Jukka Kero
A5016106030- Thyroid Disorders and Treatments
- Diabetes and associated disorders
- Pancreatic function and diabetes
- Diabetes Management and Research
- Growth Hormone and Insulin-like Growth Factors
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Thyroid Cancer Diagnosis and Treatment
- Hypothalamic control of reproductive hormones
- Receptor Mechanisms and Signaling
- Reproductive Biology and Fertility
- Sperm and Testicular Function
- Neonatal Health and Biochemistry
- Estrogen and related hormone effects
- Erythrocyte Function and Pathophysiology
- Congenital heart defects research
- Dermatology and Skin Diseases
- Neuroscience of respiration and sleep
- Cancer-related Molecular Pathways
- Neonatal Respiratory Health Research
- Asthma and respiratory diseases
- Genetic and Kidney Cyst Diseases
- Adipose Tissue and Metabolism
- MicroRNA in disease regulation
- RNA modifications and cancer
- Ovarian function and disorders
Turku University Hospital
2013-2025
University of Turku
2016-2025
Metropolitan University
2022
Heidelberg University
2003-2014
Glasgow Royal Infirmary
2000
University of Córdoba
1999
As a treatment for dyslipidemia, oral doses of 1–3 grams nicotinic acid per day lower serum triglycerides, raise high density lipoprotein cholesterol, and reduce mortality from coronary heart disease (Tavintharan, S., Kashyap, M. L. (2001) Curr. Atheroscler. Rep. 3, 74–82). These benefits likely result the ability to inhibit lipolysis in adipocytes thereby non-esterified fatty levels (Carlson, A. (1963) Acta Med. Scand. 173, 719–722). In mice, inhibits via PUMA-G, Gi/o-coupled...
Nicotinic acid (niacin) is a drug used to reduce the progression of atherosclerosis. Its antiatherosclerotic activity believed result from lipid-modifying effects, including its ability decrease LDL cholesterol and increase HDL levels in plasma. Here, we report that mouse model atherosclerosis, found nicotinic inhibited disease under conditions left total plasma unaffected. The effect was not seen mice lacking receptor for GPR109A. Surprisingly, transplantation bone marrow GPR109A-deficient...
Nicotinic acid (niacin) has long been used as an antidyslipidemic drug. Its special profile of actions, especially the rise in HDL-cholesterol levels induced by nicotinic acid, is unique among currently available pharmacological tools to treat lipid disorders. Recently, a G-protein–coupled receptor, termed GPR109A (HM74A humans, PUMA-G mice), was described and shown mediate acid–induced antilipolytic effects adipocytes. One major problems pharmacotherapeutical use strong flushing response....
MicroRNAs (miRNAs) are negative modulators of gene expression that fine-tune numerous biological processes. miRNA loss-of-function rarely results in highly penetrant phenotypes, but rather, influences cellular responses to physiologic and pathophysiologic stresses. Here, we have reported a single member the evolutionarily conserved miR-7 family, miR-7a2, is essential for normal pituitary development hypothalamic-pituitary-gonadal (HPG) function adulthood. Genetic deletion mir-7a2 causes...
OBJECTIVE To distinguish among predictors of seroconversion, progression to multiple autoantibodies and from type 1 diabetes in young children. RESEARCH DESIGN AND METHODS Genetically high-risk newborns (n = 8,502) were followed for a median 11.2 years (interquartile range 9.3–12.6); 835 (9.8%) developed islet 283 (3.3%) diagnosed with diabetes. Predictors examined using Cox proportional hazards models. RESULTS seroconversion differed, depending on the first appearing autoantibody. Male sex,...
Transgenic (TG) female mice expressing bLHbeta-CTP (a chimeric protein derived from the beta-subunit of bovine luteinizing hormone [LH] and a fragment human chorionic gonadotropin [hCG]) exhibit elevated serum LH, infertility, polycystic ovaries, ovarian tumors. In humans, increased LH secretion also occurs in infertility syndrome, often concomitant with adrenocortical dysfunction. We therefore investigated adrenal function overexpressing mice. The size their adrenals was by 80% histological...
The G-protein-coupled receptor GPR109A (HM74A/PUMA-G) has recently been shown to function as a for nicotinic acid (niacin) and mediate its antilipolytic effects. Nicotinic is able strongly raise plasma levels of high-density lipoprotein cholesterol, property that distinguishes from other lipid-lowering drugs. To investigate the structural determinants ligand binding, we performed site-directed mutagenesis putative binding residues combined with generation chimeric receptors consisting close...
