sprague-Dawley rats were divided into sham I/R injury treatment acacetin. (10 mg/kg) was subcutaneously injected for 7 days. ECG echocardiography conducted to determine arrhythmia heart function. The pathological characters the determined triphenyl tetrazolium chloride staining, Haematoxylin &...
Abstract Dysregulated angiogenesis leads to neovascularization, which can promote or exacerbate various diseases. Previous studies have proved that NEDD4L plays an important role in hypertension and atherosclerosis. Hence, we hypothesized may be a critical regulator of endothelial cell (EC) function. This study aimed define the regulating EC elucidate their underlying mechanisms. Loss‐ gain‐of‐function detected mobility human umbilical vein cells (HUVECs) using Matrigel tube formation assay,...
Abstract Oxidative stress has a considerable influence on endothelial cell dysfunction and atherosclerosis. Acacetin, an anti‐inflammatory antiarrhythmic, is frequently used in the treatment of myocarditis, albeit its role managing atherosclerosis currently unclear. Thus, we evaluated regulatory effects acacetin maintaining function further investigated whether flavonoid could attenuate apolipoprotein E deficiency (apoE −/− ) mice. Different concentrations were tested EA.hy926 cells, either...
Doxorubicin cardiotoxicity is frequently reported in patients undergoing chemotherapy. The present study investigates whether cardiomyopathy induced by doxorubicin can be improved the natural flavone acacetin a mouse model and uncovers potential molecular mechanism using cultured rat cardiomyoblasts. It was found that cardiac dysfunction myocardial fibrosis were significantly mice with impaired Nrf2/HO-1 Sirt1/pAMPK molecules, which reversed treatment. decreased cell viability increased ROS...
Abstract Myocardial infarction (MI) is one of the leading causes heart failure with highly complicated pathogeneses. miR-654-3p has been recognized as a pivotal regulator controlling cell survival. However, function in cardiomyocytes and MI yet to be reported. This study aimed identify role regulation myocardial infarction. To understand contribution on function, we generated cardiac-specific knockdown overexpression mice using AAV9 technology injury. Mechanically, combined cellular...
Abstract Background Angiogenesis is critical for forming new blood vessels from antedating vascular vessels. The endothelium essential angiogenesis, remodelling and minimisation of functional deficits following ischaemia. insulin‐like growth factor (IGF) family crucial angiogenesis. Insulin‐like factor‐binding protein 5 (IGFBP5), a binding the IGF family, may have places in but mechanisms are not yet completely understood. We sought to probe whether IGFBP5 involved pathological angiogenesis...
Aim: To explore circulating miRNA-302 family members for acute heart failure (AHF) diagnosis. Methods: Three groups of subjects, in other words, AHF patients, free patients and healthy controls were recruited. Circulating levels miR-302 measured analyzed Results: Plasma miR-302s except miR-302f significantly elevated patients. MiR-302b-3p had the highest area under curve value 0.87. There strong positive correlations between NT-proBNP levels. higher left ventricular ejection fraction ≤45%...
MiR-30a-5p plays an important role in various cardiovascular diseases, but its effect atherosclerosis has not been reported. Apolipoprotein E-deficient (Apo E-/-) mice were used to investigate the of miR-30a-5p atherosclerosis, and underlying mechanism was investigated vivo vitro. The fluorescence situ hybridization test revealed that expressed Apo E-/- lesions. Nevertheless, RAW264.7 macrophages, expression reduced by lipopolysaccharide (LPS) or oxidized low-density lipoprotein....
Concanavalin A (Con A) exhibited multiple roles in cancer cells. However, the role of Con endothelial cells was not reported.Our present study investigated potential angiogenic and ischaemic hind-limb mice.Human umbilical vein Ea.hy926 were employed to determine effect (0.3, 1, 3 μg/mL) or vehicle on angiogenesis cell proliferation with tube formation, ELISA, flow cytometry, EdU, western blot. Hind-limb mice conducted pro-angiogenic (10 mg/kg) for 7 days.Con promoted formation about...
Type II interleukin-1 receptor (IL-1RII) is a non-signaling decoy that blocks the activity of (IL-1), pro-inflammatory cytokine involved in experimental autoimmune myocarditis (EAM). The aim this study was to examine effects hydrodynamics-based delivery recombinant plasmid encoding IL-1RII-Ig and elucidate role IL-1RII EAM rats. Rats were immunized on day 0 injected with or pCAGGS-SP-Ig (control plasmid) 6. gene therapy effectively controlled as indicated by decreased heart weight-to-body...
Clemizole, a histamine H1 receptor antagonist has potential therapeutic effect on hepatitis C infection and also potently inhibits TRPC5 ion channels. The aim of the present study was to investigate whether clemizole blocks cardiac K+ currents thus affects repolarization.Whole-cell patch techniques used examine effects hERG channel current, IKs Kv 1.5 current in HEK 293 cell expression systems as well ventricular action potentials guinea pig hearts. Isolated hearts from pigs were determine...
Heart senescence is critical for cardiac function. This study aimed to characterize the role and mechanism of action miR-30a-5p in senescence. was downregulated aged mouse hearts neonatal rat cardiomyocytes (NRCMs). In vivo, using a combination echocardiography different molecular biological approaches, we investigated knockout or overexpression natural- D-galactose-induced heart aging mice. vitro, RNA sequencing series biology methods, by which regulates explored cardiomyocytes. mice showed...
Abstract Our recent study showed that bradykinin increases cell cycling progression and migration of human cardiac c‐Kit + progenitor cells by activating pAkt pERK1/2 signals. This investigated whether bradykinin‐mediated Ca 2+ signalling participates in regulating cellular functions cultured using laser scanning confocal microscopy biochemical approaches. It was found increased cytosolic free ( ) triggering a transient release from ER IP3Rs followed sustained influx through store‐operated...
Bacteria can withstand various types of environmental osmostress. A sudden rise in osmostress affects bacterial cell growth that is countered by activating special genes. The change generally a slow process under the natural environment. However, collective response bacteria to low remains unknown. This study revealed deletion phoP (ΔphoP) from X. citri significantly compromised and virulence as compared wild-type strain. Interestingly, reversed physiological deficiencies mutant related...