A5102759090- Biological and pharmacological studies of plants
- Cardiac Ischemia and Reperfusion
- Bioactive natural compounds
- Synthesis and Biological Evaluation
- Antibiotic Use and Resistance
- Immune Response and Inflammation
- Analytical Methods in Pharmaceuticals
- Redox biology and oxidative stress
- Traditional Chinese Medicine Analysis
- Herpesvirus Infections and Treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Toxoplasma gondii Research Studies
- Pesticide Exposure and Toxicity
- Paraquat toxicity studies and treatments
- Cytomegalovirus and herpesvirus research
- Antibiotics Pharmacokinetics and Efficacy
- Thermal Regulation in Medicine
- Cell death mechanisms and regulation
Xuzhou Medical College
2012-2024
Affiliated Hospital of Xuzhou Medical College
2012-2013
Abstract Transnitrosylation is an important mechanism by which nitric oxide (NO) modulates cell signaling pathways. For instance, SNO-caspase-3 can transnitrosylate the X-linked inhibitor of apoptosis (XIAP) to enhance apoptosis. XIAP a potent antagonist caspase apoptotic activity. Decrease in activity via nitrosylation results SNO-XIAP-mediated activation. Considering functional liaison procaspase-9 and XIAP, we hypothesized that nitrosylates directly. Our data confirmed cerebral...
Sepsis-induced acute lung injury (ALI) is a severe complication of sepsis. Karanjin, natural flavonoid compound, has been proved to have anti-inflammatory function, but its role in sepsis-stimulated ALI uncertain. Herein, the effect karanjin on was investigated. We built mouse model lipopolysaccharide (LPS)-stimulated ALI. The histopathological morphology tissues scrutinized by hematoxylin-eosin (H&E) staining. score and wet/dry weight ratio were detected. myeloperoxidase (MPO) activity...
Abstract Human cytomegalovirus (HCMV) infection in the respiratory tract leads to pneumonitis immunocompromised hosts without available vaccine. Considering (CMV) mainly invades through tract, CMV‐specific pulmonary mucosal vaccine development that provides a long‐lasting protection against CMV challenge gains our attention. In this study, N‐terminal domain of GP96 (GP96‐NT) was used as adjuvant enhance induction pulmonary‐resident CD8 T cells elicited by MCMV glycoprotein B (gB) Mice were...
This study focused on the application value of CT images patients with organophosphorus poisoning lung injury. Specifically, 50 diagnosed pesticide injury in hospital were selected as research subjects. They all had chest examinations. Patients classified according to different degrees poisoning, and groups compared for levels C-reactive protein (CRP) procalcitonin (PCT) serum. The results showed that, patients, 25 mild accounting 50%, 14 moderate 28%, 11 suffered from severe poisoning. It...
Objective To investigate the effect of penehyclidine hydrochloride(PHC) on pulmonary interstitial fibrosis(PIF) induced by paraquat (PQ) in rats.Methods Forty-eight male SD rats were randomly divided into four groups,control group(Con group),model group(Mod group),PHC group and dexamethasone(Dex) group.Then every was 7th day 22th subgroup,there 6 group.20％ PQ (18 mg/kg,diluted to 1 ml) injected peritoneally make poisoning model,while Con ml normal saline used.30 min after exposed PQ,rats PHC...