A5102758321- Software Engineering Research
- Software Reliability and Analysis Research
- Epigenetics and DNA Methylation
- Lipoproteins and Cardiovascular Health
- Lipid metabolism and biosynthesis
- Pancreatic function and diabetes
- MicroRNA in disease regulation
- Extracellular vesicles in disease
- Cell Adhesion Molecules Research
- Antioxidant Activity and Oxidative Stress
- Atherosclerosis and Cardiovascular Diseases
- Circadian rhythm and melatonin
- Cardiac Fibrosis and Remodeling
- Neonatal Respiratory Health Research
- Software Testing and Debugging Techniques
- Inflammation biomarkers and pathways
- Literature, Magical Realism, García Márquez
- Adsorption, diffusion, and thermodynamic properties of materials
- Synthesis of heterocyclic compounds
- RNA Interference and Gene Delivery
- Antimicrobial Peptides and Activities
- Click Chemistry and Applications
- Neurological Disease Mechanisms and Treatments
- Imbalanced Data Classification Techniques
- HER2/EGFR in Cancer Research
Sun Yat-sen University
2019-2025
Hospital of Stomatology, Sun Yat-sen University
2019-2025
First Affiliated Hospital of Xiamen University
2018-2023
University of Hong Kong
2022
Xiamen University
2020-2022
Stomatology Hospital
2019-2020
University of Calgary
2006-2008
National Institutes of Pharmaceutical Research and Development (China)
1998
A highly efficient and versatile method for the synthesis of benzimidazoles was achieved in one step via Na2S2O4 reduction o-nitroanilines presence aldehydes. Heating a solution o-nitroaniline (1c) an aldehyde EtOH or another appropriate solvent, aqueous solid Na2S2O4, provided facile access to series 2-substituted N-H 5a-m containing wide range functional groups not always compatible with existing synthetic methods. This methodology has also been applied regioselective N-alkyl N-aryl 6a-f...
Abstract Oxidative stress has a considerable influence on endothelial cell dysfunction and atherosclerosis. Acacetin, an anti‐inflammatory antiarrhythmic, is frequently used in the treatment of myocarditis, albeit its role managing atherosclerosis currently unclear. Thus, we evaluated regulatory effects acacetin maintaining function further investigated whether flavonoid could attenuate apolipoprotein E deficiency (apoE −/− ) mice. Different concentrations were tested EA.hy926 cells, either...
This study explored the role of Piezo1 in odontogenic differentiation dental papilla cells (DPCs) and tissue, focusing on a mechanism involving family with sequence similarity 83, member G (FAM83G). Here, we found Piezo1, mechanosensitive cation channel, was upregulated during odontogenesis DPCs tissues. Knockdown impaired differentiation, while its activation by Yoda1 enhanced process. Using 3D culture model an ectopic transplantation model, confirmed Piezo1’s vivo. RNA sequencing (RNA-seq)...
Advances in the design of permeable peptides and synthesis large arrays macrocyclic with diverse amino acids have evolved on parallel but independent tracks. Less precedent combines their respective attributes, thereby limiting potential to identify peptide ligands for key targets. Herein, we present novel 6-, 7-, 8-mer cyclic (MW 774–1076 g·mol–1) passive permeability oral exposure that feature thioether ring-closing common array formats, including DNA- RNA-templated synthesis. Each herein,...
Differentiation potency of human dental pulp cells (hDPCs) is essential for dentin regeneration. DNA methylation one the major epigenetic mechanisms and suggested to involve in differentiation hDPCs, machinery which includes methyltransferase enzymes (DNMTs) methyl-CpG-binding domain proteins (MBDs). Our previous study has found that melatonin (MT) promoted hDPC differentiation, but its mechanism remains elusive. We aimed investigate role promotion MT hDPCs vitro. were cultured basal growth...
Five heuristics for attribute weighting in analogy-based effort estimation are evaluated this paper. The baseline heuristic involves using all attributes with equal weights. We propose four additional that use rough set analysis weighting. These five over data sets related to software projects. Three of the publicly available, hence allowing comparison other methods. results indicate three based perform better than weights heuristic. This evaluation is on an integrated measure accuracy.