The function of the adult thyroid is regulated by thyroid-stimulating hormone (TSH), which acts through a G protein-coupled receptor. Overactivation TSH receptor results in hyperthyroidism and goiter. Gs-mediated stimulation adenylyl cyclase-dependent cAMP formation has been regarded as principal intracellular signaling mechanism mediating action TSH. Here we show that Gq/G11-mediated pathway plays an unexpected essential role regulation function. Mice lacking alpha subunits Gq G11...
The steroid hormone progesterone exerts pleiotrophic functions in many cell types. Although controls transcriptional activation through binding to its nuclear receptors, it also initiates rapid nongenomic signaling events. Recently, three putative membrane progestin receptors (mPRalpha, beta, and gamma) with structural similarity G protein-coupled have been identified. These mPR isoforms are expressed a tissue-specific manner belong the larger, highly conserved family of adiponectin found...
Congenital hypothyroidism (CH) is defined as the lack of thyroid hormones at birth. Mutations in least 15 different genes have been associated with this disease. While up to 20% CH cases are hereditary, majority sporadic unknown etiology. Apart from a monogenic pattern inheritance, multigenic mechanisms suggested play role CH. The genetics has not studied Finland so far. Therefore, sequencing candidate was performed Finnish patient cohort both familial and CH.A targeted next-generation (NGS)...
The first-appearing β-cell autoantibody has been shown to influence risk of type 1 diabetes (T1D). Here, we assessed the spreading second-appearing and further progression clinical disease in Environmental Determinants Diabetes Young (TEDDY) study.
Defects in genes mediating thyroid hormone biosynthesis result dyshormonogenic congenital hypothyroidism (CH). Here, we report homozygous truncating mutations SLC26A7 6 unrelated families with goitrous CH and show that also occurs Slc26a7-null mice. In both species, the gene is expressed predominantly gland, loss of function associated impaired availability iodine for synthesis, partially corrected mice by supplementation. a member same transporter family as SLC26A4 (pendrin), an anion...
OBJECTIVE Islet autoimmunity develops before clinical type 1 diabetes and includes multiple single autoantibody phenotypes. The objective was to determine age-related risks of islet autoantibodies that reflect etiology improve screening for presymptomatic diabetes. RESEARCH DESIGN AND METHODS Environmental Determinants Diabetes in the Young study prospectively monitored 8,556 genetically at-risk children at 3- 6-month intervals from birth development change risk developing determined using...
Recently, we demonstrated that triiodothyronine (T(3)) stimulated steroid hormone biosynthesis and steroidogenic acute regulatory (StAR) protein expression in mLTC-1 mouse Leydig tumor cells through the mediation of factor 1 (SF-1). We now report a dual response mechanism T(3) on steroidogenesis StAR expression, LH receptor (LHR) binding cells. acutely (8 h), induced 260% increase messenger RNA (mRNA) over basal level which was coincident with an progesterone (P) production. In contrast,...
Children at increased genetic risk for type 1 diabetes (T1D) after environmental exposures may develop pancreatic islet autoantibodies (IA) a very young age. Metabolic profile changes over time imply responses to and signal development of the first IA. Our present research in The Environmental Determinants Diabetes Young (TEDDY) study aimed identify metabolome-wide signals preceding IA against GAD (GADA-first) or insulin (IAA-first). We profiled metabolomes by mass spectrometry from...
OBJECTIVE This study investigates two-phase growth patterns in early life and their association with development of islet autoimmunity (IA) type 1 diabetes (T1D). RESEARCH DESIGN AND METHODS The Environmental Determinants Diabetes the Young (TEDDY) followed 7,522 genetically high-risk children Sweden, Finland, Germany, U.S. from birth for a median 9.0 years (interquartile range 5.7–10.6) available data. Of these, 761 (10.1%) developed IA 290 (3.9%) were diagnosed T1D. Bayesian piecewise...
Abstract The primary cilium is well-preserved in human differentiated thyroid cancers such as papillary and follicular carcinoma. Specific Hürthle cell carcinoma, oncocytic variant of carcinoma (PTC), PTC with Hashimoto’s thyroiditis show reduced biogenesis cilia; these are often associated the abnormalities mitochondrial function. Here, we examined association between cilia mitochondria-dependent apoptosis pathway. Tg-Cre;Ift88 flox/flox mice (in which follicles lacked cilia) showed...
This study investigated physical activity and its association with the development of islet autoimmunity type 1 diabetes in genetically at-risk children aged 5-15 years.