A5047609104- Circadian rhythm and melatonin
- Pain Mechanisms and Treatments
- Neuropeptides and Animal Physiology
- Neuroscience of respiration and sleep
- Spaceflight effects on biology
- Nitric Oxide and Endothelin Effects
- Mesenchymal stem cell research
- Cancer, Hypoxia, and Metabolism
- Sleep and Wakefulness Research
- Biochemical effects in animals
- Stress Responses and Cortisol
- Heme Oxygenase-1 and Carbon Monoxide
- Liver physiology and pathology
- Dietary Effects on Health
- Trigeminal Neuralgia and Treatments
- Digestive system and related health
- Traditional Chinese Medicine Analysis
- Neuroinflammation and Neurodegeneration Mechanisms
- Epigenetics and DNA Methylation
- Ion channel regulation and function
- Nerve injury and regeneration
- Neuroscience and Neuropharmacology Research
- RNA modifications and cancer
- Connexins and lens biology
- Cannabis and Cannabinoid Research
Sun Yat-sen University
2014-2025
Hospital of Stomatology, Sun Yat-sen University
2012-2025
Dongguan People’s Hospital
2025
Stomatology Hospital
2012-2022
The Third Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine
2005
Third Affiliated Hospital of Sun Yat-sen University
2004
College of Medical Sciences
2003
Alzheimer disease (AD) is an age-related neurodegenerative disorder characterized by the presence of senile plaques, neurofibrillary tangles and neuronal loss. Amyloid-β protein (Aβ) deposition plays a critical role in development AD. It now generally accepted that massive death due to apoptosis common characteristic brains patients suffering from diseases, apoptotic cell has been found neurons glial cells Melatonin secretory product pineal gland; melatonin potent antioxidant free radical...
Background:Aging is a highly complex process that affects various tissues and systems in the body. Senescent changes are relatively more prevalent severe postmitotic cells. Mitochondria play an important role aging process. Recently, cell cultures have been widely used as vitro model to study aging. The present was designed investigate mitochondrial dysfunction associated with long-term culture system.Material/Methods:Rat hippocampal neurons were maintained serum-free medium for 30 days...
Melatonin mediates a variety of biological processes ranging from the control circadian rhythms to immune regulation. also influences bone formation and osteointegration dental implants. However, effects melatonin on dentine have not been examined. This study investigated proliferation differentiation rat papilla cells (rDPCs) in vitro vivo. We found that (0, 10(-12) , 10(-10) ,10(-8) m) induced dose-dependent reduction rDPCs proliferation, increased alkaline phosphatase (ALP) activity,...
Orofacial inflammation leads to transcriptional alterations in trigeminal ganglion (TG) neurons. However, diverse and regulatory mechanisms following orofacial inflammatory pain different types of TG neurons remain unclear. Here, was induced by injection complete Freund’s adjuvant (CFA) mice. After 7 days, we performed single-cell RNA-sequencing on cells mice from control treatment groups. We identified primary sensory neurons, Schwann cells, satellite glial oligodendrocyte-like immune...
This study explored the role of Piezo1 in odontogenic differentiation dental papilla cells (DPCs) and tissue, focusing on a mechanism involving family with sequence similarity 83, member G (FAM83G). Here, we found Piezo1, mechanosensitive cation channel, was upregulated during odontogenesis DPCs tissues. Knockdown impaired differentiation, while its activation by Yoda1 enhanced process. Using 3D culture model an ectopic transplantation model, confirmed Piezo1’s vivo. RNA sequencing (RNA-seq)...
Apical periodontitis (AP) causes arrest of tooth root development, which is associated with impaired odontoblastic differentiation stem cells from apical papilla (SCAPs), but the underlying mechanism remains unclear. Here, we investigated roles extracellular vesicle (EV) in AP and SCAPs, moreover, a novel nuclear factor I/C (NFIC)-encapsulated EV was developed to promote dentin regeneration. We detected higher expression marker CD63 inflamed papilla, found that EVs LPS-stimulated dental pulp...
Odontoblastic differentiation of human stem cells from the apical papilla (hSCAPs) is crucial for continued root development and dentin formation in immature teeth with periodontitis (AP). Fat mass obesity-associated protein (FTO) has been reported to regulate bone regeneration osteogenic profoundly. However, effect FTO on hSCAPs remains unknown. This study aimed identify potential function hSCAPs’ odontoblastic under normal inflammatory conditions investigate its underlying mechanism...
beta-Amyloid (Abeta) is strongly involved in the pathogenesis of Alzheimer's disease (AD), and mitochondria play an important role neurodegenerative disorders. To determine whether any different effect melatonin on cultured neurons treated with Abeta vitro which may be produced through its action at stages culture, we investigated damage rat hippocampal mitochondrial function induced by young [days 10 (DIV 10)] senescent 25) protective melatonin. Rat were incubated amyloid-beta peptide 25-35...
Differentiation potency of human dental pulp cells (hDPCs) is essential for dentin regeneration. DNA methylation one the major epigenetic mechanisms and suggested to involve in differentiation hDPCs, machinery which includes methyltransferase enzymes (DNMTs) methyl-CpG-binding domain proteins (MBDs). Our previous study has found that melatonin (MT) promoted hDPC differentiation, but its mechanism remains elusive. We aimed investigate role promotion MT hDPCs vitro. were cultured basal growth...
Tooth development is a complex process that tightly controlled by circadian rhythm. Melatonin (MT) major hormonal regulator of the rhythm, and influences dentin formation odontoblastic differentiation during tooth development; however, underlying mechanism remains elusive. This study investigated how MT regulates differentiation, with special focus on its regulation mitochondrial dynamics. In rat dental papilla cells (DPCs), we found promotes concurrently enhanced fusion, while disruption...