Modification of a gut restricted class benzimidazole DGAT1 inhibitor 1 led to 9 with good oral bioavailability. The key structural changes include bioisosteric replacement the amide oxadiazole and α,α-dimethylation carboxylic acid, improving potency permeability. Since is expressed in small intestine, both can suppress postprandial triglycerides during acute lipid challenges rats dogs. Interestingly, only was found be effective suppressing body weight gain relative control diet-induced obese...
Estimation by analogy (EBA) predicts effort for a new project learning from the performance of former projects. This is done aggregating information similar projects given historical data set that contains projects, or objects in general, and attributes describing objects. While this has been successful existing research results have shown carefully selected subset, as well weighting, may improve estimation methods. In order to accuracy our proposed EBA method AQUA, which supports sets...
Melatonin, at physiological concentrations, was previously found to inhibit proliferation and promote odontogenic differentiation in human dental pulp cells (hDPCs), but its effect on apoptosis is unclear. Our study aimed investigate the of melatonin H2O2-mediated viability reduction hDPCs. hDPCs were treated with H2O2 (0, 250, 500, 1000 μmol/L), 10−12, 10−10, 10−8 mol/L), for 24 h. CCK-8 assays performed evaluate cell viability. Apoptosis measured by DAPI Annexin V/propidium iodide...
N-Acetyl-5-methoxytryptamine (melatonin, MT) at pharmacological concentrations promotes the osteogenic differentiation of human bone marrow-derived mesenchymal stem cells; however, its role physiological (1 pM–10 nM) remains unclear. We explored effects 1 pM–1 µM MT on periodontal ligament cells (hPDLSCs) and underlying mitochondrial dynamics-mediated mechanisms. T he PDLSC phenotype was detected by flow cytometry evaluated for three-line differentiation. Alkaline phosphatase activity assay...
The quality of results from a predictor model depends on the proper customization parameters model. For Estimation by Analogy (EBA), impact parameter "Attribute weighting technique" has been shown several authors. decision problem "Which attribute technique is preferable for EBA in which situation?" considered this paper perspective multi-criteria analysis (MCDA). empirical are given method AQUA+.
In a certain period, some news will compete for the top to gain most attention and influence, more be submerged in ocean of become mediocre. This article deeply studies evolution process competition mechanism dissemination Weibo news. this paper, we innovatively propose pre-processing scheme traditional small–world networks scale–free divide nodes into three roles: fans, passersby, anti-fans. The is defined from aspects node role aggregation degree. A network model established based on...
Mutations in the triggering receptor expressed myeloid 2 (TREM2) gene have recently been found to be closely related development of Alzheimer's disease (AD) and other neurodegenerative diseases. However, detailed mechanism underlying TREM2’s participation pathogenesis AD diseases has yet fully elucidated. In this review, we discuss current understanding on structure function TREM2, relevance between TREM2 AD, possible causes by mutations. Key words: Alzheimer's disease; Triggering 2; DAP12
Abstract Background : Oxidative stress has a considerable influence on endothelial cell dysfunction and atherosclerosis. Acacetin, an anti-inflammatory antiarrhythmic, is frequently used in the treatment of myocarditis, albeit its role managing atherosclerosis currently unclear. Thus, we evaluated regulatory effects acacetin maintaining function further investigated whether flavonoid could attenuate apolipoprotein E deficiency (apoE -/- ) mice. Methods Different concentrations were tested...
Abstract Aims: Protection of cardiac function following myocardial infarction was largely enhanced by bradykinin-pretreated cardiac-specific c-kit + (BK-c-kit ) cells, even without significant engraftment, indicating that paracrine actions BK-c-kit cells play a pivotal role in angiogenesis. Nevertheless, the active components and underlying mechanisms remain unknown. This study aimed to define exosomes from elucidate their protective mechanisms. Methods results: Matrigel tube formation...
Elevated LDL-C is a major risk factor for atherosclerotic cardiovascular disease, the leading cause of death worldwide. Proprotein convertase subtilisin/kexin type 9 (PCSK9) has pronounced effects on levels via its modulation hepatic LDL receptors (LDLR), main pathway cholesterol removal from circulation. The epidermal growth precursor homology domain A (EGF-A) LDLR serves as primary contact with PCSK9 flat interface, presenting challenge identifying small molecule PCSK9-LDLR disruptors. We...