A5101679559- Reproductive Biology and Fertility
- Mesenchymal stem cell research
- Circadian rhythm and melatonin
- Sperm and Testicular Function
- Immune cells in cancer
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Allelopathy and phytotoxic interactions
- Renal and related cancers
- Fungal Biology and Applications
- Advanced Glycation End Products research
- Neuroinflammation and Neurodegeneration Mechanisms
- Spaceflight effects on biology
- Virus-based gene therapy research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Ovarian function and disorders
- Tryptophan and brain disorders
- Growth Hormone and Insulin-like Growth Factors
- Biochemical effects in animals
- Autophagy in Disease and Therapy
- Estrogen and related hormone effects
- Sirtuins and Resveratrol in Medicine
- dental development and anomalies
- Plant Pathogens and Fungal Diseases
- Ginkgo biloba and Cashew Applications
- Glioma Diagnosis and Treatment
Xinxiang Medical University
2024
Henan Psychiatric Hospital
2024
Sun Yat-sen University
2017-2024
Hospital of Stomatology, Sun Yat-sen University
2020-2024
Institute of Microbiology
2022
Chinese Academy of Sciences
2022
Sichuan University
2013-2020
West China Hospital of Sichuan University
2020
Stomatology Hospital
2020
West China Second University Hospital of Sichuan University
2013
Abstract Diabetic nephropathy (DN) as a kind of serious microvascular complication Diabetes Mellitus (DM) usually causes the end‐stage renal disease (ESRD). Studies have demonstrated that CD103 + dendritic cells (DCs) exhibited pathogenic effect in murine chronic kidney (CKD). Mesenchymal stem (MSCs) can alleviate DN and suppress DCs maturation. To explore role potential mechanisms underlying MSCs‐mediated protective effects DN, we used bone marrow MSCs (BM‐MSCs) to treat rats....
Defining the gonadal effects of FSH distinct from those LH remains difficult. We have characterized and compared level Sertoli germ cell development in three mouse models recently created to isolate activity effects. Two used LH-deficient hypogonadal (hpg) mice selectively study either pituitary-independent transgenic (tg) or ligand-independent activated tg receptor (FSHR+) expression, third model (LHR)-deficient examine endogenous Stereological evaluation revealed tg-FSH tg-FSHR+...
Abstract Acute kidney injury (AKI) is a clinical condition that associated with high morbidity and mortality. Inflammation reported to play key role in AKI. Although the M2 macrophages exhibit antimicrobial anti‐inflammatory activities, their therapeutic potential has not been evaluated for This study aimed investigate protective effect of peritoneal macrophage transplantation on AKI mice. The were isolated from dialysates induced undergo polarization using interleukin (IL)‐4/IL‐13. was mice...
Diabetes affects a variety of organs such as the kidneys, eyes, and liver, there is increasing evidence that lung also one target diabetes imbalance Sirt3-mediated stress responses inflammation, oxidative stress, apoptosis, autophagy, ER may contribute to diabetic fibrosis. Although previous studies have reported mesenchymal stem cells (MSCs) beneficial effects on various complications, effect mechanisms MSCs diabetes-induced injury are not clear. In this study, STZ-induced model was...
Odontoblastic differentiation of human stem cells from the apical papilla (hSCAPs) is crucial for continued root development and dentin formation in immature teeth with periodontitis (AP). Fat mass obesity-associated protein (FTO) has been reported to regulate bone regeneration osteogenic profoundly. However, effect FTO on hSCAPs remains unknown. This study aimed identify potential function hSCAPs’ odontoblastic under normal inflammatory conditions investigate its underlying mechanism...
Female mice lacking AR display alterations in ovarian and uterine function. However, the biology of fallopian tube is not fully understood. To gain an insight into potential roles this tissue, we demonstrated that eCG treatment increased expression a time-dependent manner subsequent with hCG decreased mouse tubes. This pattern was positively associated 17beta-estradiol testosterone levels vivo. Immunohistochemical analysis epithelial cells revealed nuclear localization parallel cytoplasm...
This research is aimed at investigating how high glucose affects the proliferation and apoptosis in periodontal ligament stem cells (PDLSCs) presence of TNF-α. PDLSCs obtained from healthy permanent teeth were treated under either high-glucose condition (30 mmol/L, G30 group) or normal (5.6 G5.6 absence α. CCK-8 assay showed that exacerbated High exacerbates TNF-α-induced proliferative inhibition human through upregulation activation TNF receptor 1. Inhibition intracellular ROS expression by...
Brown-Borg HM, Zhang F-P, Huhtaniemi I, Bartke A. Developmental aspects of prolactin receptor gene expression in fetal and neonatal mice. Eur J Endocrinol 1996;134:751–7. ISSN 0804–4643 The (PRL-R), a member the hematopoietin cytokine superfamily, is widely distributed among mammalian tissues. To understand better potential sites action onset PRL responsiveness, developmental distribution pattern PRL-R mRNA mice was examined. Fetal mouse tissues were collected at distinct stages from timed...
SIRT4 is a mitochondrial sirtuin. Owing to its dependance on the cofactor nicotinamide adenine dinucleotide (NAD+), can act as metabolic sensor of cellular energy status. We have previously shown that enhancement functions vital for odontogenic diff ;erentiation dental papilla cells (DPCs) during dentinogenesis. However, whether serves an effective regulator DPC by affecting remains unexplored. Primary DPCs obtained from first molar neonatal Sprague-Dawley rats were used in this study. The...
Androgen receptor-interacting protein 4 (ARIP4) belongs to the SNF2 family of proteins involved in chromatin remodeling, DNA excision repair, and homologous recombination. It is a DNA-dependent ATPase, binds mononucleosomes, interacts with androgen receptor (AR) modulates AR-dependent transactivation. We have examined this study expression cellular localization ARIP4 during postnatal development mouse testis. was detected by immunohistochemistry Sertoli cell nuclei at all ages studied,...
Measurement of inhibins A and B in the serum normal cyclic rodents has implicated FSH regulation these peptides within ovary. To extend observations we have used a panel mutant mice carrying mutations which affect either production of, or ability to respond to, LH. As consequence, females are infertile show different degrees follicular development. The aim this study was measure inhibin gene transcription ovaries together with protein levels relate development Comparison made pool...
Abstract The aim of this study was to explore the effects platelet‐rich plasma on gingipain‐caused changes in cell morphology and apoptosis osteoblasts. Mouse osteoblasts MC3T3‐E1 cells were treated with gingipain extracts from Porphyromonas gingivalis presence or absence plasma. Apoptosis detected terminal deoxynucleotidyl transferase‐mediated dUTP nick‐end labeling staining. F‐actin determined by phalloidin‐fluorescent staining observed under confocal microscopy. Western blot analysis used...
Zika virus (ZIKV)-specific T cells are activated by different peptides derived from structural and nonstructural proteins, contributed to the viral clearance or protective immunity. Herein, we have depicted profile of CD8+ CD4+ cell immunogenicity ZIKV proteins in C57BL/6 (H-2b) BALB/c (H-2d) mice, found that featured cellular immunity antigens were variant among murine alleles. In H-2b E, NS2, NS3 NS5 recognized as immunodominant cells, while NS4 is dominantly cells. contrast, H-2d NS1...
Sperm differentiation requires specific protein transport for correct sperm tail formation and head shaping. A transient microtubular structure, the manchette, appears around differentiating spermatid serves as a platform to growing tail. flagellar 2 (SPEF2) is known be essential development. In this study we investigated function of SPEF2 during spermatogenesis using male germ cell-specific Spef2 knockout mouse model. addition defects in development, observed duplication basal body failure...
Post-stroke depression (PSD) is one of the most common mental sequelae after a stroke and can damage brain. In recent years, PSD has been studied more more, but its exact mechanism remains unclear. Current animal models provide an alternative approach to better understand pathophysiological mechanisms PSD. DAPK1 reported be abnormally elevated in various neurodegenerative diseases, such as depression, ischemic stroke, Alzheimer's disease. Therefore, this study investigated possible molecular...
In this study, a new type of dithiocarbamate (DTCs) heavy metal chelating agent MF-DTC was prepared by carbon disulfide modified melamine formaldehyde resin prepolymer, and the structure products characterized infrared, ultraviolet, elemental analysis, thermogravimetry, scanning electron microscopy other means: process Cu studied, results showed that had higher adsorption capacity, compared with traditional SDD Na2S, it capacity under acidic conditions, can be directly used to treat metals...
The circadian clock is involved in many physiological processes including teeth development. expression of core genes was observed various tissues, but their role odontoblasts unclear. aim this study to investigate the gene expressions dental papilla cells (DPCs) during odontogenic differentiation. Primary DPCs were obtained from first molar neonatal rats and cultured osteogenic (OS) medium for differentiation vitro. Reverse transcription quantitative PCR performed assess mRNA levels Bmal1,...